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Nonlinear contrast enhancement in photoacoustic molecular imaging with gold nanosphere encapsulated nanoemulsions

A composite contrast agent, a nanoemulsion bead with assembled gold nanospheres at the interface, is proposed to improve the specific contrast of photoacoustic molecular imaging. A phase transition in the bead's core is induced by absorption of a nanosecond laser pulse with a fairly low laser fluenc... Full description

Journal Title: Applied Physics Letters 20 January 2014, Vol.104(3)
Main Author: Wei, Chen-Wei
Other Authors: Lombardo, Michael , Larson-Smith, Kjersta , Pelivanov, Ivan , Perez, Camilo , Xia, Jinjun , Matula, Thomas , Pozzo, Danilo , O'Donnell, Matthew
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © 2014 AIP Publishing LLC (AIP)
ID: ISSN: 0003-6951 ; E-ISSN: 1077-3118 ; DOI: 10.1063/1.4862461
Link: http://dx.doi.org/10.1063/1.4862461
Zum Text:
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recordid: aip_complete10.1063/1.4862461
title: Nonlinear contrast enhancement in photoacoustic molecular imaging with gold nanosphere encapsulated nanoemulsions
format: Article
creator:
  • Wei, Chen-Wei
  • Lombardo, Michael
  • Larson-Smith, Kjersta
  • Pelivanov, Ivan
  • Perez, Camilo
  • Xia, Jinjun
  • Matula, Thomas
  • Pozzo, Danilo
  • O'Donnell, Matthew
subjects:
  • Biophysics And Bio-Inspired Systems
ispartof: Applied Physics Letters, 20 January 2014, Vol.104(3)
description: A composite contrast agent, a nanoemulsion bead with assembled gold nanospheres at the interface, is proposed to improve the specific contrast of photoacoustic molecular imaging. A phase transition in the bead's core is induced by absorption of a nanosecond laser pulse with a fairly low laser fluence (∼3.5 mJ/cm 2 ), creating a transient microbubble through dramatically enhanced thermal expansion. This generates nonlinear photoacoustic signals with more than 10 times larger amplitude compared to that of a linear agent with the same optical absorption. By applying a differential scheme similar to ultrasound pulse inversion, more than 40 dB contrast enhancement is demonstrated with suppression of background signals.
language: eng
source: © 2014 AIP Publishing LLC (AIP)
identifier: ISSN: 0003-6951 ; E-ISSN: 1077-3118 ; DOI: 10.1063/1.4862461
fulltext: fulltext
issn:
  • 0003-6951
  • 1077-3118
  • 00036951
  • 10773118
url: Link


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titleNonlinear contrast enhancement in photoacoustic molecular imaging with gold nanosphere encapsulated nanoemulsions
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descriptionA composite contrast agent, a nanoemulsion bead with assembled gold nanospheres at the interface, is proposed to improve the specific contrast of photoacoustic molecular imaging. A phase transition in the bead's core is induced by absorption of a nanosecond laser pulse with a fairly low laser fluence (∼3.5 mJ/cm 2 ), creating a transient microbubble through dramatically enhanced thermal expansion. This generates nonlinear photoacoustic signals with more than 10 times larger amplitude compared to that of a linear agent with the same optical absorption. By applying a differential scheme similar to ultrasound pulse inversion, more than 40 dB contrast enhancement is demonstrated with suppression of background signals.
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abstractA composite contrast agent, a nanoemulsion bead with assembled gold nanospheres at the interface, is proposed to improve the specific contrast of photoacoustic molecular imaging. A phase transition in the bead's core is induced by absorption of a nanosecond laser pulse with a fairly low laser fluence (∼3.5 mJ/cm 2 ), creating a transient microbubble through dramatically enhanced thermal expansion. This generates nonlinear photoacoustic signals with more than 10 times larger amplitude compared to that of a linear agent with the same optical absorption. By applying a differential scheme similar to ultrasound pulse inversion, more than 40 dB contrast enhancement is demonstrated with suppression of background signals.
pubAmerican Institute of Physics
doi10.1063/1.4862461
date2014-01-20