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Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study

IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and t... Full description

Journal Title: JAMA Pediatrics 01 March 2016, Vol.170(3), pp.267-287
Main Author: Kyu, Hmwe H
Other Authors: Pinho, Christine , Wagner, Joseph A , Brown, Jonathan C , Bertozzi-Villa, Amelia , Charlson, Fiona J , Coffeng, Luc Edgar , Dandona, Lalit , Erskine, Holly E , Ferrari, Alize J , Fitzmaurice, Christina , Fleming, Thomas D , Forouzanfar, Mohammad H , Graetz, Nicholas , Guinovart, Caterina , Haagsma, Juanita , Higashi, Hideki , Kassebaum, Nicholas J , Larson, Heidi J , Lim, Stephen S , Mokdad, Ali H , Moradi-Lakeh, Maziar , Odell, Shaun V , Roth, Gregory A , Serina, Peter T , Stanaway, Jeffrey D , Misganaw, Awoke , Whiteford, Harvey A , Wolock, Timothy M , Wulf Hanson, Sarah , Abd-Allah, Foad , Abera, Semaw Ferede , Abu-Raddad, Laith J , Albuhairan, Fadia S , Amare, Azmeraw T , Antonio, Carl Abelardo T , Artaman, Al , Barker-Collo, Suzanne L , Barrero, Lope H , Benjet, Corina , Bensenor, Isabela M , Bhutta, Zulfiqar A , Bikbov, Boris , Brazinova, Alexandra , Campos-Nonato, Ismael , Castañeda-Orjuela, Carlos A , Catalá-López, Ferrán , Chowdhury, Rajiv , Cooper, Cyrus , Crump, John A , Dandona, Rakhi , Degenhardt, Louisa , Dellavalle, Robert P , Dharmaratne, Samath D , Faraon, Emerito Jose A , Feigin, Valery L , Fürst, Thomas , Geleijnse, Johanna M , Gessner, Bradford D , Gibney, Katherine B , Goto, Atsushi , Gunnell, David , Hankey, Graeme J , Hay, Roderick J , Hornberger, John C , Hosgood, H. Dean , Hu, Guoqing , Jacobsen, Kathryn H , Jayaraman, Sudha P , Jeemon, Panniyammakal , Jonas, Jost B , Karch, André , Kim, Daniel , Kim, Sungroul , Kokubo, Yoshihiro , Kuate Defo, Barthelemy , Kucuk Bicer, Burcu , Kumar, G. Anil , Larsson, Anders , Leasher, Janet L , Leung, Ricky , Li, Yongmei , Lipshultz, Steven E , Lopez, Alan D , Lotufo, Paulo A , Lunevicius, Raimundas , Lyons, Ronan A , Majdan, Marek , Malekzadeh, Reza , Mashal, Taufiq , Mason-Jones, Amanda J , Melaku, Yohannes Adama , Memish, Ziad A , Mendoza, Walter , Miller, Ted R , Mock, Charles N , Murray, Joseph , Nolte, Sandra , Oh, In-Hwan , Olusanya, Bolajoko Olubukunola , Ortblad, Katrina F , Park, Eun-Kee , Paternina Caicedo, Angel J , Patten, Scott B , Patton, George C , Pereira, David M , Perico, Norberto , Piel, Frédéric B , Polinder, Suzanne , Popova, Svetlana , Pourmalek, Farshad , Quistberg, D. Alex , Remuzzi, Giuseppe , Rodriguez, Alina , Rojas-Rueda, David , Rothenbacher, Dietrich , Rothstein, David H , Sanabria, Juan , Santos, Itamar S , Schwebel, David C , Sepanlou, Sadaf G , Shaheen, Amira , Shiri, Rahman , Shiue, Ivy , Skirbekk, Vegard , Sliwa, Karen , Sreeramareddy, Chandrashekhar T , Stein, Dan J , Steiner, Timothy J , Stovner, Lars Jacob , Sykes, Bryan L , Tabb, Karen M , Terkawi, Abdullah Sulieman , Thomson, Alan J , Thorne-Lyman, Andrew L , Towbin, Jeffrey Allen , Ukwaja, Kingsley Nnanna , Vasankari, Tommi , Venketasubramanian, Narayanaswamy , Vlassov, Vasiliy Victorovich , Vollset, Stein Emil , Weiderpass, Elisabete , Weintraub, Robert G , Werdecker, Andrea , Wilkinson, James D , Woldeyohannes, Solomon Meseret , Wolfe, Charles D. A , Yano, Yuichiro , Yip, Paul , Yonemoto, Naohiro , Yoon, Seok-Jun , Younis, Mustafa Z , Yu, Chuanhua , El Sayed Zaki, Maysaa , Naghavi, Mohsen , Murray, Christopher J. L , Vos, Theo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2168-6203 ; E-ISSN: 2168-6211 ; DOI: 10.1001/jamapediatrics.2015.4276
Link: http://dx.doi.org/10.1001/jamapediatrics.2015.4276
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recordid: ama2481809
title: Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
format: Article
creator:
  • Kyu, Hmwe H
  • Pinho, Christine
  • Wagner, Joseph A
  • Brown, Jonathan C
  • Bertozzi-Villa, Amelia
  • Charlson, Fiona J
  • Coffeng, Luc Edgar
  • Dandona, Lalit
  • Erskine, Holly E
  • Ferrari, Alize J
  • Fitzmaurice, Christina
  • Fleming, Thomas D
  • Forouzanfar, Mohammad H
  • Graetz, Nicholas
  • Guinovart, Caterina
  • Haagsma, Juanita
  • Higashi, Hideki
  • Kassebaum, Nicholas J
  • Larson, Heidi J
  • Lim, Stephen S
  • Mokdad, Ali H
  • Moradi-Lakeh, Maziar
  • Odell, Shaun V
  • Roth, Gregory A
  • Serina, Peter T
  • Stanaway, Jeffrey D
  • Misganaw, Awoke
  • Whiteford, Harvey A
  • Wolock, Timothy M
  • Wulf Hanson, Sarah
  • Abd-Allah, Foad
  • Abera, Semaw Ferede
  • Abu-Raddad, Laith J
  • Albuhairan, Fadia S
  • Amare, Azmeraw T
  • Antonio, Carl Abelardo T
  • Artaman, Al
  • Barker-Collo, Suzanne L
  • Barrero, Lope H
  • Benjet, Corina
  • Bensenor, Isabela M
  • Bhutta, Zulfiqar A
  • Bikbov, Boris
  • Brazinova, Alexandra
  • Campos-Nonato, Ismael
  • Castañeda-Orjuela, Carlos A
  • Catalá-López, Ferrán
  • Chowdhury, Rajiv
  • Cooper, Cyrus
  • Crump, John A
  • Dandona, Rakhi
  • Degenhardt, Louisa
  • Dellavalle, Robert P
  • Dharmaratne, Samath D
  • Faraon, Emerito Jose A
  • Feigin, Valery L
  • Fürst, Thomas
  • Geleijnse, Johanna M
  • Gessner, Bradford D
  • Gibney, Katherine B
  • Goto, Atsushi
  • Gunnell, David
  • Hankey, Graeme J
  • Hay, Roderick J
  • Hornberger, John C
  • Hosgood, H. Dean
  • Hu, Guoqing
  • Jacobsen, Kathryn H
  • Jayaraman, Sudha P
  • Jeemon, Panniyammakal
  • Jonas, Jost B
  • Karch, André
  • Kim, Daniel
  • Kim, Sungroul
  • Kokubo, Yoshihiro
  • Kuate Defo, Barthelemy
  • Kucuk Bicer, Burcu
  • Kumar, G. Anil
  • Larsson, Anders
  • Leasher, Janet L
  • Leung, Ricky
  • Li, Yongmei
  • Lipshultz, Steven E
  • Lopez, Alan D
  • Lotufo, Paulo A
  • Lunevicius, Raimundas
  • Lyons, Ronan A
  • Majdan, Marek
  • Malekzadeh, Reza
  • Mashal, Taufiq
  • Mason-Jones, Amanda J
  • Melaku, Yohannes Adama
  • Memish, Ziad A
  • Mendoza, Walter
  • Miller, Ted R
  • Mock, Charles N
  • Murray, Joseph
  • Nolte, Sandra
  • Oh, In-Hwan
  • Olusanya, Bolajoko Olubukunola
  • Ortblad, Katrina F
  • Park, Eun-Kee
  • Paternina Caicedo, Angel J
  • Patten, Scott B
  • Patton, George C
  • Pereira, David M
  • Perico, Norberto
  • Piel, Frédéric B
  • Polinder, Suzanne
  • Popova, Svetlana
  • Pourmalek, Farshad
  • Quistberg, D. Alex
  • Remuzzi, Giuseppe
  • Rodriguez, Alina
  • Rojas-Rueda, David
  • Rothenbacher, Dietrich
  • Rothstein, David H
  • Sanabria, Juan
  • Santos, Itamar S
  • Schwebel, David C
  • Sepanlou, Sadaf G
  • Shaheen, Amira
  • Shiri, Rahman
  • Shiue, Ivy
  • Skirbekk, Vegard
  • Sliwa, Karen
  • Sreeramareddy, Chandrashekhar T
  • Stein, Dan J
  • Steiner, Timothy J
  • Stovner, Lars Jacob
  • Sykes, Bryan L
  • Tabb, Karen M
  • Terkawi, Abdullah Sulieman
  • Thomson, Alan J
  • Thorne-Lyman, Andrew L
  • Towbin, Jeffrey Allen
  • Ukwaja, Kingsley Nnanna
  • Vasankari, Tommi
  • Venketasubramanian, Narayanaswamy
  • Vlassov, Vasiliy Victorovich
  • Vollset, Stein Emil
  • Weiderpass, Elisabete
  • Weintraub, Robert G
  • Werdecker, Andrea
  • Wilkinson, James D
  • Woldeyohannes, Solomon Meseret
  • Wolfe, Charles D. A
  • Yano, Yuichiro
  • Yip, Paul
  • Yonemoto, Naohiro
  • Yoon, Seok-Jun
  • Younis, Mustafa Z
  • Yu, Chuanhua
  • El Sayed Zaki, Maysaa
  • Naghavi, Mohsen
  • Murray, Christopher J. L
  • Vos, Theo
subjects:
  • Medicine
ispartof: JAMA Pediatrics, 01 March 2016, Vol.170(3), pp.267-287
description: IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged
language: eng
source:
identifier: ISSN: 2168-6203 ; E-ISSN: 2168-6211 ; DOI: 10.1001/jamapediatrics.2015.4276
fulltext: fulltext
issn:
  • 2168-6203
  • 21686203
  • 2168-6211
  • 21686211
url: Link


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titleGlobal and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
creatorKyu, Hmwe H ; Pinho, Christine ; Wagner, Joseph A ; Brown, Jonathan C ; Bertozzi-Villa, Amelia ; Charlson, Fiona J ; Coffeng, Luc Edgar ; Dandona, Lalit ; Erskine, Holly E ; Ferrari, Alize J ; Fitzmaurice, Christina ; Fleming, Thomas D ; Forouzanfar, Mohammad H ; Graetz, Nicholas ; Guinovart, Caterina ; Haagsma, Juanita ; Higashi, Hideki ; Kassebaum, Nicholas J ; Larson, Heidi J ; Lim, Stephen S ; Mokdad, Ali H ; Moradi-Lakeh, Maziar ; Odell, Shaun V ; Roth, Gregory A ; Serina, Peter T ; Stanaway, Jeffrey D ; Misganaw, Awoke ; Whiteford, Harvey A ; Wolock, Timothy M ; Wulf Hanson, Sarah ; Abd-Allah, Foad ; Abera, Semaw Ferede ; Abu-Raddad, Laith J ; Albuhairan, Fadia S ; Amare, Azmeraw T ; Antonio, Carl Abelardo T ; Artaman, Al ; Barker-Collo, Suzanne L ; Barrero, Lope H ; Benjet, Corina ; Bensenor, Isabela M ; Bhutta, Zulfiqar A ; Bikbov, Boris ; Brazinova, Alexandra ; Campos-Nonato, Ismael ; Castañeda-Orjuela, Carlos A ; Catalá-López, Ferrán ; Chowdhury, Rajiv ; Cooper, Cyrus ; Crump, John A ; Dandona, Rakhi ; Degenhardt, Louisa ; Dellavalle, Robert P ; Dharmaratne, Samath D ; Faraon, Emerito Jose A ; Feigin, Valery L ; Fürst, Thomas ; Geleijnse, Johanna M ; Gessner, Bradford D ; Gibney, Katherine B ; Goto, Atsushi ; Gunnell, David ; Hankey, Graeme J ; Hay, Roderick J ; Hornberger, John C ; Hosgood, H. Dean ; Hu, Guoqing ; Jacobsen, Kathryn H ; Jayaraman, Sudha P ; Jeemon, Panniyammakal ; Jonas, Jost B ; Karch, André ; Kim, Daniel ; Kim, Sungroul ; Kokubo, Yoshihiro ; Kuate Defo, Barthelemy ; Kucuk Bicer, Burcu ; Kumar, G. Anil ; Larsson, Anders ; Leasher, Janet L ; Leung, Ricky ; Li, Yongmei ; Lipshultz, Steven E ; Lopez, Alan D ; Lotufo, Paulo A ; Lunevicius, Raimundas ; Lyons, Ronan A ; Majdan, Marek ; Malekzadeh, Reza ; Mashal, Taufiq ; Mason-Jones, Amanda J ; Melaku, Yohannes Adama ; Memish, Ziad A ; Mendoza, Walter ; Miller, Ted R ; Mock, Charles N ; Murray, Joseph ; Nolte, Sandra ; Oh, In-Hwan ; Olusanya, Bolajoko Olubukunola ; Ortblad, Katrina F ; Park, Eun-Kee ; Paternina Caicedo, Angel J ; Patten, Scott B ; Patton, George C ; Pereira, David M ; Perico, Norberto ; Piel, Frédéric B ; Polinder, Suzanne ; Popova, Svetlana ; Pourmalek, Farshad ; Quistberg, D. Alex ; Remuzzi, Giuseppe ; Rodriguez, Alina ; Rojas-Rueda, David ; Rothenbacher, Dietrich ; Rothstein, David H ; Sanabria, Juan ; Santos, Itamar S ; Schwebel, David C ; Sepanlou, Sadaf G ; Shaheen, Amira ; Shiri, Rahman ; Shiue, Ivy ; Skirbekk, Vegard ; Sliwa, Karen ; Sreeramareddy, Chandrashekhar T ; Stein, Dan J ; Steiner, Timothy J ; Stovner, Lars Jacob ; Sykes, Bryan L ; Tabb, Karen M ; Terkawi, Abdullah Sulieman ; Thomson, Alan J ; Thorne-Lyman, Andrew L ; Towbin, Jeffrey Allen ; Ukwaja, Kingsley Nnanna ; Vasankari, Tommi ; Venketasubramanian, Narayanaswamy ; Vlassov, Vasiliy Victorovich ; Vollset, Stein Emil ; Weiderpass, Elisabete ; Weintraub, Robert G ; Werdecker, Andrea ; Wilkinson, James D ; Woldeyohannes, Solomon Meseret ; Wolfe, Charles D. A ; Yano, Yuichiro ; Yip, Paul ; Yonemoto, Naohiro ; Yoon, Seok-Jun ; Younis, Mustafa Z ; Yu, Chuanhua ; El Sayed Zaki, Maysaa ; Naghavi, Mohsen ; Murray, Christopher J. L ; Vos, Theo
ispartofJAMA Pediatrics, 01 March 2016, Vol.170(3), pp.267-287
identifier
subjectMedicine
description

IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. CONCLUSIONS AND RELEVANCE: Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

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0Kyu, Hmwe H
1Pinho, Christine
2Wagner, Joseph A
3Brown, Jonathan C
4Bertozzi-Villa, Amelia
5Charlson, Fiona J
6Coffeng, Luc Edgar
7Dandona, Lalit
8Erskine, Holly E
9Ferrari, Alize J
10Fitzmaurice, Christina
11Fleming, Thomas D
12Forouzanfar, Mohammad H
13Graetz, Nicholas
14Guinovart, Caterina
15Haagsma, Juanita
16Higashi, Hideki
17Kassebaum, Nicholas J
18Larson, Heidi J
19Lim, Stephen S
20Mokdad, Ali H
21Moradi-Lakeh, Maziar
22Odell, Shaun V
23Roth, Gregory A
24Serina, Peter T
25Stanaway, Jeffrey D
26Misganaw, Awoke
27Whiteford, Harvey A
28Wolock, Timothy M
29Wulf Hanson, Sarah
30Abd-Allah, Foad
31Abera, Semaw Ferede
32Abu-Raddad, Laith J
33Albuhairan, Fadia S
34Amare, Azmeraw T
35Antonio, Carl Abelardo T
36Artaman, Al
37Barker-Collo, Suzanne L
38Barrero, Lope H
39Benjet, Corina
40Bensenor, Isabela M
41Bhutta, Zulfiqar A
42Bikbov, Boris
43Brazinova, Alexandra
44Campos-Nonato, Ismael
45Castañeda-Orjuela, Carlos A
46Catalá-López, Ferrán
47Chowdhury, Rajiv
48Cooper, Cyrus
49Crump, John A
50Dandona, Rakhi
51Degenhardt, Louisa
52Dellavalle, Robert P
53Dharmaratne, Samath D
54Faraon, Emerito Jose A
55Feigin, Valery L
56Fürst, Thomas
57Geleijnse, Johanna M
58Gessner, Bradford D
59Gibney, Katherine B
60Goto, Atsushi
61Gunnell, David
62Hankey, Graeme J
63Hay, Roderick J
64Hornberger, John C
65Hosgood, H. Dean
66Hu, Guoqing
67Jacobsen, Kathryn H
68Jayaraman, Sudha P
69Jeemon, Panniyammakal
70Jonas, Jost B
71Karch, André
72Kim, Daniel
73Kim, Sungroul
74Kokubo, Yoshihiro
75Kuate Defo, Barthelemy
76Kucuk Bicer, Burcu
77Kumar, G. Anil
78Larsson, Anders
79Leasher, Janet L
80Leung, Ricky
81Li, Yongmei
82Lipshultz, Steven E
83Lopez, Alan D
84Lotufo, Paulo A
85Lunevicius, Raimundas
86Lyons, Ronan A
87Majdan, Marek
88Malekzadeh, Reza
89Mashal, Taufiq
90Mason-Jones, Amanda J
91Melaku, Yohannes Adama
92Memish, Ziad A
93Mendoza, Walter
94Miller, Ted R
95Mock, Charles N
96Murray, Joseph
97Nolte, Sandra
98Oh, In-Hwan
99Olusanya, Bolajoko Olubukunola
100...
titleGlobal and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
description

IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. CONCLUSIONS AND RELEVANCE: Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

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titleGlobal and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
authorKyu, Hmwe H ; Pinho, Christine ; Wagner, Joseph A ; Brown, Jonathan C ; Bertozzi-Villa, Amelia ; Charlson, Fiona J ; Coffeng, Luc Edgar ; Dandona, Lalit ; Erskine, Holly E ; Ferrari, Alize J ; Fitzmaurice, Christina ; Fleming, Thomas D ; Forouzanfar, Mohammad H ; Graetz, Nicholas ; Guinovart, Caterina ; Haagsma, Juanita ; Higashi, Hideki ; Kassebaum, Nicholas J ; Larson, Heidi J ; Lim, Stephen S ; Mokdad, Ali H ; Moradi-Lakeh, Maziar ; Odell, Shaun V ; Roth, Gregory A ; Serina, Peter T ; Stanaway, Jeffrey D ; Misganaw, Awoke ; Whiteford, Harvey A ; Wolock, Timothy M ; Wulf Hanson, Sarah ; Abd-Allah, Foad ; Abera, Semaw Ferede ; Abu-Raddad, Laith J ; Albuhairan, Fadia S ; Amare, Azmeraw T ; Antonio, Carl Abelardo T ; Artaman, Al ; Barker-Collo, Suzanne L ; Barrero, Lope H ; Benjet, Corina ; Bensenor, Isabela M ; Bhutta, Zulfiqar A ; Bikbov, Boris ; Brazinova, Alexandra ; Campos-Nonato, Ismael ; Castañeda-Orjuela, Carlos A ; Catalá-López, Ferrán ; Chowdhury, Rajiv ; Cooper, Cyrus ; Crump, John A ; Dandona, Rakhi ; Degenhardt, Louisa ; Dellavalle, Robert P ; Dharmaratne, Samath D ; Faraon, Emerito Jose A ; Feigin, Valery L ; Fürst, Thomas ; Geleijnse, Johanna M ; Gessner, Bradford D ; Gibney, Katherine B ; Goto, Atsushi ; Gunnell, David ; Hankey, Graeme J ; Hay, Roderick J ; Hornberger, John C ; Hosgood, H. Dean ; Hu, Guoqing ; Jacobsen, Kathryn H ; Jayaraman, Sudha P ; Jeemon, Panniyammakal ; Jonas, Jost B ; Karch, André ; Kim, Daniel ; Kim, Sungroul ; Kokubo, Yoshihiro ; Kuate Defo, Barthelemy ; Kucuk Bicer, Burcu ; Kumar, G. Anil ; Larsson, Anders ; Leasher, Janet L ; Leung, Ricky ; Li, Yongmei ; Lipshultz, Steven E ; Lopez, Alan D ; Lotufo, Paulo A ; Lunevicius, Raimundas ; Lyons, Ronan A ; Majdan, Marek ; Malekzadeh, Reza ; Mashal, Taufiq ; Mason-Jones, Amanda J ; Melaku, Yohannes Adama ; Memish, Ziad A ; Mendoza, Walter ; Miller, Ted R ; Mock, Charles N ; Murray, Joseph ; Nolte, Sandra ; Oh, In-Hwan ; Olusanya, Bolajoko Olubukunola ; Ortblad, Katrina F ; Park, Eun-Kee ; Paternina Caicedo, Angel J ; Patten, Scott B ; Patton, George C ; Pereira, David M ; Perico, Norberto ; Piel, Frédéric B ; Polinder, Suzanne ; Popova, Svetlana ; Pourmalek, Farshad ; Quistberg, D. Alex ; Remuzzi, Giuseppe ; Rodriguez, Alina ; Rojas-Rueda, David ; Rothenbacher, Dietrich ; Rothstein, David H ; Sanabria, Juan ; Santos, Itamar S ; Schwebel, David C ; Sepanlou, Sadaf G ; Shaheen, Amira ; Shiri, Rahman ; Shiue, Ivy ; Skirbekk, Vegard ; Sliwa, Karen ; Sreeramareddy, Chandrashekhar T ; Stein, Dan J ; Steiner, Timothy J ; Stovner, Lars Jacob ; Sykes, Bryan L ; Tabb, Karen M ; Terkawi, Abdullah Sulieman ; Thomson, Alan J ; Thorne-Lyman, Andrew L ; Towbin, Jeffrey Allen ; Ukwaja, Kingsley Nnanna ; Vasankari, Tommi ; Venketasubramanian, Narayanaswamy ; Vlassov, Vasiliy Victorovich ; Vollset, Stein Emil ; Weiderpass, Elisabete ; Weintraub, Robert G ; Werdecker, Andrea ; Wilkinson, James D ; Woldeyohannes, Solomon Meseret ; Wolfe, Charles D. A ; Yano, Yuichiro ; Yip, Paul ; Yonemoto, Naohiro ; Yoon, Seok-Jun ; Younis, Mustafa Z ; Yu, Chuanhua ; El Sayed Zaki, Maysaa ; Naghavi, Mohsen ; Murray, Christopher J. L ; Vos, Theo
creationdate20160301
lso0120160301
facets
frbrgroupid9165074564873399596
frbrtype5
languageeng
topicMedicine
collection
0The JAMA Network (American Medical Association)
1American Medical Association Journals
prefilterarticles
rsrctypearticles
creatorcontrib
0Kyu, Hmwe H
1Pinho, Christine
2Wagner, Joseph A
3Brown, Jonathan C
4Bertozzi-Villa, Amelia
5Charlson, Fiona J
6Coffeng, Luc Edgar
7Dandona, Lalit
8Erskine, Holly E
9Ferrari, Alize J
10Fitzmaurice, Christina
11Fleming, Thomas D
12Forouzanfar, Mohammad H
13Graetz, Nicholas
14Guinovart, Caterina
15Haagsma, Juanita
16Higashi, Hideki
17Kassebaum, Nicholas J
18Larson, Heidi J
19Lim, Stephen S
20Mokdad, Ali H
21Moradi-Lakeh, Maziar
22Odell, Shaun V
23Roth, Gregory A
24Serina, Peter T
25Stanaway, Jeffrey D
26Misganaw, Awoke
27Whiteford, Harvey A
28Wolock, Timothy M
29Wulf Hanson, Sarah
30Abd-Allah, Foad
31Abera, Semaw Ferede
32Abu-Raddad, Laith J
33Albuhairan, Fadia S
34Amare, Azmeraw T
35Antonio, Carl Abelardo T
36Artaman, Al
37Barker-Collo, Suzanne L
38Barrero, Lope H
39Benjet, Corina
40Bensenor, Isabela M
41Bhutta, Zulfiqar A
42Bikbov, Boris
43Brazinova, Alexandra
44Campos-Nonato, Ismael
45Castañeda-Orjuela, Carlos A
46Catalá-López, Ferrán
47Chowdhury, Rajiv
48Cooper, Cyrus
49Crump, John A
50Dandona, Rakhi
51Degenhardt, Louisa
52Dellavalle, Robert P
53Dharmaratne, Samath D
54Faraon, Emerito Jose A
55Feigin, Valery L
56Fürst, Thomas
57Geleijnse, Johanna M
58Gessner, Bradford D
59Gibney, Katherine B
60Goto, Atsushi
61Gunnell, David
62Hankey, Graeme J
63Hay, Roderick J
64Hornberger, John C
65Hosgood, H. Dean
66Hu, Guoqing
67Jacobsen, Kathryn H
68Jayaraman, Sudha P
69Jeemon, Panniyammakal
70Jonas, Jost B
71Karch, André
72Kim, Daniel
73Kim, Sungroul
74Kokubo, Yoshihiro
75Kuate Defo, Barthelemy
76Kucuk Bicer, Burcu
77Kumar, G. Anil
78Larsson, Anders
79Leasher, Janet L
80Leung, Ricky
81Li, Yongmei
82Lipshultz, Steven E
83Lopez, Alan D
84Lotufo, Paulo A
85Lunevicius, Raimundas
86Lyons, Ronan A
87Majdan, Marek
88Malekzadeh, Reza
89Mashal, Taufiq
90Mason-Jones, Amanda J
91Melaku, Yohannes Adama
92Memish, Ziad A
93Mendoza, Walter
94Miller, Ted R
95Mock, Charles N
96Murray, Joseph
97Nolte, Sandra
98Oh, In-Hwan
99Olusanya, Bolajoko Olubukunola
100...
jtitleJAMA Pediatrics
creationdate2016
toplevelpeer_reviewed
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delcategoryRemote Search Resource
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aulast
0Kyu
1Pinho
2Wagner
3Brown
4Bertozzi-Villa
5Charlson
6Coffeng
7Dandona
8Erskine
9Ferrari
10Fitzmaurice
11Fleming
12Forouzanfar
13Graetz
14Guinovart
15Haagsma
16Higashi
17Kassebaum
18Larson
19Lim
20Mokdad
21Moradi-Lakeh
22Odell
23Roth
24Serina
25Stanaway
26Misganaw
27Whiteford
28Wolock
29Wulf Hanson
30Abd-Allah
31Abera
32Abu-Raddad
33Albuhairan
34Amare
35Antonio
36Artaman
37Barker-Collo
38Barrero
39Benjet
40Bensenor
41Bhutta
42Bikbov
43Brazinova
44Campos-Nonato
45Castañeda-Orjuela
46Catalá-López
47Chowdhury
48Cooper
49Crump
50Degenhardt
51Dellavalle
52Dharmaratne
53Faraon
54Feigin
55Fürst
56Geleijnse
57Gessner
58Gibney
59Goto
60Gunnell
61Hankey
62Hay
63Hornberger
64Hosgood
65Hu
66Jacobsen
67Jayaraman
68Jeemon
69Jonas
70Karch
71Kim
72Kokubo
73Kuate Defo
74Kucuk Bicer
75Kumar
76Larsson
77Leasher
78Leung
79Li
80Lipshultz
81Lopez
82Lotufo
83Lunevicius
84Lyons
85Majdan
86Malekzadeh
87Mashal
88Mason-Jones
89Melaku
90Memish
91Mendoza
92Miller
93Mock
94Murray
95Nolte
96Oh
97Olusanya
98Ortblad
99Park
100...
aufirst
0Hmwe H
1Christine
2Joseph A
3Jonathan C
4Amelia
5Fiona J
6Luc Edgar
7Lalit
8Holly E
9Alize J
10Christina
11Thomas D
12Mohammad H
13Nicholas
14Caterina
15Juanita
16Hideki
17Nicholas J
18Heidi J
19Stephen S
20Ali H
21Maziar
22Shaun V
23Gregory A
24Peter T
25Jeffrey D
26Awoke
27Harvey A
28Timothy M
29Sarah
30Foad
31Semaw Ferede
32Laith J
33Fadia S
34Azmeraw T
35Carl Abelardo T
36Al
37Suzanne L
38Lope H
39Corina
40Isabela M
41Zulfiqar A
42Boris
43Alexandra
44Ismael
45Carlos A
46Ferrán
47Rajiv
48Cyrus
49John A
50Rakhi
51Louisa
52Robert P
53Samath D
54Emerito Jose A
55Valery L
56Thomas
57Johanna M
58Bradford D
59Katherine B
60Atsushi
61David
62Graeme J
63Roderick J
64John C
65H. Dean
66Guoqing
67Kathryn H
68Sudha P
69Panniyammakal
70Jost B
71André
72Daniel
73Sungroul
74Yoshihiro
75Barthelemy
76Burcu
77G. Anil
78Anders
79Janet L
80Ricky
81Yongmei
82Steven E
83Alan D
84Paulo A
85Raimundas
86Ronan A
87Marek
88Reza
89Taufiq
90Amanda J
91Yohannes Adama
92Ziad A
93Walter
94Ted R
95Charles N
96Joseph
97Sandra
98In-Hwan
99Bolajoko Olubukunola
100...
auinitH
auinit1H
au
0Kyu, Hmwe H
1Pinho, Christine
2Wagner, Joseph A
3Brown, Jonathan C
4Bertozzi-Villa, Amelia
5Charlson, Fiona J
6Coffeng, Luc Edgar
7Dandona, Lalit
8Erskine, Holly E
9Ferrari, Alize J
10Fitzmaurice, Christina
11Fleming, Thomas D
12Forouzanfar, Mohammad H
13Graetz, Nicholas
14Guinovart, Caterina
15Haagsma, Juanita
16Higashi, Hideki
17Kassebaum, Nicholas J
18Larson, Heidi J
19Lim, Stephen S
20Mokdad, Ali H
21Moradi-Lakeh, Maziar
22Odell, Shaun V
23Roth, Gregory A
24Serina, Peter T
25Stanaway, Jeffrey D
26Misganaw, Awoke
27Whiteford, Harvey A
28Wolock, Timothy M
29Wulf Hanson, Sarah
30Abd-Allah, Foad
31Abera, Semaw Ferede
32Abu-Raddad, Laith J
33Albuhairan, Fadia S
34Amare, Azmeraw T
35Antonio, Carl Abelardo T
36Artaman, Al
37Barker-Collo, Suzanne L
38Barrero, Lope H
39Benjet, Corina
40Bensenor, Isabela M
41Bhutta, Zulfiqar A
42Bikbov, Boris
43Brazinova, Alexandra
44Campos-Nonato, Ismael
45Castañeda-Orjuela, Carlos A
46Catalá-López, Ferrán
47Chowdhury, Rajiv
48Cooper, Cyrus
49Crump, John A
50Dandona, Rakhi
51Degenhardt, Louisa
52Dellavalle, Robert P
53Dharmaratne, Samath D
54Faraon, Emerito Jose A
55Feigin, Valery L
56Fürst, Thomas
57Geleijnse, Johanna M
58Gessner, Bradford D
59Gibney, Katherine B
60Goto, Atsushi
61Gunnell, David
62Hankey, Graeme J
63Hay, Roderick J
64Hornberger, John C
65Hosgood, H. Dean
66Hu, Guoqing
67Jacobsen, Kathryn H
68Jayaraman, Sudha P
69Jeemon, Panniyammakal
70Jonas, Jost B
71Karch, André
72Kim, Daniel
73Kim, Sungroul
74Kokubo, Yoshihiro
75Kuate Defo, Barthelemy
76Kucuk Bicer, Burcu
77Kumar, G. Anil
78Larsson, Anders
79Leasher, Janet L
80Leung, Ricky
81Li, Yongmei
82Lipshultz, Steven E
83Lopez, Alan D
84Lotufo, Paulo A
85Lunevicius, Raimundas
86Lyons, Ronan A
87Majdan, Marek
88Malekzadeh, Reza
89Mashal, Taufiq
90Mason-Jones, Amanda J
91Melaku, Yohannes Adama
92Memish, Ziad A
93Mendoza, Walter
94Miller, Ted R
95Mock, Charles N
96Murray, Joseph
97Nolte, Sandra
98Oh, In-Hwan
99Olusanya, Bolajoko Olubukunola
100...
atitleGlobal and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
jtitleJAMA Pediatrics
risdate20160301
volume170
issue3
spage267
epage287
pages267-287
issn2168-6203
eissn2168-6211
formatjournal
genrearticle
ristypeJOUR
abstract

IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. CONCLUSIONS AND RELEVANCE: Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

pubAmerican Medical Association
doi10.1001/jamapediatrics.2015.4276
date2016-03-01