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The Psychology of Psychiatric Genetics: Evidence That Positive Emotions in Females Moderate Genetic Sensitivity to Social Stress Associated With the BDNF Val 66 Met Polymorphism

Previous work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val 66 Met genotype may med... Full description

Journal Title: Journal of Abnormal Psychology 2008, Vol.117(3), pp.699-704
Main Author: Wichers, Marieke
Other Authors: Kenis, Gunter , Jacobs, Nele , Myin-Germeys, Inez , Schruers, Koen , Mengelers, Ron , Delespaul, Philippe , Derom, Catherine , Vlietinck, Robert , Van Os, Jim
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0021-843X ; E-ISSN: 1939-1846 ; DOI: 10.1037/a0012909
Link: http://dx.doi.org/10.1037/a0012909
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recordid: apa_articles10.1037/a0012909
title: The Psychology of Psychiatric Genetics: Evidence That Positive Emotions in Females Moderate Genetic Sensitivity to Social Stress Associated With the BDNF Val 66 Met Polymorphism
format: Article
creator:
  • Wichers, Marieke
  • Kenis, Gunter
  • Jacobs, Nele
  • Myin-Germeys, Inez
  • Schruers, Koen
  • Mengelers, Ron
  • Delespaul, Philippe
  • Derom, Catherine
  • Vlietinck, Robert
  • Van Os, Jim
subjects:
  • Bdnf Valmet
  • Gene–Environment Interaction
  • Stress Sensitivity
  • Experience Sampling Method (Esm)
  • Positive Emotions
ispartof: Journal of Abnormal Psychology, 2008, Vol.117(3), pp.699-704
description: Previous work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val 66 Met genotype may mediate genetic effects on stress sensitivity, conditional on the level of concurrent positive emotions. Subjects ( n = 446) participated in a momentary assessment study, collecting appraisals of stress and affect in the flow of daily life. Multilevel regression analyses examined moderation of daily life stress-induced negative affect (NA) by BDNF genotype, and to what degree this was conditional on concurrent positive emotions. Results showed that heterozygous BDNF “Met” carriers exhibited an increased NA response to social stress compared with “Val/Val” subjects. Positive emotions at the time of the stressor decreased BDNF genetic moderation of the NA response to social stress in a dose-response fashion. This effect was most pronounced in BDNF Met carriers. Thus, the impact of BDNF genotype on stress sensitivity is conditional on the experience of positive emotions. Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders.
language: eng
source:
identifier: ISSN: 0021-843X ; E-ISSN: 1939-1846 ; DOI: 10.1037/a0012909
fulltext: fulltext
issn:
  • 0021-843X
  • 0021843X
  • 1939-1846
  • 19391846
url: Link


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titleThe Psychology of Psychiatric Genetics: Evidence That Positive Emotions in Females Moderate Genetic Sensitivity to Social Stress Associated With the BDNF Val 66 Met Polymorphism
creatorWichers, Marieke ; Kenis, Gunter ; Jacobs, Nele ; Myin-Germeys, Inez ; Schruers, Koen ; Mengelers, Ron ; Delespaul, Philippe ; Derom, Catherine ; Vlietinck, Robert ; Van Os, Jim
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subjectBdnf Valmet ; Gene–Environment Interaction ; Stress Sensitivity ; Experience Sampling Method (Esm) ; Positive Emotions
descriptionPrevious work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val 66 Met genotype may mediate genetic effects on stress sensitivity, conditional on the level of concurrent positive emotions. Subjects ( n = 446) participated in a momentary assessment study, collecting appraisals of stress and affect in the flow of daily life. Multilevel regression analyses examined moderation of daily life stress-induced negative affect (NA) by BDNF genotype, and to what degree this was conditional on concurrent positive emotions. Results showed that heterozygous BDNF “Met” carriers exhibited an increased NA response to social stress compared with “Val/Val” subjects. Positive emotions at the time of the stressor decreased BDNF genetic moderation of the NA response to social stress in a dose-response fashion. This effect was most pronounced in BDNF Met carriers. Thus, the impact of BDNF genotype on stress sensitivity is conditional on the experience of positive emotions. Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders.
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titleThe Psychology of Psychiatric Genetics: Evidence That Positive Emotions in Females Moderate Genetic Sensitivity to Social Stress Associated With the BDNF Val 66 Met Polymorphism
descriptionPrevious work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val 66 Met genotype may mediate genetic effects on stress sensitivity, conditional on the level of concurrent positive emotions. Subjects ( n = 446) participated in a momentary assessment study, collecting appraisals of stress and affect in the flow of daily life. Multilevel regression analyses examined moderation of daily life stress-induced negative affect (NA) by BDNF genotype, and to what degree this was conditional on concurrent positive emotions. Results showed that heterozygous BDNF “Met” carriers exhibited an increased NA response to social stress compared with “Val/Val” subjects. Positive emotions at the time of the stressor decreased BDNF genetic moderation of the NA response to social stress in a dose-response fashion. This effect was most pronounced in BDNF Met carriers. Thus, the impact of BDNF genotype on stress sensitivity is conditional on the experience of positive emotions. Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders.
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abstractPrevious work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val 66 Met genotype may mediate genetic effects on stress sensitivity, conditional on the level of concurrent positive emotions. Subjects ( n = 446) participated in a momentary assessment study, collecting appraisals of stress and affect in the flow of daily life. Multilevel regression analyses examined moderation of daily life stress-induced negative affect (NA) by BDNF genotype, and to what degree this was conditional on concurrent positive emotions. Results showed that heterozygous BDNF “Met” carriers exhibited an increased NA response to social stress compared with “Val/Val” subjects. Positive emotions at the time of the stressor decreased BDNF genetic moderation of the NA response to social stress in a dose-response fashion. This effect was most pronounced in BDNF Met carriers. Thus, the impact of BDNF genotype on stress sensitivity is conditional on the experience of positive emotions. Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders.
pubAmerican Psychological Association
doi10.1037/a0012909
date2008-08