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Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and... Full description

Journal Title: Ripke Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. A.; Stahl, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wormley, Brandon K.; Simon Xi, Hualin; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Trust Case-Control Consortium, Wellcome; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (7510),
Main Author: Ripke, Stephan
Other Authors: Neale, Benjamin M. , Corvin, Aiden , Walters, James T. R. , Farh, Kai-How , Holmans, Peter A. , Lee, Phil , Bulik-Sullivan, Brendan , Collier, David A. , Huang, Hailiang , Pers, Tune H. , Agartz, Ingrid , Agerbo, Esben , Albus, Margot , Alexander, Madeline , Amin, Farooq , Bacanu, Silviu A. , Begemann, Martin , Belliveau Jr, Richard A. , Bene, Judit , Bergen, Sarah E. , Bevilacqua, Elizabeth , Bigdeli, Tim B. , Black, Donald W. , Bruggeman, Richard , Buccola, Nancy G. , Buckner, Randy L. , Byerley, William , Cahn, Wiepke , Cai, Guiqing , Campion, Dominique , Cantor, Rita M. , Carr, Vaughan J. , Carrera, Noa , Catts, Stanley V. , Chambert, Kimberly D. , Chan, Raymond C. K. , Chen, Ronald Y. L. , Chen, Eric Y. H. , Cheng, Wei , Cheung, Eric F. C. , Ann Chong, Siow , Robert Cloninger, C. , Cohen, David , Cohen, Nadine , Cormican, Paul , Craddock, Nick , Crowley, James J. , Curtis, David , Davidson, Michael , Davis, Kenneth L. , Degenhardt, Franziska , Del Favero, Jurgen , Demontis, Ditte , Dikeos, Dimitris , Dinan, Timothy , Djurovic, Srdjan , Donohoe, Gary , Drapeau, Elodie , Duan, Jubao , Dudbridge, Frank , Durmishi, Naser , Eichhammer, Peter , Eriksson, Johan , Escott-Price, Valentina , Essioux, Laurent , Fanous, Ayman H. , Farrell, Martilias S. , Frank, Josef , Franke, Lude , Freedman, Robert , Freimer, Nelson B. , Friedl, Marion , Friedman, Joseph I. , Fromer, Menachem , Genovese, Giulio , Georgieva, Lyudmila , Giegling, Ina , Giusti-Rodríguez, Paola , Godard, Stephanie , Goldstein, Jacqueline I. , Golimbet, Vera , Gopal, Srihari , Gratten, Jacob , De Haan, Lieuwe , Hammer, Christian , Hamshere, Marian L. , Hansen, Mark , Hansen, Thomas , Haroutunian, Vahram , Hartmann, Annette M. , Henskens, Frans A. , Herms, Stefan , Hirschhorn, Joel N. , Hoffmann, Per , Hofman, Andrea , Hollegaard, Mads V. , Hougaard, David M. , Ikeda, Masashi , Joa, Inge , Julià, Antonio , Kahn, René S. , Kalaydjieva, Luba , Karachanak-Yankova, Sena , Karjalainen, Juha , Kavanagh, David , Keller, Matthew C. , Kennedy, James L. , Khrunin, Andrey , Kim, Yunjung , Klovins, Janis , Knowles, James A. , Konte, Bettina , Kucinskas, Vaidutis , Ausrele Kucinskiene, Zita , Kuzelova-Ptackova, Hana , Kähler, Anna K. , Laurent, Claudine , Lee Chee Keong, Jimmy , Hong Lee, S. , Legge, Sophie E. , Lerer, Bernard , Li, Miaoxin , Li, Tao , Liang, Kung-Yee , Lieberman, Jeffrey , Limborska, Svetlana , Loughland, Carmel M. , Lubinski, Jan , Lönnqvist, Jouko , Macek Jr, Milan , Magnusson, Patrik K. E. , Maher, Brion S. , Maier, Wolfgang , Mallet, Jacques , Marsal, Sara , Mattheisen, Manuel , Mattingsdal, Morten , Mccarley, Robert W. , Mcdonald, Colm , Mcintosh, Andrew M. , Meier, Sandra , Meijer, Carin J. , Melegh, Bela , Melle, Ingrid , Mesholam-Gately, Raquelle I. , Metspalu, Andres , Michie, Patricia T. , Milani, Lili , Milanova, Vihra , Mokrab, Younes , Morris, Derek W. , Mors, Ole , Murphy, Kieran C. , Murray, Robin M. , Myin-Germeys, Inez , Müller-Myhsok, Bertram , Nelis, Mari , Nenadic, Igor , Nertney, Deborah A. , Nestadt, Gerald , Nicodemus, Kristin K. , Nikitina-Zake, Liene , Nisenbaum, Laura , Nordin, Annelie , O’callaghan, Eadbhard , O’dushlaine, Colm , O’neill, F. Anthony , Oh, Sang-Yun , Olincy, Ann , Olsen, Line , Van Os, Jim , Endophenotypes International Consortium, Psychosis , Pantelis, Christos , Papadimitriou, George N. , Papiol, Sergi , Parkhomenko, Elena , Pato, Michele T. , Paunio, Tiina , Pejovic-Milovancevic, Milica , Perkins, Diana O. , Pietiläinen, Olli , Pimm, Jonathan , Pocklington, Andrew J. , Powell, John , Price, Alkes , Pulver, Ann E. , Purcell, Shaun M. , Quested, Digby , Rasmussen, Henrik B. , Reichenberg, Abraham , Reimers, Mark A. , Richards, Alexander L. , Roffman, Joshua L. , Roussos, Panos , Ruderfer, Douglas M. , Salomaa, Veikko , Sanders, Alan R. , Schall, Ulrich , Schubert, Christian R. , Schulze, Thomas G. , Schwab, Sibylle G. , Scolnick, Edward M. , Scott, Rodney J. , Seidman, Larry J. , Shi, Jianxin , Sigurdsson, Engilbert , Silagadze, Teimuraz , Silverman, Jeremy M. , Sim, Kang , Slominsky, Petr , Smoller, Jordan W. , So, Hon-Cheong , Spencer, Chrisc. A. , Stahl, Eli A. , Stefansson, Hreinn , Steinberg, Stacy , Stogmann, Elisabeth , Straub, Richard E. , Strengman, Eric , Strohmaier, Jana , Scott Stroup, T. , Subramaniam, Mythily , Suvisaari, Jaana , Svrakic, Dragan M. , Szatkiewicz, Jin P. , Söderman, Erik , Thirumalai, Srinivas , Toncheva, Draga , Tosato, Sarah , Veijola, Juha , Waddington, John , Walsh, Dermot , Wang, Dai , Wang, Qiang , Webb, Bradley T. , Weiser, Mark , Wildenauer, Dieter B. , Williams, Nigel M. , Williams, Stephanie , Witt, Stephanie H. , Wolen, Aaron R. , Wong, Emily H. M. , Wormley, Brandon K. , Simon Xi, Hualin , Zai, Clement C. , Zheng, Xuebin , Zimprich, Fritz , Wray, Naomi R. , Stefansson, Kari
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ID: DOI: 10.1038/nature13595
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recordid: aran10379/13659
title: Biological insights from 108 schizophrenia-associated genetic loci
format: Article
creator:
  • Ripke, Stephan
  • Neale, Benjamin M.
  • Corvin, Aiden
  • Walters, James T. R.
  • Farh, Kai-How
  • Holmans, Peter A.
  • Lee, Phil
  • Bulik-Sullivan, Brendan
  • Collier, David A.
  • Huang, Hailiang
  • Pers, Tune H.
  • Agartz, Ingrid
  • Agerbo, Esben
  • Albus, Margot
  • Alexander, Madeline
  • Amin, Farooq
  • Bacanu, Silviu A.
  • Begemann, Martin
  • Belliveau Jr, Richard A.
  • Bene, Judit
  • Bergen, Sarah E.
  • Bevilacqua, Elizabeth
  • Bigdeli, Tim B.
  • Black, Donald W.
  • Bruggeman, Richard
  • Buccola, Nancy G.
  • Buckner, Randy L.
  • Byerley, William
  • Cahn, Wiepke
  • Cai, Guiqing
  • Campion, Dominique
  • Cantor, Rita M.
  • Carr, Vaughan J.
  • Carrera, Noa
  • Catts, Stanley V.
  • Chambert, Kimberly D.
  • Chan, Raymond C. K.
  • Chen, Ronald Y. L.
  • Chen, Eric Y. H.
  • Cheng, Wei
  • Cheung, Eric F. C.
  • Ann Chong, Siow
  • Robert Cloninger, C.
  • Cohen, David
  • Cohen, Nadine
  • Cormican, Paul
  • Craddock, Nick
  • Crowley, James J.
  • Curtis, David
  • Davidson, Michael
  • Davis, Kenneth L.
  • Degenhardt, Franziska
  • Del Favero, Jurgen
  • Demontis, Ditte
  • Dikeos, Dimitris
  • Dinan, Timothy
  • Djurovic, Srdjan
  • Donohoe, Gary
  • Drapeau, Elodie
  • Duan, Jubao
  • Dudbridge, Frank
  • Durmishi, Naser
  • Eichhammer, Peter
  • Eriksson, Johan
  • Escott-Price, Valentina
  • Essioux, Laurent
  • Fanous, Ayman H.
  • Farrell, Martilias S.
  • Frank, Josef
  • Franke, Lude
  • Freedman, Robert
  • Freimer, Nelson B.
  • Friedl, Marion
  • Friedman, Joseph I.
  • Fromer, Menachem
  • Genovese, Giulio
  • Georgieva, Lyudmila
  • Giegling, Ina
  • Giusti-Rodríguez, Paola
  • Godard, Stephanie
  • Goldstein, Jacqueline I.
  • Golimbet, Vera
  • Gopal, Srihari
  • Gratten, Jacob
  • De Haan, Lieuwe
  • Hammer, Christian
  • Hamshere, Marian L.
  • Hansen, Mark
  • Hansen, Thomas
  • Haroutunian, Vahram
  • Hartmann, Annette M.
  • Henskens, Frans A.
  • Herms, Stefan
  • Hirschhorn, Joel N.
  • Hoffmann, Per
  • Hofman, Andrea
  • Hollegaard, Mads V.
  • Hougaard, David M.
  • Ikeda, Masashi
  • Joa, Inge
  • Julià, Antonio
  • Kahn, René S.
  • Kalaydjieva, Luba
  • Karachanak-Yankova, Sena
  • Karjalainen, Juha
  • Kavanagh, David
  • Keller, Matthew C.
  • Kennedy, James L.
  • Khrunin, Andrey
  • Kim, Yunjung
  • Klovins, Janis
  • Knowles, James A.
  • Konte, Bettina
  • Kucinskas, Vaidutis
  • Ausrele Kucinskiene, Zita
  • Kuzelova-Ptackova, Hana
  • Kähler, Anna K.
  • Laurent, Claudine
  • Lee Chee Keong, Jimmy
  • Hong Lee, S.
  • Legge, Sophie E.
  • Lerer, Bernard
  • Li, Miaoxin
  • Li, Tao
  • Liang, Kung-Yee
  • Lieberman, Jeffrey
  • Limborska, Svetlana
  • Loughland, Carmel M.
  • Lubinski, Jan
  • Lönnqvist, Jouko
  • Macek Jr, Milan
  • Magnusson, Patrik K. E.
  • Maher, Brion S.
  • Maier, Wolfgang
  • Mallet, Jacques
  • Marsal, Sara
  • Mattheisen, Manuel
  • Mattingsdal, Morten
  • Mccarley, Robert W.
  • Mcdonald, Colm
  • Mcintosh, Andrew M.
  • Meier, Sandra
  • Meijer, Carin J.
  • Melegh, Bela
  • Melle, Ingrid
  • Mesholam-Gately, Raquelle I.
  • Metspalu, Andres
  • Michie, Patricia T.
  • Milani, Lili
  • Milanova, Vihra
  • Mokrab, Younes
  • Morris, Derek W.
  • Mors, Ole
  • Murphy, Kieran C.
  • Murray, Robin M.
  • Myin-Germeys, Inez
  • Müller-Myhsok, Bertram
  • Nelis, Mari
  • Nenadic, Igor
  • Nertney, Deborah A.
  • Nestadt, Gerald
  • Nicodemus, Kristin K.
  • Nikitina-Zake, Liene
  • Nisenbaum, Laura
  • Nordin, Annelie
  • O’callaghan, Eadbhard
  • O’dushlaine, Colm
  • O’neill, F. Anthony
  • Oh, Sang-Yun
  • Olincy, Ann
  • Olsen, Line
  • Van Os, Jim
  • Endophenotypes International Consortium, Psychosis
  • Pantelis, Christos
  • Papadimitriou, George N.
  • Papiol, Sergi
  • Parkhomenko, Elena
  • Pato, Michele T.
  • Paunio, Tiina
  • Pejovic-Milovancevic, Milica
  • Perkins, Diana O.
  • Pietiläinen, Olli
  • Pimm, Jonathan
  • Pocklington, Andrew J.
  • Powell, John
  • Price, Alkes
  • Pulver, Ann E.
  • Purcell, Shaun M.
  • Quested, Digby
  • Rasmussen, Henrik B.
  • Reichenberg, Abraham
  • Reimers, Mark A.
  • Richards, Alexander L.
  • Roffman, Joshua L.
  • Roussos, Panos
  • Ruderfer, Douglas M.
  • Salomaa, Veikko
  • Sanders, Alan R.
  • Schall, Ulrich
  • Schubert, Christian R.
  • Schulze, Thomas G.
  • Schwab, Sibylle G.
  • Scolnick, Edward M.
  • Scott, Rodney J.
  • Seidman, Larry J.
  • Shi, Jianxin
  • Sigurdsson, Engilbert
  • Silagadze, Teimuraz
  • Silverman, Jeremy M.
  • Sim, Kang
  • Slominsky, Petr
  • Smoller, Jordan W.
  • So, Hon-Cheong
  • Spencer, Chrisc. A.
  • Stahl, Eli A.
  • Stefansson, Hreinn
  • Steinberg, Stacy
  • Stogmann, Elisabeth
  • Straub, Richard E.
  • Strengman, Eric
  • Strohmaier, Jana
  • Scott Stroup, T.
  • Subramaniam, Mythily
  • Suvisaari, Jaana
  • Svrakic, Dragan M.
  • Szatkiewicz, Jin P.
  • Söderman, Erik
  • Thirumalai, Srinivas
  • Toncheva, Draga
  • Tosato, Sarah
  • Veijola, Juha
  • Waddington, John
  • Walsh, Dermot
  • Wang, Dai
  • Wang, Qiang
  • Webb, Bradley T.
  • Weiser, Mark
  • Wildenauer, Dieter B.
  • Williams, Nigel M.
  • Williams, Stephanie
  • Witt, Stephanie H.
  • Wolen, Aaron R.
  • Wong, Emily H. M.
  • Wormley, Brandon K.
  • Simon Xi, Hualin
  • Zai, Clement C.
  • Zheng, Xuebin
  • Zimprich, Fritz
  • Wray, Naomi R.
  • Stefansson, Kari
subjects:
  • Genome-Wide Association
  • Common Variants
  • Bipolar Disorder
  • Conferring Risk
  • Disease
  • Metaanalysis
  • Mutations
  • Drugs
ispartof: Ripke, Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. A.; Stahl, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wormley, Brandon K.; Simon Xi, Hualin; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Trust Case-Control Consortium, Wellcome; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (7510),
description: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
language:
source:
identifier: DOI: 10.1038/nature13595
fulltext: fulltext_linktorsrc
url: Link


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creatorRipke, Stephan ; Neale, Benjamin M. ; Corvin, Aiden ; Walters, James T. R. ; Farh, Kai-How ; Holmans, Peter A. ; Lee, Phil ; Bulik-Sullivan, Brendan ; Collier, David A. ; Huang, Hailiang ; Pers, Tune H. ; Agartz, Ingrid ; Agerbo, Esben ; Albus, Margot ; Alexander, Madeline ; Amin, Farooq ; Bacanu, Silviu A. ; Begemann, Martin ; Belliveau Jr, Richard A. ; Bene, Judit ; Bergen, Sarah E. ; Bevilacqua, Elizabeth ; Bigdeli, Tim B. ; Black, Donald W. ; Bruggeman, Richard ; Buccola, Nancy G. ; Buckner, Randy L. ; Byerley, William ; Cahn, Wiepke ; Cai, Guiqing ; Campion, Dominique ; Cantor, Rita M. ; Carr, Vaughan J. ; Carrera, Noa ; Catts, Stanley V. ; Chambert, Kimberly D. ; Chan, Raymond C. K. ; Chen, Ronald Y. L. ; Chen, Eric Y. H. ; Cheng, Wei ; Cheung, Eric F. C. ; Ann Chong, Siow ; Robert Cloninger, C. ; Cohen, David ; Cohen, Nadine ; Cormican, Paul ; Craddock, Nick ; Crowley, James J. ; Curtis, David ; Davidson, Michael ; Davis, Kenneth L. ; Degenhardt, Franziska ; Del Favero, Jurgen ; Demontis, Ditte ; Dikeos, Dimitris ; Dinan, Timothy ; Djurovic, Srdjan ; Donohoe, Gary ; Drapeau, Elodie ; Duan, Jubao ; Dudbridge, Frank ; Durmishi, Naser ; Eichhammer, Peter ; Eriksson, Johan ; Escott-Price, Valentina ; Essioux, Laurent ; Fanous, Ayman H. ; Farrell, Martilias S. ; Frank, Josef ; Franke, Lude ; Freedman, Robert ; Freimer, Nelson B. ; Friedl, Marion ; Friedman, Joseph I. ; Fromer, Menachem ; Genovese, Giulio ; Georgieva, Lyudmila ; Giegling, Ina ; Giusti-Rodríguez, Paola ; Godard, Stephanie ; Goldstein, Jacqueline I. ; Golimbet, Vera ; Gopal, Srihari ; Gratten, Jacob ; De Haan, Lieuwe ; Hammer, Christian ; Hamshere, Marian L. ; Hansen, Mark ; Hansen, Thomas ; Haroutunian, Vahram ; Hartmann, Annette M. ; Henskens, Frans A. ; Herms, Stefan ; Hirschhorn, Joel N. ; Hoffmann, Per ; Hofman, Andrea ; Hollegaard, Mads V. ; Hougaard, David M. ; Ikeda, Masashi ; Joa, Inge ; Julià, Antonio ; Kahn, René S. ; Kalaydjieva, Luba ; Karachanak-Yankova, Sena ; Karjalainen, Juha ; Kavanagh, David ; Keller, Matthew C. ; Kennedy, James L. ; Khrunin, Andrey ; Kim, Yunjung ; Klovins, Janis ; Knowles, James A. ; Konte, Bettina ; Kucinskas, Vaidutis ; Ausrele Kucinskiene, Zita ; Kuzelova-Ptackova, Hana ; Kähler, Anna K. ; Laurent, Claudine ; Lee Chee Keong, Jimmy ; Hong Lee, S. ; Legge, Sophie E. ; Lerer, Bernard ; Li, Miaoxin ; Li, Tao ; Liang, Kung-Yee ; Lieberman, Jeffrey ; Limborska, Svetlana ; Loughland, Carmel M. ; Lubinski, Jan ; Lönnqvist, Jouko ; Macek Jr, Milan ; Magnusson, Patrik K. E. ; Maher, Brion S. ; Maier, Wolfgang ; Mallet, Jacques ; Marsal, Sara ; Mattheisen, Manuel ; Mattingsdal, Morten ; Mccarley, Robert W. ; Mcdonald, Colm ; Mcintosh, Andrew M. ; Meier, Sandra ; Meijer, Carin J. ; Melegh, Bela ; Melle, Ingrid ; Mesholam-Gately, Raquelle I. ; Metspalu, Andres ; Michie, Patricia T. ; Milani, Lili ; Milanova, Vihra ; Mokrab, Younes ; Morris, Derek W. ; Mors, Ole ; Murphy, Kieran C. ; Murray, Robin M. ; Myin-Germeys, Inez ; Müller-Myhsok, Bertram ; Nelis, Mari ; Nenadic, Igor ; Nertney, Deborah A. ; Nestadt, Gerald ; Nicodemus, Kristin K. ; Nikitina-Zake, Liene ; Nisenbaum, Laura ; Nordin, Annelie ; O’callaghan, Eadbhard ; O’dushlaine, Colm ; O’neill, F. Anthony ; Oh, Sang-Yun ; Olincy, Ann ; Olsen, Line ; Van Os, Jim ; Endophenotypes International Consortium, Psychosis ; Pantelis, Christos ; Papadimitriou, George N. ; Papiol, Sergi ; Parkhomenko, Elena ; Pato, Michele T. ; Paunio, Tiina ; Pejovic-Milovancevic, Milica ; Perkins, Diana O. ; Pietiläinen, Olli ; Pimm, Jonathan ; Pocklington, Andrew J. ; Powell, John ; Price, Alkes ; Pulver, Ann E. ; Purcell, Shaun M. ; Quested, Digby ; Rasmussen, Henrik B. ; Reichenberg, Abraham ; Reimers, Mark A. ; Richards, Alexander L. ; Roffman, Joshua L. ; Roussos, Panos ; Ruderfer, Douglas M. ; Salomaa, Veikko ; Sanders, Alan R. ; Schall, Ulrich ; Schubert, Christian R. ; Schulze, Thomas G. ; Schwab, Sibylle G. ; Scolnick, Edward M. ; Scott, Rodney J. ; Seidman, Larry J. ; Shi, Jianxin ; Sigurdsson, Engilbert ; Silagadze, Teimuraz ; Silverman, Jeremy M. ; Sim, Kang ; Slominsky, Petr ; Smoller, Jordan W. ; So, Hon-Cheong ; Spencer, Chrisc. A. ; Stahl, Eli A. ; Stefansson, Hreinn ; Steinberg, Stacy ; Stogmann, Elisabeth ; Straub, Richard E. ; Strengman, Eric ; Strohmaier, Jana ; Scott Stroup, T. ; Subramaniam, Mythily ; Suvisaari, Jaana ; Svrakic, Dragan M. ; Szatkiewicz, Jin P. ; Söderman, Erik ; Thirumalai, Srinivas ; Toncheva, Draga ; Tosato, Sarah ; Veijola, Juha ; Waddington, John ; Walsh, Dermot ; Wang, Dai ; Wang, Qiang ; Webb, Bradley T. ; Weiser, Mark ; Wildenauer, Dieter B. ; Williams, Nigel M. ; Williams, Stephanie ; Witt, Stephanie H. ; Wolen, Aaron R. ; Wong, Emily H. M. ; Wormley, Brandon K. ; Simon Xi, Hualin ; Zai, Clement C. ; Zheng, Xuebin ; Zimprich, Fritz ; Wray, Naomi R. ; Stefansson, Kari
ispartofRipke, Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. 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identifier DOI: 10.1038/nature13595
subjectGenome-Wide Association ; Common Variants ; Bipolar Disorder ; Conferring Risk ; Disease ; Metaanalysis ; Mutations ; Drugs
descriptionSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
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creatorcontrib
0Ripke, Stephan
1Neale, Benjamin M.
2Corvin, Aiden
3Walters, James T. R.
4Farh, Kai-How
5Holmans, Peter A.
6Lee, Phil
7Bulik-Sullivan, Brendan
8Collier, David A.
9Huang, Hailiang
10Pers, Tune H.
11Agartz, Ingrid
12Agerbo, Esben
13Albus, Margot
14Alexander, Madeline
15Amin, Farooq
16Bacanu, Silviu A.
17Begemann, Martin
18Belliveau Jr, Richard A.
19Bene, Judit
20Bergen, Sarah E.
21Bevilacqua, Elizabeth
22Bigdeli, Tim B.
23Black, Donald W.
24Bruggeman, Richard
25Buccola, Nancy G.
26Buckner, Randy L.
27Byerley, William
28Cahn, Wiepke
29Cai, Guiqing
30Campion, Dominique
31Cantor, Rita M.
32Carr, Vaughan J.
33Carrera, Noa
34Catts, Stanley V.
35Chambert, Kimberly D.
36Chan, Raymond C. K.
37Chen, Ronald Y. L.
38Chen, Eric Y. H.
39Cheng, Wei
40Cheung, Eric F. C.
41Ann Chong, Siow
42Robert Cloninger, C.
43Cohen, David
44Cohen, Nadine
45Cormican, Paul
46Craddock, Nick
47Crowley, James J.
48Curtis, David
49Davidson, Michael
50Davis, Kenneth L.
51Degenhardt, Franziska
52Del Favero, Jurgen
53Demontis, Ditte
54Dikeos, Dimitris
55Dinan, Timothy
56Djurovic, Srdjan
57Donohoe, Gary
58Drapeau, Elodie
59Duan, Jubao
60Dudbridge, Frank
61Durmishi, Naser
62Eichhammer, Peter
63Eriksson, Johan
64Escott-Price, Valentina
65Essioux, Laurent
66Fanous, Ayman H.
67Farrell, Martilias S.
68Frank, Josef
69Franke, Lude
70Freedman, Robert
71Freimer, Nelson B.
72Friedl, Marion
73Friedman, Joseph I.
74Fromer, Menachem
75Genovese, Giulio
76Georgieva, Lyudmila
77Giegling, Ina
78Giusti-Rodríguez, Paola
79Godard, Stephanie
80Goldstein, Jacqueline I.
81Golimbet, Vera
82Gopal, Srihari
83Gratten, Jacob
84De Haan, Lieuwe
85Hammer, Christian
86Hamshere, Marian L.
87Hansen, Mark
88Hansen, Thomas
89Haroutunian, Vahram
90Hartmann, Annette M.
91Henskens, Frans A.
92Herms, Stefan
93Hirschhorn, Joel N.
94Hoffmann, Per
95Hofman, Andrea
96Hollegaard, Mads V.
97Hougaard, David M.
98Ikeda, Masashi
99Joa, Inge
100...
titleBiological insights from 108 schizophrenia-associated genetic loci
descriptionSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
subject
0Genome-Wide Association
1Common Variants
2Bipolar Disorder
3Conferring Risk
4Disease
5Metaanalysis
6Mutations
7Drugs
general
0Springer Nature
1Ripke, Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. 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R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (7510),
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addtitleRipke, Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. A.; Stahl, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wormley, Brandon K.; Simon Xi, Hualin; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Trust Case-Control Consortium, Wellcome; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (7510),
searchscopearan
scopearan
lsr30VSR-Enriched:[orcidid, vol, issn, pqid, galeid, issue, eissn, pages]
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titleBiological insights from 108 schizophrenia-associated genetic loci
authorRipke, Stephan ; Neale, Benjamin M. ; Corvin, Aiden ; Walters, James T. R. ; Farh, Kai-How ; Holmans, Peter A. ; Lee, Phil ; Bulik-Sullivan, Brendan ; Collier, David A. ; Huang, Hailiang ; Pers, Tune H. ; Agartz, Ingrid ; Agerbo, Esben ; Albus, Margot ; Alexander, Madeline ; Amin, Farooq ; Bacanu, Silviu A. ; Begemann, Martin ; Belliveau Jr, Richard A. ; Bene, Judit ; Bergen, Sarah E. ; Bevilacqua, Elizabeth ; Bigdeli, Tim B. ; Black, Donald W. ; Bruggeman, Richard ; Buccola, Nancy G. ; Buckner, Randy L. ; Byerley, William ; Cahn, Wiepke ; Cai, Guiqing ; Campion, Dominique ; Cantor, Rita M. ; Carr, Vaughan J. ; Carrera, Noa ; Catts, Stanley V. ; Chambert, Kimberly D. ; Chan, Raymond C. K. ; Chen, Ronald Y. L. ; Chen, Eric Y. H. ; Cheng, Wei ; Cheung, Eric F. C. ; Ann Chong, Siow ; Robert Cloninger, C. ; Cohen, David ; Cohen, Nadine ; Cormican, Paul ; Craddock, Nick ; Crowley, James J. ; Curtis, David ; Davidson, Michael ; Davis, Kenneth L. ; Degenhardt, Franziska ; Del Favero, Jurgen ; Demontis, Ditte ; Dikeos, Dimitris ; Dinan, Timothy ; Djurovic, Srdjan ; Donohoe, Gary ; Drapeau, Elodie ; Duan, Jubao ; Dudbridge, Frank ; Durmishi, Naser ; Eichhammer, Peter ; Eriksson, Johan ; Escott-Price, Valentina ; Essioux, Laurent ; Fanous, Ayman H. ; Farrell, Martilias S. ; Frank, Josef ; Franke, Lude ; Freedman, Robert ; Freimer, Nelson B. ; Friedl, Marion ; Friedman, Joseph I. ; Fromer, Menachem ; Genovese, Giulio ; Georgieva, Lyudmila ; Giegling, Ina ; Giusti-Rodríguez, Paola ; Godard, Stephanie ; Goldstein, Jacqueline I. ; Golimbet, Vera ; Gopal, Srihari ; Gratten, Jacob ; De Haan, Lieuwe ; Hammer, Christian ; Hamshere, Marian L. ; Hansen, Mark ; Hansen, Thomas ; Haroutunian, Vahram ; Hartmann, Annette M. ; Henskens, Frans A. ; Herms, Stefan ; Hirschhorn, Joel N. ; Hoffmann, Per ; Hofman, Andrea ; Hollegaard, Mads V. ; Hougaard, David M. ; Ikeda, Masashi ; Joa, Inge ; Julià, Antonio ; Kahn, René S. ; Kalaydjieva, Luba ; Karachanak-Yankova, Sena ; Karjalainen, Juha ; Kavanagh, David ; Keller, Matthew C. ; Kennedy, James L. ; Khrunin, Andrey ; Kim, Yunjung ; Klovins, Janis ; Knowles, James A. ; Konte, Bettina ; Kucinskas, Vaidutis ; Ausrele Kucinskiene, Zita ; Kuzelova-Ptackova, Hana ; Kähler, Anna K. ; Laurent, Claudine ; Lee Chee Keong, Jimmy ; Hong Lee, S. ; Legge, Sophie E. ; Lerer, Bernard ; Li, Miaoxin ; Li, Tao ; Liang, Kung-Yee ; Lieberman, Jeffrey ; Limborska, Svetlana ; Loughland, Carmel M. ; Lubinski, Jan ; Lönnqvist, Jouko ; Macek Jr, Milan ; Magnusson, Patrik K. E. ; Maher, Brion S. ; Maier, Wolfgang ; Mallet, Jacques ; Marsal, Sara ; Mattheisen, Manuel ; Mattingsdal, Morten ; Mccarley, Robert W. ; Mcdonald, Colm ; Mcintosh, Andrew M. ; Meier, Sandra ; Meijer, Carin J. ; Melegh, Bela ; Melle, Ingrid ; Mesholam-Gately, Raquelle I. ; Metspalu, Andres ; Michie, Patricia T. ; Milani, Lili ; Milanova, Vihra ; Mokrab, Younes ; Morris, Derek W. ; Mors, Ole ; Murphy, Kieran C. ; Murray, Robin M. ; Myin-Germeys, Inez ; Müller-Myhsok, Bertram ; Nelis, Mari ; Nenadic, Igor ; Nertney, Deborah A. ; Nestadt, Gerald ; Nicodemus, Kristin K. ; Nikitina-Zake, Liene ; Nisenbaum, Laura ; Nordin, Annelie ; O’callaghan, Eadbhard ; O’dushlaine, Colm ; O’neill, F. Anthony ; Oh, Sang-Yun ; Olincy, Ann ; Olsen, Line ; Van Os, Jim ; Endophenotypes International Consortium, Psychosis ; Pantelis, Christos ; Papadimitriou, George N. ; Papiol, Sergi ; Parkhomenko, Elena ; Pato, Michele T. ; Paunio, Tiina ; Pejovic-Milovancevic, Milica ; Perkins, Diana O. ; Pietiläinen, Olli ; Pimm, Jonathan ; Pocklington, Andrew J. ; Powell, John ; Price, Alkes ; Pulver, Ann E. ; Purcell, Shaun M. ; Quested, Digby ; Rasmussen, Henrik B. ; Reichenberg, Abraham ; Reimers, Mark A. ; Richards, Alexander L. ; Roffman, Joshua L. ; Roussos, Panos ; Ruderfer, Douglas M. ; Salomaa, Veikko ; Sanders, Alan R. ; Schall, Ulrich ; Schubert, Christian R. ; Schulze, Thomas G. ; Schwab, Sibylle G. ; Scolnick, Edward M. ; Scott, Rodney J. ; Seidman, Larry J. ; Shi, Jianxin ; Sigurdsson, Engilbert ; Silagadze, Teimuraz ; Silverman, Jeremy M. ; Sim, Kang ; Slominsky, Petr ; Smoller, Jordan W. ; So, Hon-Cheong ; Spencer, Chrisc. A. ; Stahl, Eli A. ; Stefansson, Hreinn ; Steinberg, Stacy ; Stogmann, Elisabeth ; Straub, Richard E. ; Strengman, Eric ; Strohmaier, Jana ; Scott Stroup, T. ; Subramaniam, Mythily ; Suvisaari, Jaana ; Svrakic, Dragan M. ; Szatkiewicz, Jin P. ; Söderman, Erik ; Thirumalai, Srinivas ; Toncheva, Draga ; Tosato, Sarah ; Veijola, Juha ; Waddington, John ; Walsh, Dermot ; Wang, Dai ; Wang, Qiang ; Webb, Bradley T. ; Weiser, Mark ; Wildenauer, Dieter B. ; Williams, Nigel M. ; Williams, Stephanie ; Witt, Stephanie H. ; Wolen, Aaron R. ; Wong, Emily H. M. ; Wormley, Brandon K. ; Simon Xi, Hualin ; Zai, Clement C. ; Zheng, Xuebin ; Zimprich, Fritz ; Wray, Naomi R. ; Stefansson, Kari
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0Genome-Wide Association
1Common Variants
2Bipolar Disorder
3Conferring Risk
4Disease
5Metaanalysis
6Mutations
7Drugs
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2Corvin, Aiden
3Walters, James T. R.
4Farh, Kai-How
5Holmans, Peter A.
6Lee, Phil
7Bulik-Sullivan, Brendan
8Collier, David A.
9Huang, Hailiang
10Pers, Tune H.
11Agartz, Ingrid
12Agerbo, Esben
13Albus, Margot
14Alexander, Madeline
15Amin, Farooq
16Bacanu, Silviu A.
17Begemann, Martin
18Belliveau Jr, Richard A.
19Bene, Judit
20Bergen, Sarah E.
21Bevilacqua, Elizabeth
22Bigdeli, Tim B.
23Black, Donald W.
24Bruggeman, Richard
25Buccola, Nancy G.
26Buckner, Randy L.
27Byerley, William
28Cahn, Wiepke
29Cai, Guiqing
30Campion, Dominique
31Cantor, Rita M.
32Carr, Vaughan J.
33Carrera, Noa
34Catts, Stanley V.
35Chambert, Kimberly D.
36Chan, Raymond C. K.
37Chen, Ronald Y. L.
38Chen, Eric Y. H.
39Cheng, Wei
40Cheung, Eric F. C.
41Ann Chong, Siow
42Robert Cloninger, C.
43Cohen, David
44Cohen, Nadine
45Cormican, Paul
46Craddock, Nick
47Crowley, James J.
48Curtis, David
49Davidson, Michael
50Davis, Kenneth L.
51Degenhardt, Franziska
52Del Favero, Jurgen
53Demontis, Ditte
54Dikeos, Dimitris
55Dinan, Timothy
56Djurovic, Srdjan
57Donohoe, Gary
58Drapeau, Elodie
59Duan, Jubao
60Dudbridge, Frank
61Durmishi, Naser
62Eichhammer, Peter
63Eriksson, Johan
64Escott-Price, Valentina
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66Fanous, Ayman H.
67Farrell, Martilias S.
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74Fromer, Menachem
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92Herms, Stefan
93Hirschhorn, Joel N.
94Hoffmann, Per
95Hofman, Andrea
96Hollegaard, Mads V.
97Hougaard, David M.
98Ikeda, Masashi
99Joa, Inge
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12Esben
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15Farooq
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18Richard A.
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21Elizabeth
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23Donald W.
24Richard
25Nancy G.
26Randy L.
27William
28Wiepke
29Guiqing
30Dominique
31Rita M.
32Vaughan J.
33Noa
34Stanley V.
35Kimberly D.
36Raymond C. K.
37Ronald Y. L.
38Eric Y. H.
39Wei
40Eric F. C.
41Siow
42C.
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45Paul
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49Kenneth L.
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52Ditte
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70Nelson B.
71Marion
72Joseph I.
73Menachem
74Giulio
75Lyudmila
76Ina
77Paola
78Stephanie
79Jacqueline I.
80Vera
81Srihari
82Jacob
83Lieuwe
84Christian
85Marian L.
86Mark
87Thomas
88Vahram
89Annette M.
90Frans A.
91Stefan
92Joel N.
93Per
94Andrea
95Mads V.
96David M.
97Masashi
98Inge
99Antonio
100...
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0Ripke, Stephan
1Neale, Benjamin M.
2Corvin, Aiden
3Walters, James T. R.
4Farh, Kai-How
5Holmans, Peter A.
6Lee, Phil
7Bulik-Sullivan, Brendan
8Collier, David A.
9Huang, Hailiang
10Pers, Tune H.
11Agartz, Ingrid
12Agerbo, Esben
13Albus, Margot
14Alexander, Madeline
15Amin, Farooq
16Bacanu, Silviu A.
17Begemann, Martin
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41Ann Chong, Siow
42Robert Cloninger, C.
43Cohen, David
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45Cormican, Paul
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47Crowley, James J.
48Curtis, David
49Davidson, Michael
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51Degenhardt, Franziska
52Del Favero, Jurgen
53Demontis, Ditte
54Dikeos, Dimitris
55Dinan, Timothy
56Djurovic, Srdjan
57Donohoe, Gary
58Drapeau, Elodie
59Duan, Jubao
60Dudbridge, Frank
61Durmishi, Naser
62Eichhammer, Peter
63Eriksson, Johan
64Escott-Price, Valentina
65Essioux, Laurent
66Fanous, Ayman H.
67Farrell, Martilias S.
68Frank, Josef
69Franke, Lude
70Freedman, Robert
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72Friedl, Marion
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76Georgieva, Lyudmila
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78Giusti-Rodríguez, Paola
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81Golimbet, Vera
82Gopal, Srihari
83Gratten, Jacob
84De Haan, Lieuwe
85Hammer, Christian
86Hamshere, Marian L.
87Hansen, Mark
88Hansen, Thomas
89Haroutunian, Vahram
90Hartmann, Annette M.
91Henskens, Frans A.
92Herms, Stefan
93Hirschhorn, Joel N.
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98Ikeda, Masashi
99Joa, Inge
100...
atitleBiological insights from 108 schizophrenia-associated genetic loci
risdate20140722
genrearticle
ristypeJOUR
abstractSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
pubSpringer Nature
doi10.1038/nature13595
urlhttp://hdl.handle.net/10379/13659
formatarticle
orcidid0000-0002-8907-5804
volume511
issue7510
pages421-427
issn00280836
eissn14764687
oafree_for_read
date2014-07-22
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