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Impact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P

The effects of the challenge dose and major histocompatibility complex (MHC) class IB alleles were analyzed in 112 Mauritian cynomolgus monkeys vaccinated (n = 67) or not vaccinated (n = 45) with Tat and challenged with simian/human immunodeficiency virus (SHIV) 89.6P(cy243.) In the controls, the ch... Full description

Journal Title: The Journal of Virology 2010, Vol. 84(17), p.8953
Main Author: Cafaro, Aurelio
Other Authors: Bellino, Stefania , Titti, Fausto , Maggiorella, Maria Teresa , Sernicola, Leonardo , Wiseman, Roger W. , Venzon, David , Karl, Julie A. , O'Connor, David , Monini, Paolo , Robert-Guroff, Marjorie , Ensoli, Barbara
Format: Electronic Article Electronic Article
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ID: ISSN: 0022-538X ; PMID: 20554774
Link: http://jvi.asm.org/cgi/content/abstract/84/17/8953
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recordid: asm20554774
title: Impact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P
format: Article
creator:
  • Cafaro, Aurelio
  • Bellino, Stefania
  • Titti, Fausto
  • Maggiorella, Maria Teresa
  • Sernicola, Leonardo
  • Wiseman, Roger W.
  • Venzon, David
  • Karl, Julie A.
  • O'Connor, David
  • Monini, Paolo
  • Robert-Guroff, Marjorie
  • Ensoli, Barbara
subjects:
  • Biology
ispartof: The Journal of Virology, 2010, Vol. 84(17), p.8953
description: The effects of the challenge dose and major histocompatibility complex (MHC) class IB alleles were analyzed in 112 Mauritian cynomolgus monkeys vaccinated (n = 67) or not vaccinated (n = 45) with Tat and challenged with simian/human immunodeficiency virus (SHIV) 89.6P(cy243.) In the controls, the challenge dose (10 to 20 50% monkey infectious doses [MID(50)]) or MHC did not affect susceptibility to infection, peak viral load, or acute CD4 T-cell loss, whereas in the chronic phase of infection, the H1 haplotype correlated with a high viral load (P = 0.0280) and CD4 loss (P = 0.0343). Vaccination reduced the rate of infection acquisition at 10 MID(50) (P < 0.0001), and contained acute CD4 loss at 15 MID(50) (P = 0.0099). Haplotypes H2 and H6 were correlated with increased susceptibility (P = 0.0199) and resistance (P = 0.0087) to infection, respectively. Vaccination also contained CD4 depletion (P = 0.0391) during chronic infection, independently of the challenge dose or haplotype.
language:
source:
identifier: ISSN: 0022-538X ; PMID: 20554774
fulltext: fulltext
issn:
  • 0022-538X
  • 0022538X
url: Link


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titleImpact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P
creatorCafaro, Aurelio ; Bellino, Stefania ; Titti, Fausto ; Maggiorella, Maria Teresa ; Sernicola, Leonardo ; Wiseman, Roger W. ; Venzon, David ; Karl, Julie A. ; O'Connor, David ; Monini, Paolo ; Robert-Guroff, Marjorie ; Ensoli, Barbara
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identifierISSN: 0022-538X ; PMID: 20554774
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descriptionThe effects of the challenge dose and major histocompatibility complex (MHC) class IB alleles were analyzed in 112 Mauritian cynomolgus monkeys vaccinated (n = 67) or not vaccinated (n = 45) with Tat and challenged with simian/human immunodeficiency virus (SHIV) 89.6P(cy243.) In the controls, the challenge dose (10 to 20 50% monkey infectious doses [MID(50)]) or MHC did not affect susceptibility to infection, peak viral load, or acute CD4 T-cell loss, whereas in the chronic phase of infection, the H1 haplotype correlated with a high viral load (P = 0.0280) and CD4 loss (P = 0.0343). Vaccination reduced the rate of infection acquisition at 10 MID(50) (P < 0.0001), and contained acute CD4 loss at 15 MID(50) (P = 0.0099). Haplotypes H2 and H6 were correlated with increased susceptibility (P = 0.0199) and resistance (P = 0.0087) to infection, respectively. Vaccination also contained CD4 depletion (P = 0.0391) during chronic infection, independently of the challenge dose or haplotype.
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titleImpact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P
authorCafaro, Aurelio ; Bellino, Stefania ; Titti, Fausto ; Maggiorella, Maria Teresa ; Sernicola, Leonardo ; Wiseman, Roger W. ; Venzon, David ; Karl, Julie A. ; O'Connor, David ; Monini, Paolo ; Robert-Guroff, Marjorie ; Ensoli, Barbara
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