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Simian Immunodeficiency Virus SIVmac239{Delta}nef Vaccination Elicits Different Tat28-35SL8-Specific CD8+ T-Cell Clonotypes Compared to a DNA Prime/Adenovirus Type 5 Boost Regimen in Rhesus Macaques

Different human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) vaccine vectors expressing the same viral antigens can elicit disparate T-cell responses. Within this spectrum, replicating variable vaccines, like SIVmac239Δnef, appear to generate particularly efficacious CD8(+) T-cel... Full description

Journal Title: The Journal of Virology 2011, Vol. 85(7), p.3683
Main Author: Burwitz, Benjamin J.
Other Authors: Ende, Zachary , Sudolcan, Benjamin , Reynolds, Matthew R. , Greene, Justin M. , Bimber, Benjamin N. , Almeida, Jorge R. , Kurniawan, Monica , Venturi, Vanessa , Gostick, Emma , Wiseman, Roger W. , Douek, Daniel C. , Price, David A. , O'Connor, David H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-538X ; PMID: 21270159
Link: http://jvi.asm.org/cgi/content/abstract/85/7/3683
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recordid: asm21270159
title: Simian Immunodeficiency Virus SIVmac239{Delta}nef Vaccination Elicits Different Tat28-35SL8-Specific CD8+ T-Cell Clonotypes Compared to a DNA Prime/Adenovirus Type 5 Boost Regimen in Rhesus Macaques
format: Article
creator:
  • Burwitz, Benjamin J.
  • Ende, Zachary
  • Sudolcan, Benjamin
  • Reynolds, Matthew R.
  • Greene, Justin M.
  • Bimber, Benjamin N.
  • Almeida, Jorge R.
  • Kurniawan, Monica
  • Venturi, Vanessa
  • Gostick, Emma
  • Wiseman, Roger W.
  • Douek, Daniel C.
  • Price, David A.
  • O'Connor, David H
subjects:
  • Biology
ispartof: The Journal of Virology, 2011, Vol. 85(7), p.3683
description: Different human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) vaccine vectors expressing the same viral antigens can elicit disparate T-cell responses. Within this spectrum, replicating variable vaccines, like SIVmac239Δnef, appear to generate particularly efficacious CD8(+) T-cell responses. Here, we sequenced T-cell receptor β-chain (TRB) gene rearrangements from immunodominant Mamu-A 01-restricted Tat(28-35)SL8-specific CD8(+) T-cell populations together with the corresponding viral epitope in four rhesus macaques during acute SIVmac239Δnef infection. Ultradeep pyrosequencing showed that viral variants arose with identical kinetics in SIVmac239Δnef and pathogenic SIVmac239 infection. Furthermore, distinct Tat(28-35)SL8-specific T-cell receptor (TCR) repertoires were elicited by SIVmac239Δnef compared to those observed following a DNA/Ad5 prime-boost regimen, likely reflecting differences in antigen sequence stability.
language: eng
source:
identifier: ISSN: 0022-538X ; PMID: 21270159
fulltext: fulltext
issn:
  • 0022-538X
  • 0022538X
url: Link


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titleSimian Immunodeficiency Virus SIVmac239{Delta}nef Vaccination Elicits Different Tat28-35SL8-Specific CD8+ T-Cell Clonotypes Compared to a DNA Prime/Adenovirus Type 5 Boost Regimen in Rhesus Macaques
creatorBurwitz, Benjamin J. ; Ende, Zachary ; Sudolcan, Benjamin ; Reynolds, Matthew R. ; Greene, Justin M. ; Bimber, Benjamin N. ; Almeida, Jorge R. ; Kurniawan, Monica ; Venturi, Vanessa ; Gostick, Emma ; Wiseman, Roger W. ; Douek, Daniel C. ; Price, David A. ; O'Connor, David H
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descriptionDifferent human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) vaccine vectors expressing the same viral antigens can elicit disparate T-cell responses. Within this spectrum, replicating variable vaccines, like SIVmac239Δnef, appear to generate particularly efficacious CD8(+) T-cell responses. Here, we sequenced T-cell receptor β-chain (TRB) gene rearrangements from immunodominant Mamu-A 01-restricted Tat(28-35)SL8-specific CD8(+) T-cell populations together with the corresponding viral epitope in four rhesus macaques during acute SIVmac239Δnef infection. Ultradeep pyrosequencing showed that viral variants arose with identical kinetics in SIVmac239Δnef and pathogenic SIVmac239 infection. Furthermore, distinct Tat(28-35)SL8-specific T-cell receptor (TCR) repertoires were elicited by SIVmac239Δnef compared to those observed following a DNA/Ad5 prime-boost regimen, likely reflecting differences in antigen sequence stability.
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titleSimian Immunodeficiency Virus SIVmac239{Delta}nef Vaccination Elicits Different Tat28-35SL8-Specific CD8+ T-Cell Clonotypes Compared to a DNA Prime/Adenovirus Type 5 Boost Regimen in Rhesus Macaques
authorBurwitz, Benjamin J. ; Ende, Zachary ; Sudolcan, Benjamin ; Reynolds, Matthew R. ; Greene, Justin M. ; Bimber, Benjamin N. ; Almeida, Jorge R. ; Kurniawan, Monica ; Venturi, Vanessa ; Gostick, Emma ; Wiseman, Roger W. ; Douek, Daniel C. ; Price, David A. ; O'Connor, David H
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