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Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascula... Full description

Journal Title: https://doi.org/10.1161/JAHA.115.002543
Main Author: Sala Vila, Aleix
Other Authors: Guasch - Ferré, Marta , Hu, Frank B. , Sánchez - Tainta, A. , Bulló, Mònica , Serra - Mir, Mercè , López Sabater, María Del Carmen , Sorlí, José V. , Arós, Fernando , Fiol Sala, Miguel , Muñoz, Miguel Ángel , Serra Majem, Lluís , Martínez, Alfredo , Corella Piquer, Dolores , Fitó Colomer, Montserrat , Salas Salvadó, Jordi , Martínez - González, Miguel Ángel , Estruch Riba, Ramon , Ros Rahola, Emilio , Vinyoles, Ernest , Predimed Investigators
Format: Electronic Article Electronic Article
Language: English
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Quelle: Universitat de Barcelona
ID: ISSN: 2047-9980
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recordid: barcelona2445/106297
title: Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
format: Article
creator:
  • Sala Vila, Aleix
  • Guasch - Ferré, Marta
  • Hu, Frank B.
  • Sánchez - Tainta, A.
  • Bulló, Mònica
  • Serra - Mir, Mercè
  • López Sabater, María Del Carmen
  • Sorlí, José V.
  • Arós, Fernando
  • Fiol Sala, Miguel
  • Muñoz, Miguel Ángel
  • Serra Majem, Lluís
  • Martínez, Alfredo
  • Corella Piquer, Dolores
  • Fitó Colomer, Montserrat
  • Salas Salvadó, Jordi
  • Martínez - González, Miguel Ángel
  • Estruch Riba, Ramon
  • Ros Rahola, Emilio
  • Vinyoles, Ernest
  • Predimed Investigators
subjects:
  • Àcids Grassos En La Nutrició
  • Factors De Risc En Les Malalties
  • Hàbits Alimentaris
  • Dieta
  • Sistema Cardiovascular
  • Cuina Mediterrània
  • Fatty Acids In Human Nutrition
  • Risk Factors In Diseases
  • Food Habits
  • Diet
  • Cardiovascular System
  • Mediterranean Cooking
ispartof: https://doi.org/10.1161/JAHA.115.002543
description: Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all‐cause mortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all‐cause mortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids.
language: eng
source: Universitat de Barcelona
identifier: ISSN: 2047-9980
fulltext: fulltext_linktorsrc
issn:
  • 20479980
  • 2047-9980
url: Link


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titleDietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
creatorSala Vila, Aleix ; Guasch - Ferré, Marta ; Hu, Frank B. ; Sánchez - Tainta, A. ; Bulló, Mònica ; Serra - Mir, Mercè ; López Sabater, María Del Carmen ; Sorlí, José V. ; Arós, Fernando ; Fiol Sala, Miguel ; Muñoz, Miguel Ángel ; Serra Majem, Lluís ; Martínez, Alfredo ; Corella Piquer, Dolores ; Fitó Colomer, Montserrat ; Salas Salvadó, Jordi ; Martínez - González, Miguel Ángel ; Estruch Riba, Ramon ; Ros Rahola, Emilio ; Vinyoles, Ernest ; Predimed Investigators
ispartofhttps://doi.org/10.1161/JAHA.115.002543
identifier ISSN: 2047-9980
subjectÀcids Grassos En La Nutrició ; Factors De Risc En Les Malalties ; Hàbits Alimentaris ; Dieta ; Sistema Cardiovascular ; Cuina Mediterrània ; Fatty Acids In Human Nutrition ; Risk Factors In Diseases ; Food Habits ; Diet ; Cardiovascular System ; Mediterranean Cooking
descriptionBackground Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all‐cause mortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all‐cause mortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids.
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12Martínez, Alfredo
13Corella Piquer, Dolores
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15Salas Salvadó, Jordi
16Martínez - González, Miguel Ángel
17Estruch Riba, Ramon
18Ros Rahola, Emilio
19Vinyoles, Ernest
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titleDietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
descriptionBackground Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all‐cause mortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all‐cause mortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids.
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1Factors De Risc En Les Malalties
2Hàbits Alimentaris
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4Sistema Cardiovascular
5Cuina Mediterrània
6Fatty Acids In Human Nutrition
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titleDietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
authorSala Vila, Aleix ; Guasch - Ferré, Marta ; Hu, Frank B. ; Sánchez - Tainta, A. ; Bulló, Mònica ; Serra - Mir, Mercè ; López Sabater, María Del Carmen ; Sorlí, José V. ; Arós, Fernando ; Fiol Sala, Miguel ; Muñoz, Miguel Ángel ; Serra Majem, Lluís ; Martínez, Alfredo ; Corella Piquer, Dolores ; Fitó Colomer, Montserrat ; Salas Salvadó, Jordi ; Martínez - González, Miguel Ángel ; Estruch Riba, Ramon ; Ros Rahola, Emilio ; Vinyoles, Ernest ; Predimed Investigators
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1Factors De Risc En Les Malalties
2Hàbits Alimentaris
3Dieta
4Sistema Cardiovascular
5Cuina Mediterrània
6Fatty Acids In Human Nutrition
7Risk Factors In Diseases
8Food Habits
9Diet
10Cardiovascular System
11Mediterranean Cooking
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6López Sabater, María Del Carmen
7Sorlí, José V.
8Arós, Fernando
9Fiol Sala, Miguel
10Muñoz, Miguel Ángel
11Serra Majem, Lluís
12Martínez, Alfredo
13Corella Piquer, Dolores
14Fitó Colomer, Montserrat
15Salas Salvadó, Jordi
16Martínez - González, Miguel Ángel
17Estruch Riba, Ramon
18Ros Rahola, Emilio
19Vinyoles, Ernest
20Predimed Investigators
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0Sala Vila, Aleix
1Guasch - Ferré, Marta
2Hu, Frank B.
3Sánchez - Tainta, A.
4Bulló, Mònica
5Serra - Mir, Mercè
6López Sabater, María Del Carmen
7Sorlí, José V.
8Arós, Fernando
9Fiol Sala, Miguel
10Muñoz, Miguel Ángel
11Serra Majem, Lluís
12Martínez, Alfredo
13Corella Piquer, Dolores
14Fitó Colomer, Montserrat
15Salas Salvadó, Jordi
16Martínez - González, Miguel Ángel
17Estruch Riba, Ramon
18Ros Rahola, Emilio
19Vinyoles, Ernest
20Predimed Investigators
atitleDietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
jtitleJournal Of The American Heart Association
risdate20150126
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pagesJournal Of The American Heart Association, 2015, vol. 5, num. 2
issn2047-9980
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abstractBackground Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all‐cause mortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all‐cause mortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids.
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