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Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.

The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty aci... Full description

Main Author: Sala Vila, Aleix
Other Authors: Harris, William S. , Cofán Pujol, Montserrat , Pérez - Heras, Ana Maria , Pintó Sala, Xavier , Lamuela Raventós, Rosa Ma. , Covas Planells, María Isabel , Estruch Riba, Ramon , Ros Rahola, Emilio
Format: Electronic Article Electronic Article
Language: English
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Quelle: Universitat de Barcelona
ID: ISSN: 0007-1145
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recordid: barcelona2445/46583
title: Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.
format: Article
creator:
  • Sala Vila, Aleix
  • Harris, William S.
  • Cofán Pujol, Montserrat
  • Pérez - Heras, Ana Maria
  • Pintó Sala, Xavier
  • Lamuela Raventós, Rosa Ma.
  • Covas Planells, María Isabel
  • Estruch Riba, Ramon
  • Ros Rahola, Emilio
subjects:
  • Dieta
  • Malalties Cardiovasculars
  • Factors De Risc En Les Malalties
  • Àcids Grassos Omega-3
  • Diet
  • Cardiovascular Diseases
  • Risk Factors In Diseases
  • Omega-3 Fatty Acids
ispartof:
description: The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
language: eng
source: Universitat de Barcelona
identifier: ISSN: 0007-1145
fulltext: fulltext_linktorsrc
issn:
  • 00071145
  • 0007-1145
url: Link


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titleDeterminants of the omega-3 index in a Mediterranean population at increased risk for CHD.
creatorSala Vila, Aleix ; Harris, William S. ; Cofán Pujol, Montserrat ; Pérez - Heras, Ana Maria ; Pintó Sala, Xavier ; Lamuela Raventós, Rosa Ma. ; Covas Planells, María Isabel ; Estruch Riba, Ramon ; Ros Rahola, Emilio
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subjectDieta ; Malalties Cardiovasculars ; Factors De Risc En Les Malalties ; Àcids Grassos Omega-3 ; Diet ; Cardiovascular Diseases ; Risk Factors In Diseases ; Omega-3 Fatty Acids
descriptionThe omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
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titleDeterminants of the omega-3 index in a Mediterranean population at increased risk for CHD.
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abstractThe omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
pubCambridge University Press
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