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Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study

Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposit... Full description

Main Author: Martínez - González, Miguel Ángel
Other Authors: García - Arellano, Ana , Toledo, Estefanía , Bes - Rastrollo, Maira , Bulló, Mònica , Corella Piquer, Dolores , Fitó Colomer, Montserrat , Ros Rahola, Emilio , Lamuela Raventós, Rosa Ma. , Rekondo, Javier , Gómez - Gracia, Enrique , Fiol Sala, Miguel , Santos - Lozano, Jose Manuel , Serra Majem, Lluís , Martínez, J. Alfredo , Eguaras, Sonia , Sáez - Tormo, Guillermo , Pintó Sala, Xavier , Estruch Riba, Ramon
Format: Electronic Article Electronic Article
Language: English
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Quelle: Universitat de Barcelona
ID: ISSN: 1932-6203
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title: Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
format: Article
creator:
  • Martínez - González, Miguel Ángel
  • García - Arellano, Ana
  • Toledo, Estefanía
  • Bes - Rastrollo, Maira
  • Bulló, Mònica
  • Corella Piquer, Dolores
  • Fitó Colomer, Montserrat
  • Ros Rahola, Emilio
  • Lamuela Raventós, Rosa Ma.
  • Rekondo, Javier
  • Gómez - Gracia, Enrique
  • Fiol Sala, Miguel
  • Santos - Lozano, Jose Manuel
  • Serra Majem, Lluís
  • Martínez, J. Alfredo
  • Eguaras, Sonia
  • Sáez - Tormo, Guillermo
  • Pintó Sala, Xavier
  • Estruch Riba, Ramon
subjects:
  • Antropometria
  • Malalties Cardiovasculars
  • Obesitat
  • Anthropometry
  • Cardiovascular Diseases
  • Obesity
ispartof:
description: Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results: After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78-1.34), 1.30 (0.97-1.75) and 1.55 (1.06-2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88-1.59), 1.02 (0.74-1.41) and 1.57 (1.19-2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions: Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.
language: eng
source: Universitat de Barcelona
identifier: ISSN: 1932-6203
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleObesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
creatorMartínez - González, Miguel Ángel ; García - Arellano, Ana ; Toledo, Estefanía ; Bes - Rastrollo, Maira ; Bulló, Mònica ; Corella Piquer, Dolores ; Fitó Colomer, Montserrat ; Ros Rahola, Emilio ; Lamuela Raventós, Rosa Ma. ; Rekondo, Javier ; Gómez - Gracia, Enrique ; Fiol Sala, Miguel ; Santos - Lozano, Jose Manuel ; Serra Majem, Lluís ; Martínez, J. Alfredo ; Eguaras, Sonia ; Sáez - Tormo, Guillermo ; Pintó Sala, Xavier ; Estruch Riba, Ramon
identifier ISSN: 1932-6203
subjectAntropometria ; Malalties Cardiovasculars ; Obesitat ; Anthropometry ; Cardiovascular Diseases ; Obesity
descriptionDifferent indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results: After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78-1.34), 1.30 (0.97-1.75) and 1.55 (1.06-2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88-1.59), 1.02 (0.74-1.41) and 1.57 (1.19-2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions: Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.
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4Bulló, Mònica
5Corella Piquer, Dolores
6Fitó Colomer, Montserrat
7Ros Rahola, Emilio
8Lamuela Raventós, Rosa Ma.
9Rekondo, Javier
10Gómez - Gracia, Enrique
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13Serra Majem, Lluís
14Martínez, J. Alfredo
15Eguaras, Sonia
16Sáez - Tormo, Guillermo
17Pintó Sala, Xavier
18Estruch Riba, Ramon
titleObesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
descriptionDifferent indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results: After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78-1.34), 1.30 (0.97-1.75) and 1.55 (1.06-2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88-1.59), 1.02 (0.74-1.41) and 1.57 (1.19-2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions: Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.
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titleObesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
authorMartínez - González, Miguel Ángel ; García - Arellano, Ana ; Toledo, Estefanía ; Bes - Rastrollo, Maira ; Bulló, Mònica ; Corella Piquer, Dolores ; Fitó Colomer, Montserrat ; Ros Rahola, Emilio ; Lamuela Raventós, Rosa Ma. ; Rekondo, Javier ; Gómez - Gracia, Enrique ; Fiol Sala, Miguel ; Santos - Lozano, Jose Manuel ; Serra Majem, Lluís ; Martínez, J. Alfredo ; Eguaras, Sonia ; Sáez - Tormo, Guillermo ; Pintó Sala, Xavier ; Estruch Riba, Ramon
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6Fitó Colomer, Montserrat
7Ros Rahola, Emilio
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12Santos - Lozano, Jose Manuel
13Serra Majem, Lluís
14Martínez, J. Alfredo
15Eguaras, Sonia
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0Martínez - González, Miguel Ángel
1García - Arellano, Ana
2Toledo, Estefanía
3Bes - Rastrollo, Maira
4Bulló, Mònica
5Corella Piquer, Dolores
6Fitó Colomer, Montserrat
7Ros Rahola, Emilio
8Lamuela Raventós, Rosa Ma.
9Rekondo, Javier
10Gómez - Gracia, Enrique
11Fiol Sala, Miguel
12Santos - Lozano, Jose Manuel
13Serra Majem, Lluís
14Martínez, J. Alfredo
15Eguaras, Sonia
16Sáez - Tormo, Guillermo
17Pintó Sala, Xavier
18Estruch Riba, Ramon
atitleObesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
jtitlePLoS One
risdate20140729
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pagesPLoS One, 2014, vol. 9, num. 7
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abstractDifferent indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results: After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78-1.34), 1.30 (0.97-1.75) and 1.55 (1.06-2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88-1.59), 1.02 (0.74-1.41) and 1.57 (1.19-2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions: Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.
pubPublic Library of Science (PLoS)
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date2014-07-29