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N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits.

Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retin... Full description

Journal Title: British Journal of Ophthalmology 1 August 1988, Vol.72(8), p.584
Main Author: Mindel, J S
Other Authors: Kharlamb, A B , Friedman, A H , Karam, J H , Stone, R D , Siegel, I M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: BMJ Publishing Group Ltd.
ID: ISSN: 0007-1161 ; E-ISSN: 1468-2079 ; DOI: 10.1136/bjo.72.8.584 ; PMID: 3415952
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recordid: bmj_journals10.1136/bjo.72.8.584
title: N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits.
format: Article
creator:
  • Mindel, J S
  • Kharlamb, A B
  • Friedman, A H
  • Karam, J H
  • Stone, R D
  • Siegel, I M
subjects:
  • Eye Diseases -- Chemically Induced
  • Phenylurea Compounds -- Toxicity
  • Rodenticides -- Toxicity
ispartof: British Journal of Ophthalmology, 1 August 1988, Vol.72(8), p.584
description: Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.
language: eng
source:
identifier: ISSN: 0007-1161 ; E-ISSN: 1468-2079 ; DOI: 10.1136/bjo.72.8.584 ; PMID: 3415952
fulltext: fulltext_linktorsrc
issn:
  • 00071161
  • 14682079
  • 0007-1161
  • 1468-2079
url: Link


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titleN-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits.
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descriptionIngestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.
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descriptionIngestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.
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abstractIngestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.
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