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Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study

Vitamin C is an important low-molecular weight antioxidant at the air-lung interface. Despite its critical role as a sacrificial antioxidant, little is known about its transport into the respiratory tract lining fluid (RTLF), or the underlying airway epithelial cells. While several vitamin C transpo... Full description

Journal Title: BMJ Open 8 April 2015, Vol.5(4)
Main Author: Larsson, Nirina
Other Authors: Rankin, Gregory D , Bicer, Elif M , Roos-Engstrand, Ester , Pourazar, Jamshid , Blomberg, Anders , Mudway, Ian S , Behndig, Annelie F
Format: Electronic Article Electronic Article
Language: English
Quelle: BMJ Journals (BMJ Publishing Group)
Publisher: British Medical Journal Publishing Group
ID: ISSN: 2044-6055 ; E-ISSN: 2044-6055 ; DOI: 10.1136/bmjopen-2014-006979 ; PMID: 25854967
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recordid: bmj_journals10.1136/bmjopen-2014-006979
title: Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study
format: Article
creator:
  • Larsson, Nirina
  • Rankin, Gregory D
  • Bicer, Elif M
  • Roos-Engstrand, Ester
  • Pourazar, Jamshid
  • Blomberg, Anders
  • Mudway, Ian S
  • Behndig, Annelie F
ispartof: BMJ Open, 8 April 2015, Vol.5(4)
description: Vitamin C is an important low-molecular weight antioxidant at the air-lung interface. Despite its critical role as a sacrificial antioxidant, little is known about its transport into the respiratory tract lining fluid (RTLF), or the underlying airway epithelial cells. While several vitamin C transporters have been identified, such as sodium-ascorbate cotransporters (SVCT1/2) and glucose transporters (GLUTs), the latter transporting dehydroascorbate, knowledge of their protein distribution within the human lung is limited, in the case of GLUTs or unknown for SVCTs.
language: eng
source: BMJ Journals (BMJ Publishing Group)
identifier: ISSN: 2044-6055 ; E-ISSN: 2044-6055 ; DOI: 10.1136/bmjopen-2014-006979 ; PMID: 25854967
fulltext: fulltext_linktorsrc
issn:
  • 20446055
  • 2044-6055
url: Link


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titleIdentification of vitamin C transporters in the human airways: a cross-sectional in vivo study
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descriptionVitamin C is an important low-molecular weight antioxidant at the air-lung interface. Despite its critical role as a sacrificial antioxidant, little is known about its transport into the respiratory tract lining fluid (RTLF), or the underlying airway epithelial cells. While several vitamin C transporters have been identified, such as sodium-ascorbate cotransporters (SVCT1/2) and glucose transporters (GLUTs), the latter transporting dehydroascorbate, knowledge of their protein distribution within the human lung is limited, in the case of GLUTs or unknown for SVCTs.
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titleIdentification of vitamin C transporters in the human airways: a cross-sectional in vivo study
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titleIdentification of vitamin C transporters in the human airways: a cross-sectional in vivo study
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abstractVitamin C is an important low-molecular weight antioxidant at the air-lung interface. Despite its critical role as a sacrificial antioxidant, little is known about its transport into the respiratory tract lining fluid (RTLF), or the underlying airway epithelial cells. While several vitamin C transporters have been identified, such as sodium-ascorbate cotransporters (SVCT1/2) and glucose transporters (GLUTs), the latter transporting dehydroascorbate, knowledge of their protein distribution within the human lung is limited, in the case of GLUTs or unknown for SVCTs.
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