schliessen

Filtern

 

Bibliotheken

Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis

The production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of... Full description

Journal Title: Gut 7 October 2018, Vol.67(10), p.1749
Main Author: Albano, Emanuele
Other Authors: Stickel, Felix
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749 ; E-ISSN: 1468-3288 ; DOI: 10.1136/gutjnl-2017-314437 ; PMID: 28687679
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: bmj_journals10.1136/gutjnl-2017-314437
title: Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
format: Article
creator:
  • Albano, Emanuele
  • Stickel, Felix
subjects:
  • Alcohol
ispartof: Gut, 7 October 2018, Vol.67(10), p.1749
description: The production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of the liver is a key feature of acute alcoholic hepatitis actively participating to parenchymal injury.2 However, during ALD progression to cirrhosis, neutrophil functions such as ROS production, bacterial phagocytosis and granule exocytosis are impaired leading to an increased susceptibility to bacterial infections of cirrhotic patients.3 Indeed, the development of bacterial peritonitis is a common complication of cirrhosis, while sepsis is a major cause of mortality in  patients with decompensated alcoholic cirrhosis being also associated with multiorgan failure and immune deficiencies.4
language: eng
source:
identifier: ISSN: 0017-5749 ; E-ISSN: 1468-3288 ; DOI: 10.1136/gutjnl-2017-314437 ; PMID: 28687679
fulltext: fulltext
issn:
  • 00175749
  • 14683288
  • 0017-5749
  • 1468-3288
url: Link


@attributes
ID736840888
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1136/gutjnl-2017-314437
sourceidbmj_journals
recordidTN_bmj_journals10.1136/gutjnl-2017-314437
sourcesystemPC
pqid2115140900
display
typearticle
titleTargeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
creatorAlbano, Emanuele ; Stickel, Felix
publisherBMJ Publishing Group Ltd and British Society of Gastroenterology
ispartofGut, 7 October 2018, Vol.67(10), p.1749
identifier
subjectAlcohol
descriptionThe production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of the liver is a key feature of acute alcoholic hepatitis actively participating to parenchymal injury.2 However, during ALD progression to cirrhosis, neutrophil functions such as ROS production, bacterial phagocytosis and granule exocytosis are impaired leading to an increased susceptibility to bacterial infections of cirrhotic patients.3 Indeed, the development of bacterial peritonitis is a common complication of cirrhosis, while sepsis is a major cause of mortality in  patients with decompensated alcoholic cirrhosis being also associated with multiorgan failure and immune deficiencies.4
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
linktorsrc$$Uhttp://gut.bmj.com/content/67/10/1749.full.pdf$$EView_this_record_in_BMJ_Journals
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Albano, Emanuele
1Stickel, Felix
titleTargeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
descriptionThe production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of the liver is a key feature of acute alcoholic hepatitis actively participating to parenchymal injury.2 However, during ALD progression to cirrhosis, neutrophil functions such as ROS production, bacterial phagocytosis and granule exocytosis are impaired leading to an increased susceptibility to bacterial infections of cirrhotic patients.3 Indeed, the development of bacterial peritonitis is a common complication of cirrhosis, while sepsis is a major cause of mortality in  patients with decompensated alcoholic cirrhosis being also associated with multiorgan failure and immune deficiencies.4
subjectAlcohol
general
0English
1BMJ Publishing Group Ltd and British Society of Gastroenterology
2BMJ Journals (BMJ Publishing Group)
310.1136/gutjnl-2017-314437
428687679
sourceidbmj_journals
recordidbmj_journals10.1136/gutjnl-2017-314437
issn
000175749
114683288
20017-5749
31468-3288
rsrctypearticle
creationdate2018
addtitleGut
searchscopebmj
scopebmj
citationpf 1749 vol 67 issue 10
startdate20181007
enddate20181007
lsr30VSR-Enriched:[pages, pqid]
sort
titleTargeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
authorAlbano, Emanuele ; Stickel, Felix
creationdate20181007
lso0120181007
facets
frbrgroupid-6344374368157787224
frbrtype5
newrecords20170712
languageeng
creationdate2018
topicAlcohol
collectionBMJ Journals (BMJ Publishing Group)
creatorcontrib
0Albano, Emanuele
1Stickel, Felix
jtitleGut
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Albano
1Stickel
aufirst
0Emanuele
1Felix
auinitE
au
0Albano, Emanuele
1Stickel, Felix
atitleTargeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
jtitleGut
stitleGut
risdate20181007
volume67
issue10
spage1749
issn
00017-5749
100175749
eissn
01468-3288
114683288
formatjournal
abstractThe production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of the liver is a key feature of acute alcoholic hepatitis actively participating to parenchymal injury.2 However, during ALD progression to cirrhosis, neutrophil functions such as ROS production, bacterial phagocytosis and granule exocytosis are impaired leading to an increased susceptibility to bacterial infections of cirrhotic patients.3 Indeed, the development of bacterial peritonitis is a common complication of cirrhosis, while sepsis is a major cause of mortality in  patients with decompensated alcoholic cirrhosis being also associated with multiorgan failure and immune deficiencies.4
pubBMJ Publishing Group Ltd and British Society of Gastroenterology
doi10.1136/gutjnl-2017-314437
urlhttp://gut.bmj.com/content/67/10/1749.full.pdf
pmid28687679
pages1749-1750
date2018-10-07