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FTY720 POST-TREATMENT PROTECTS THE CARDIAC MICROVESSELS OF DIABETES IN I/R HEART INJURY: THE PIVOTAL ROLE OF S1P1/3 MEDIATED REGULATION

Diabetes is associated with an increase in the risk of developing coronary artery disease. And the pathological role played by cardiac microvessel is significant, nonetheless, the mechanism of which remains uncertain. Sphingosine-1-phosphate receptor 1/3 (S1P1/3) are proved to make excessive contrib... Full description

Journal Title: Heart 8 October 2012, Vol.98(Suppl 2), p.E12
Main Author: Yin, Zhiyong
Other Authors: Wang, Haichang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037 ; E-ISSN: 1468-201X ; DOI: 10.1136/heartjnl-2012-302920a.28
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recordid: bmj_journals10.1136/heartjnl-2012-302920a.28
title: FTY720 POST-TREATMENT PROTECTS THE CARDIAC MICROVESSELS OF DIABETES IN I/R HEART INJURY: THE PIVOTAL ROLE OF S1P1/3 MEDIATED REGULATION
format: Article
creator:
  • Yin, Zhiyong
  • Wang, Haichang
subjects:
  • Medicine
ispartof: Heart, 8 October 2012, Vol.98(Suppl 2), p.E12
description: Diabetes is associated with an increase in the risk of developing coronary artery disease. And the pathological role played by cardiac microvessel is significant, nonetheless, the mechanism of which remains uncertain. Sphingosine-1-phosphate receptor 1/3 (S1P1/3) are proved to make excessive contribution to vascular stabilisation, suggesting their possible role in cardiac I/R injury in diabetes. FTY720 is a specific agonist for S1P1/3. However, it has not been addressed whether and how FTY720 could be developed as a therapeutic approach for cardiac microvascular I/R dysfunction in diabetes. Therefore, the purpose of present report is to provide a detailed study on the importance of S1P1/3 and its possible mechanism in cardiac I/R injury in diabetes, and the potential protection of FTY720 post-treatment.
language: eng
source:
identifier: ISSN: 1355-6037 ; E-ISSN: 1468-201X ; DOI: 10.1136/heartjnl-2012-302920a.28
fulltext: fulltext
issn:
  • 13556037
  • 1468201X
  • 1355-6037
  • 1468-201X
url: Link


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titleFTY720 POST-TREATMENT PROTECTS THE CARDIAC MICROVESSELS OF DIABETES IN I/R HEART INJURY: THE PIVOTAL ROLE OF S1P1/3 MEDIATED REGULATION
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descriptionDiabetes is associated with an increase in the risk of developing coronary artery disease. And the pathological role played by cardiac microvessel is significant, nonetheless, the mechanism of which remains uncertain. Sphingosine-1-phosphate receptor 1/3 (S1P1/3) are proved to make excessive contribution to vascular stabilisation, suggesting their possible role in cardiac I/R injury in diabetes. FTY720 is a specific agonist for S1P1/3. However, it has not been addressed whether and how FTY720 could be developed as a therapeutic approach for cardiac microvascular I/R dysfunction in diabetes. Therefore, the purpose of present report is to provide a detailed study on the importance of S1P1/3 and its possible mechanism in cardiac I/R injury in diabetes, and the potential protection of FTY720 post-treatment.
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descriptionDiabetes is associated with an increase in the risk of developing coronary artery disease. And the pathological role played by cardiac microvessel is significant, nonetheless, the mechanism of which remains uncertain. Sphingosine-1-phosphate receptor 1/3 (S1P1/3) are proved to make excessive contribution to vascular stabilisation, suggesting their possible role in cardiac I/R injury in diabetes. FTY720 is a specific agonist for S1P1/3. However, it has not been addressed whether and how FTY720 could be developed as a therapeutic approach for cardiac microvascular I/R dysfunction in diabetes. Therefore, the purpose of present report is to provide a detailed study on the importance of S1P1/3 and its possible mechanism in cardiac I/R injury in diabetes, and the potential protection of FTY720 post-treatment.
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abstractDiabetes is associated with an increase in the risk of developing coronary artery disease. And the pathological role played by cardiac microvessel is significant, nonetheless, the mechanism of which remains uncertain. Sphingosine-1-phosphate receptor 1/3 (S1P1/3) are proved to make excessive contribution to vascular stabilisation, suggesting their possible role in cardiac I/R injury in diabetes. FTY720 is a specific agonist for S1P1/3. However, it has not been addressed whether and how FTY720 could be developed as a therapeutic approach for cardiac microvascular I/R dysfunction in diabetes. Therefore, the purpose of present report is to provide a detailed study on the importance of S1P1/3 and its possible mechanism in cardiac I/R injury in diabetes, and the potential protection of FTY720 post-treatment.
pubBMJ Publishing Group Ltd and British Cardiovascular Society
doi10.1136/heartjnl-2012-302920a.28
urlhttp://heart.bmj.com/content/98/Suppl_2/E12.3.full.pdf
pagesE12.3-E13
date2012-10-08