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After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?

For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when... Full description

Journal Title: Postgraduate Medical Journal August 2012 Vol.88(1042), p.482
Main Author: Wakefield, Richard J
Other Authors: D'Agostino, Maria Antonietta , Naredo, Esperanza , Buch, Maya H , Iagnocco, Annamaria , Terslev, Lene , Ostergaard, Mikkel , Backhaus, Marina , Grassi, Walter , Dougados, Maxime , Burmester, Gerd R , Saleem, Benazir , de Miguel, Eugenio , Estrach, Cristina , Ikeda, Kei , Gutierrez, Marwin , Thompson, Robert , Balint, Peter , Emery, Paul
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: The Fellowship of Postgraduate Medicine
ID: ISSN: 0032-5473 ; E-ISSN: 1469-0756 ; DOI: 10.1136/postgradmedj-2011-201048rep ; PMID: 22822227
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recordid: bmj_journals10.1136/postgradmedj-2011-201048rep
title: After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?
format: Article
creator:
  • Wakefield, Richard J
  • D'Agostino, Maria Antonietta
  • Naredo, Esperanza
  • Buch, Maya H
  • Iagnocco, Annamaria
  • Terslev, Lene
  • Ostergaard, Mikkel
  • Backhaus, Marina
  • Grassi, Walter
  • Dougados, Maxime
  • Burmester, Gerd R
  • Saleem, Benazir
  • de Miguel, Eugenio
  • Estrach, Cristina
  • Ikeda, Kei
  • Gutierrez, Marwin
  • Thompson, Robert
  • Balint, Peter
  • Emery, Paul
subjects:
  • Antirheumatic Agents -- Therapeutic Use
  • Arthritis, Rheumatoid -- Diagnostic Imaging
  • Synovitis -- Diagnostic Imaging
ispartof: Postgraduate Medical Journal August 2012, Vol.88(1042), p.482
description: For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.
language: eng
source:
identifier: ISSN: 0032-5473 ; E-ISSN: 1469-0756 ; DOI: 10.1136/postgradmedj-2011-201048rep ; PMID: 22822227
fulltext: fulltext
issn:
  • 00325473
  • 14690756
  • 0032-5473
  • 1469-0756
url: Link


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titleAfter treat-to-target: can a targeted ultrasound initiative improve RA outcomes?
creatorWakefield, Richard J ; D'Agostino, Maria Antonietta ; Naredo, Esperanza ; Buch, Maya H ; Iagnocco, Annamaria ; Terslev, Lene ; Ostergaard, Mikkel ; Backhaus, Marina ; Grassi, Walter ; Dougados, Maxime ; Burmester, Gerd R ; Saleem, Benazir ; de Miguel, Eugenio ; Estrach, Cristina ; Ikeda, Kei ; Gutierrez, Marwin ; Thompson, Robert ; Balint, Peter ; Emery, Paul
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ispartofPostgraduate Medical Journal August 2012, Vol.88(1042), p.482
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descriptionFor patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.
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titleAfter treat-to-target: can a targeted ultrasound initiative improve RA outcomes?
descriptionFor patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.
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abstractFor patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.
pubThe Fellowship of Postgraduate Medicine
doi10.1136/postgradmedj-2011-201048rep
urlhttp://pmj.bmj.com/content/88/1042/482.full.pdf
pmid22822227
pages482-486
date2012-08