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Medium-chain fatty acid nanoliposomes suppress body fat accumulation in mice

Medium-chain fatty acids (MCFA) are widely used in diets for patients with obesity. To develop a delivery system for suppressing dietary fat accumulation into adipose tissue, MCFA were encapsulated in nanoliposomes (NL), which can overcome the drawbacks of MCFA and keep their properties unchanged. I... Full description

Journal Title: British Journal of Nutrition 2011, Vol.106(9), pp.1330-1336
Main Author: Liu, Wei-lin
Other Authors: Liu, Wei , Liu, Cheng-mei , Yang, Shui-bing , Liu, Jian-hua , Zheng, Hui-juan , Su, Kun-ming
Format: Electronic Article Electronic Article
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ID: ISSN: 0007-1145 ; E-ISSN: 1475-2662 ; DOI: 10.1017/S0007114511002789
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title: Medium-chain fatty acid nanoliposomes suppress body fat accumulation in mice
format: Article
creator:
  • Liu, Wei-lin
  • Liu, Wei
  • Liu, Cheng-mei
  • Yang, Shui-bing
  • Liu, Jian-hua
  • Zheng, Hui-juan
  • Su, Kun-ming
subjects:
  • Molecular Nutrition
  • Medium-chain Fatty Acids
  • Nanoliposomes
  • Dynamic High-pressure Microfluidisation
  • Body Fat
ispartof: British Journal of Nutrition, 2011, Vol.106(9), pp.1330-1336
description: Medium-chain fatty acids (MCFA) are widely used in diets for patients with obesity. To develop a delivery system for suppressing dietary fat accumulation into adipose tissue, MCFA were encapsulated in nanoliposomes (NL), which can overcome the drawbacks of MCFA and keep their properties unchanged. In the present study, crude liposomes were first produced by the thin-layer dispersion method, and then dynamic high-pressure microfluidisation (DHPM) and DHPM combined with freeze–thawing methods were used to prepare MCFA NL (NL-1 and NL-2, respectively). NL-1 exhibited smaller average size (77·6 ( sd 4·3) nm), higher zeta potential ( − 40·8 ( sd 1·7) mV) and entrapment efficiency (73·3 ( sd 16·1) %) and better stability, while NL-2 showed narrower distribution (polydispersion index 0·193 ( sd 0·016)). The body fat reduction property of NL-1 and NL-2 were evaluated by short-term (2 weeks) and long-term (6 weeks) experiments of mice. In contrast to the MCFA group, the NL groups had overcome the poor palatability of MCFA because the normal diet of mice was maintained. The body fat and total cholesterol (TCH) of NL-1 (1·54 ( sd 0·30) g, P  = 0·039 and 2·33 ( sd 0·44) mmol/l, P  = 0·021, respectively) and NL-2 (1·58 ( sd 0·69) g, P  = 0·041 and 2·29 ( sd 0·38) mmol/l, P  = 0·015, respectively) significantly decreased when compared with the control group (2·11 ( sd 0·82) g and 2·99 ( sd 0·48) mmol/l, respectively). The TAG concentration of the NL-1 group (0·55 ( sd 0·14) mmol/l) was remarkably lower ( P  = 0·045) than the control group (0·94 ( sd 0·37) mmol/l). No significant difference in weight and fat gain, TCH and TAG was detected between the MCFA NL and MCFA groups. Therefore, MCFA NL could be potential nutritional candidates for obesity to suppress body fat accumulation.
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identifier: ISSN: 0007-1145 ; E-ISSN: 1475-2662 ; DOI: 10.1017/S0007114511002789
fulltext: fulltext
issn:
  • 00071145
  • 0007-1145
  • 14752662
  • 1475-2662
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titleMedium-chain fatty acid nanoliposomes suppress body fat accumulation in mice
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subjectMolecular Nutrition; Medium-chain Fatty Acids; Nanoliposomes; Dynamic High-pressure Microfluidisation; Body Fat
descriptionMedium-chain fatty acids (MCFA) are widely used in diets for patients with obesity. To develop a delivery system for suppressing dietary fat accumulation into adipose tissue, MCFA were encapsulated in nanoliposomes (NL), which can overcome the drawbacks of MCFA and keep their properties unchanged. In the present study, crude liposomes were first produced by the thin-layer dispersion method, and then dynamic high-pressure microfluidisation (DHPM) and DHPM combined with freeze–thawing methods were used to prepare MCFA NL (NL-1 and NL-2, respectively). NL-1 exhibited smaller average size (77·6 ( sd 4·3) nm), higher zeta potential ( − 40·8 ( sd 1·7) mV) and entrapment efficiency (73·3 ( sd 16·1) %) and better stability, while NL-2 showed narrower distribution (polydispersion index 0·193 ( sd 0·016)). The body fat reduction property of NL-1 and NL-2 were evaluated by short-term (2 weeks) and long-term (6 weeks) experiments of mice. In contrast to the MCFA group, the NL groups had overcome the poor palatability of MCFA because the normal diet of mice was maintained. The body fat and total cholesterol (TCH) of NL-1 (1·54 ( sd 0·30) g, P  = 0·039 and 2·33 ( sd 0·44) mmol/l, P  = 0·021, respectively) and NL-2 (1·58 ( sd 0·69) g, P  = 0·041 and 2·29 ( sd 0·38) mmol/l, P  = 0·015, respectively) significantly decreased when compared with the control group (2·11 ( sd 0·82) g and 2·99 ( sd 0·48) mmol/l, respectively). The TAG concentration of the NL-1 group (0·55 ( sd 0·14) mmol/l) was remarkably lower ( P  = 0·045) than the control group (0·94 ( sd 0·37) mmol/l). No significant difference in weight and fat gain, TCH and TAG was detected between the MCFA NL and MCFA groups. Therefore, MCFA NL could be potential nutritional candidates for obesity to suppress body fat accumulation.
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titleMedium-chain fatty acid nanoliposomes suppress body fat accumulation in mice
descriptionMedium-chain fatty acids (MCFA) are widely used in diets for patients with obesity. To develop a delivery system for suppressing dietary fat accumulation into adipose tissue, MCFA were encapsulated in nanoliposomes (NL), which can overcome the drawbacks of MCFA and keep their properties unchanged. In the present study, crude liposomes were first produced by the thin-layer dispersion method, and then dynamic high-pressure microfluidisation (DHPM) and DHPM combined with freeze–thawing methods were used to prepare MCFA NL (NL-1 and NL-2, respectively). NL-1 exhibited smaller average size (77·6 ( sd 4·3) nm), higher zeta potential ( − 40·8 ( sd 1·7) mV) and entrapment efficiency (73·3 ( sd 16·1) %) and better stability, while NL-2 showed narrower distribution (polydispersion index 0·193 ( sd 0·016)). The body fat reduction property of NL-1 and NL-2 were evaluated by short-term (2 weeks) and long-term (6 weeks) experiments of mice. In contrast to the MCFA group, the NL groups had overcome the poor palatability of MCFA because the normal diet of mice was maintained. The body fat and total cholesterol (TCH) of NL-1 (1·54 ( sd 0·30) g, P  = 0·039 and 2·33 ( sd 0·44) mmol/l, P  = 0·021, respectively) and NL-2 (1·58 ( sd 0·69) g, P  = 0·041 and 2·29 ( sd 0·38) mmol/l, P  = 0·015, respectively) significantly decreased when compared with the control group (2·11 ( sd 0·82) g and 2·99 ( sd 0·48) mmol/l, respectively). The TAG concentration of the NL-1 group (0·55 ( sd 0·14) mmol/l) was remarkably lower ( P  = 0·045) than the control group (0·94 ( sd 0·37) mmol/l). No significant difference in weight and fat gain, TCH and TAG was detected between the MCFA NL and MCFA groups. Therefore, MCFA NL could be potential nutritional candidates for obesity to suppress body fat accumulation.
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abstractMedium-chain fatty acids (MCFA) are widely used in diets for patients with obesity. To develop a delivery system for suppressing dietary fat accumulation into adipose tissue, MCFA were encapsulated in nanoliposomes (NL), which can overcome the drawbacks of MCFA and keep their properties unchanged. In the present study, crude liposomes were first produced by the thin-layer dispersion method, and then dynamic high-pressure microfluidisation (DHPM) and DHPM combined with freeze–thawing methods were used to prepare MCFA NL (NL-1 and NL-2, respectively). NL-1 exhibited smaller average size (77·6 ( sd 4·3) nm), higher zeta potential ( − 40·8 ( sd 1·7) mV) and entrapment efficiency (73·3 ( sd 16·1) %) and better stability, while NL-2 showed narrower distribution (polydispersion index 0·193 ( sd 0·016)). The body fat reduction property of NL-1 and NL-2 were evaluated by short-term (2 weeks) and long-term (6 weeks) experiments of mice. In contrast to the MCFA group, the NL groups had overcome the poor palatability of MCFA because the normal diet of mice was maintained. The body fat and total cholesterol (TCH) of NL-1 (1·54 ( sd 0·30) g, P  = 0·039 and 2·33 ( sd 0·44) mmol/l, P  = 0·021, respectively) and NL-2 (1·58 ( sd 0·69) g, P  = 0·041 and 2·29 ( sd 0·38) mmol/l, P  = 0·015, respectively) significantly decreased when compared with the control group (2·11 ( sd 0·82) g and 2·99 ( sd 0·48) mmol/l, respectively). The TAG concentration of the NL-1 group (0·55 ( sd 0·14) mmol/l) was remarkably lower ( P  = 0·045) than the control group (0·94 ( sd 0·37) mmol/l). No significant difference in weight and fat gain, TCH and TAG was detected between the MCFA NL and MCFA groups. Therefore, MCFA NL could be potential nutritional candidates for obesity to suppress body fat accumulation.
pubCambridge University Press
doi10.1017/S0007114511002789
pages1330-1336
date2011-11-14