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Dietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese

Abstract To determine the effects of dietary Fe concentration on Mn bioavailability in rats fed inorganic or organic Mn sources, fifty-four 22-d-old male rats were randomly assigned and fed a basal diet (2·63 mg Fe/kg) supplemented with 0 (low Fe (L-Fe)), 35 (adequate Fe (A-Fe)) or 175 (high Fe (H-F... Full description

Journal Title: British Journal of Nutrition 2016, Vol.115(4), pp.585-593
Main Author: Zhang, Huaiyong
Other Authors: Gilbert, Elizabeth R , Pan, Shuqin , Zhang, Keying , Ding, Xuemei , Wang, Jianping , Zeng, Qiufeng , Bai, Shiping
Format: Electronic Article Electronic Article
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Quelle: Cambridge University Press
ID: ISSN: 0007-1145 ; E-ISSN: 1475-2662 ; DOI: 10.1017/S0007114515004900
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title: Dietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese
format: Article
creator:
  • Zhang, Huaiyong
  • Gilbert, Elizabeth R
  • Pan, Shuqin
  • Zhang, Keying
  • Ding, Xuemei
  • Wang, Jianping
  • Zeng, Qiufeng
  • Bai, Shiping
subjects:
  • Full Papers
  • Metabolism And Metabolic Studies
  • Dietary Manganese
  • Manganese–Lysine Chelate
  • Serum Manganese
  • Dietary Iron
  • Rats
ispartof: British Journal of Nutrition, 2016, Vol.115(4), pp.585-593
description: Abstract To determine the effects of dietary Fe concentration on Mn bioavailability in rats fed inorganic or organic Mn sources, fifty-four 22-d-old male rats were randomly assigned and fed a basal diet (2·63 mg Fe/kg) supplemented with 0 (low Fe (L-Fe)), 35 (adequate Fe (A-Fe)) or 175 (high Fe (H-Fe)) mg Fe/kg with 10 mg Mn/kg from MnSO 4 or Mn–lysine chelate (MnLys). Tissues were harvested after 21 d of feeding. Serum Mn was greater ( P
language:
source: Cambridge University Press
identifier: ISSN: 0007-1145 ; E-ISSN: 1475-2662 ; DOI: 10.1017/S0007114515004900
fulltext: fulltext
issn:
  • 00071145
  • 0007-1145
  • 14752662
  • 1475-2662
url: Link


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titleDietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese
creatorZhang, Huaiyong ; Gilbert, Elizabeth R ; Pan, Shuqin ; Zhang, Keying ; Ding, Xuemei ; Wang, Jianping ; Zeng, Qiufeng ; Bai, Shiping
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subjectFull Papers; Metabolism And Metabolic Studies; Dietary Manganese; Manganese–Lysine Chelate; Serum Manganese; Dietary Iron; Rats
descriptionAbstract To determine the effects of dietary Fe concentration on Mn bioavailability in rats fed inorganic or organic Mn sources, fifty-four 22-d-old male rats were randomly assigned and fed a basal diet (2·63 mg Fe/kg) supplemented with 0 (low Fe (L-Fe)), 35 (adequate Fe (A-Fe)) or 175 (high Fe (H-Fe)) mg Fe/kg with 10 mg Mn/kg from MnSO 4 or Mn–lysine chelate (MnLys). Tissues were harvested after 21 d of feeding. Serum Mn was greater ( P <0·05) in MnLys rats than in MnSO 4 rats, and in L-Fe rats than in A-Fe or H-Fe rats. Duodenal divalent metal transporter-1 (DMT1) mRNA was lower ( P <0·05) in H-Fe rats than in A-Fe rats for the MnSO 4 treatment; however, no significant difference was observed between them for MnLys. Liver DMT1 mRNA abundance was greater ( P <0·05) in MnSO 4 than in the MnLys group for H-Fe rats. The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater ( P <0·05) in the MnSO 4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats. Duodenal FPN1 protein was greater ( P <0·05) in L-Fe rats than in A-Fe rats for the MnLys treatment, but it was not different between them for the MnSO 4 treatment. Results suggest that MnLys increased serum Mn concentration as compared with MnSO 4 in rats irrespective of dietary Fe concentration, which was not because of the difference in DMT1 and FPN1 expression in the intestine and liver.
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titleDietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese
descriptionAbstract To determine the effects of dietary Fe concentration on Mn bioavailability in rats fed inorganic or organic Mn sources, fifty-four 22-d-old male rats were randomly assigned and fed a basal diet (2·63 mg Fe/kg) supplemented with 0 (low Fe (L-Fe)), 35 (adequate Fe (A-Fe)) or 175 (high Fe (H-Fe)) mg Fe/kg with 10 mg Mn/kg from MnSO 4 or Mn–lysine chelate (MnLys). Tissues were harvested after 21 d of feeding. Serum Mn was greater ( P <0·05) in MnLys rats than in MnSO 4 rats, and in L-Fe rats than in A-Fe or H-Fe rats. Duodenal divalent metal transporter-1 (DMT1) mRNA was lower ( P <0·05) in H-Fe rats than in A-Fe rats for the MnSO 4 treatment; however, no significant difference was observed between them for MnLys. Liver DMT1 mRNA abundance was greater ( P <0·05) in MnSO 4 than in the MnLys group for H-Fe rats. The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater ( P <0·05) in the MnSO 4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats. Duodenal FPN1 protein was greater ( P <0·05) in L-Fe rats than in A-Fe rats for the MnLys treatment, but it was not different between them for the MnSO 4 treatment. Results suggest that MnLys increased serum Mn concentration as compared with MnSO 4 in rats irrespective of dietary Fe concentration, which was not because of the difference in DMT1 and FPN1 expression in the intestine and liver.
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abstractAbstract To determine the effects of dietary Fe concentration on Mn bioavailability in rats fed inorganic or organic Mn sources, fifty-four 22-d-old male rats were randomly assigned and fed a basal diet (2·63 mg Fe/kg) supplemented with 0 (low Fe (L-Fe)), 35 (adequate Fe (A-Fe)) or 175 (high Fe (H-Fe)) mg Fe/kg with 10 mg Mn/kg from MnSO 4 or Mn–lysine chelate (MnLys). Tissues were harvested after 21 d of feeding. Serum Mn was greater ( P <0·05) in MnLys rats than in MnSO 4 rats, and in L-Fe rats than in A-Fe or H-Fe rats. Duodenal divalent metal transporter-1 (DMT1) mRNA was lower ( P <0·05) in H-Fe rats than in A-Fe rats for the MnSO 4 treatment; however, no significant difference was observed between them for MnLys. Liver DMT1 mRNA abundance was greater ( P <0·05) in MnSO 4 than in the MnLys group for H-Fe rats. The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater ( P <0·05) in the MnSO 4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats. Duodenal FPN1 protein was greater ( P <0·05) in L-Fe rats than in A-Fe rats for the MnLys treatment, but it was not different between them for the MnSO 4 treatment. Results suggest that MnLys increased serum Mn concentration as compared with MnSO 4 in rats irrespective of dietary Fe concentration, which was not because of the difference in DMT1 and FPN1 expression in the intestine and liver.
pubCambridge University Press
doi10.1017/S0007114515004900
pages585-58593
date2016-02-28