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Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss

Abstract Objectives: To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Methods: Thirty-two patients with idiopathic sudden sensor... Full description

Journal Title: The Journal of Laryngology & Otology 2016, Vol.130(5), pp.447-452
Main Author: Dinc, M E
Other Authors: Ulusoy, S , Is, A , Ayan, N N , Avincsal, M O , Bicer, C , Erel, O
Format: Electronic Article Electronic Article
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ID: ISSN: 0022-2151 ; E-ISSN: 1748-5460 ; DOI: 10.1017/S002221511600092X
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title: Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
format: Article
creator:
  • Dinc, M E
  • Ulusoy, S
  • Is, A
  • Ayan, N N
  • Avincsal, M O
  • Bicer, C
  • Erel, O
subjects:
  • Main Articles
  • Thiols
  • Disulfides
  • Hearing Loss, Sudden
  • Oxidative Stress
  • Reactive Oxygen Species
ispartof: The Journal of Laryngology & Otology, 2016, Vol.130(5), pp.447-452
description: Abstract Objectives: To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Methods: Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects. Results: Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls ( p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002). Conclusion: The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.
language:
source:
identifier: ISSN: 0022-2151 ; E-ISSN: 1748-5460 ; DOI: 10.1017/S002221511600092X
fulltext: fulltext
issn:
  • 00222151
  • 0022-2151
  • 17485460
  • 1748-5460
url: Link


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titleThiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
creatorDinc, M E ; Ulusoy, S ; Is, A ; Ayan, N N ; Avincsal, M O ; Bicer, C ; Erel, O
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subjectMain Articles; Thiols; Disulfides; Hearing Loss, Sudden; Oxidative Stress; Reactive Oxygen Species
descriptionAbstract Objectives: To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Methods: Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects. Results: Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls ( p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002). Conclusion: The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.
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titleThiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
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abstractAbstract Objectives: To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Methods: Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects. Results: Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls ( p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002). Conclusion: The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.
pubCambridge University Press
doi10.1017/S002221511600092X
pages447-452
date2016-05