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Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.

The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty aci... Full description

Main Author: Sala Vila, Aleix
Other Authors: Harris, William S , Cofán Pujol, Montserrat , Pérez - Heras, Ana Maria , Pintó Sala, Xavier , Lamuela Raventós, Rosa Ma , Covas Planells, María Isabel , Estruch Riba, Ramon , Ros Rahola, Emilio
Format: Electronic Article Electronic Article
Language: English
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Quelle: RECERCAT (Dipòsit de la Recerca de Catalunya)
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recordid: cbuc_cat2072/218066
title: Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.
format: Article
creator:
  • Sala Vila, Aleix
  • Harris, William S
  • Cofán Pujol, Montserrat
  • Pérez - Heras, Ana Maria
  • Pintó Sala, Xavier
  • Lamuela Raventós, Rosa Ma
  • Covas Planells, María Isabel
  • Estruch Riba, Ramon
  • Ros Rahola, Emilio
subjects:
  • Dieta
  • Malalties Cardiovasculars
  • Factors De Risc En Les Malalties
  • Àcids Grassos Omega - 3
  • Diet
  • Cardiovascular Diseases
  • Risk Factors In Diseases
  • Omega - 3 Fatty Acids
ispartof:
description: The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
language: eng
source: RECERCAT (Dipòsit de la Recerca de Catalunya)
identifier:
fulltext: fulltext_linktorsrc
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titleDeterminants of the omega-3 index in a Mediterranean population at increased risk for CHD.
creatorSala Vila, Aleix ; Harris, William S ; Cofán Pujol, Montserrat ; Pérez - Heras, Ana Maria ; Pintó Sala, Xavier ; Lamuela Raventós, Rosa Ma ; Covas Planells, María Isabel ; Estruch Riba, Ramon ; Ros Rahola, Emilio
contributorUniversitat De Barcelona
subjectDieta ; Malalties Cardiovasculars ; Factors De Risc En Les Malalties ; Àcids Grassos Omega - 3 ; Diet ; Cardiovascular Diseases ; Risk Factors In Diseases ; Omega - 3 Fatty Acids
descriptionThe omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
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titleDeterminants of the omega-3 index in a Mediterranean population at increased risk for CHD.
descriptionThe omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
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titleDeterminants of the omega-3 index in a Mediterranean population at increased risk for CHD.
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5Lamuela Raventós, Rosa Ma
6Covas Planells, María Isabel
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abstractThe omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
pubCambridge University Press
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