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Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide

RATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic an... Full description

Main Author: Chiva Blanch, Gemma
Other Authors: Urpí Sardà, Mireia , Ros Rahola, Emilio , Arranz Martínez, Sara , Valderas Martínez, Palmira , Casas, Rosa , Sacanella Meseguer, Emilio , Llorach, Rafael , Lamuela Raventós, Rosa Ma , Andrés Lacueva, Ma. Cristina , Estruch Riba, Ramon
Format: Electronic Article Electronic Article
Language: English
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Quelle: RECERCAT (Dipòsit de la Recerca de Catalunya)
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recordid: cbuc_cat2072/281244
title: Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
format: Article
creator:
  • Chiva Blanch, Gemma
  • Urpí Sardà, Mireia
  • Ros Rahola, Emilio
  • Arranz Martínez, Sara
  • Valderas Martínez, Palmira
  • Casas, Rosa
  • Sacanella Meseguer, Emilio
  • Llorach, Rafael
  • Lamuela Raventós, Rosa Ma
  • Andrés Lacueva, Ma. Cristina
  • Estruch Riba, Ramon
subjects:
  • Vi Negre
  • Polifenols
  • Alcohol
  • Òxid Nítric
  • Pressió Sanguínia
  • Red Wines
  • Polyphenols
  • Alcohol
  • Nitric Oxide
  • Blood Pressure
ispartof:
description: RATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk. METHODS AND RESULTS: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO. CONCLUSIONS: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com: ISRCTN88720134.
language: eng
source: RECERCAT (Dipòsit de la Recerca de Catalunya)
identifier:
fulltext: fulltext_linktorsrc
url: Link


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titleDealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
creatorChiva Blanch, Gemma ; Urpí Sardà, Mireia ; Ros Rahola, Emilio ; Arranz Martínez, Sara ; Valderas Martínez, Palmira ; Casas, Rosa ; Sacanella Meseguer, Emilio ; Llorach, Rafael ; Lamuela Raventós, Rosa Ma ; Andrés Lacueva, Ma. Cristina ; Estruch Riba, Ramon
contributorUniversitat De Barcelona
subjectVi Negre ; Polifenols ; Alcohol ; Òxid Nítric ; Pressió Sanguínia ; Red Wines ; Polyphenols ; Alcohol ; Nitric Oxide ; Blood Pressure
descriptionRATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk. METHODS AND RESULTS: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO. CONCLUSIONS: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com: ISRCTN88720134.
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6Sacanella Meseguer, Emilio
7Llorach, Rafael
8Lamuela Raventós, Rosa Ma.
9Andrés Lacueva, Ma. Cristina
10Estruch Riba, Ramon
11Universitat de Barcelona
titleDealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
descriptionRATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk. METHODS AND RESULTS: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO. CONCLUSIONS: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com: ISRCTN88720134.
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titleDealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
authorChiva Blanch, Gemma ; Urpí Sardà, Mireia ; Ros Rahola, Emilio ; Arranz Martínez, Sara ; Valderas Martínez, Palmira ; Casas, Rosa ; Sacanella Meseguer, Emilio ; Llorach, Rafael ; Lamuela Raventós, Rosa Ma ; Andrés Lacueva, Ma. Cristina ; Estruch Riba, Ramon
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7Nitric Oxide
8Blood Pressure
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5Casas, Rosa
6Sacanella Meseguer, Emilio
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1Urpí Sardà, Mireia
2Ros Rahola, Emilio
3Arranz Martínez, Sara
4Valderas Martínez, Palmira
5Casas, Rosa
6Sacanella Meseguer, Emilio
7Llorach, Rafael
8Lamuela Raventós, Rosa Ma
9Andrés Lacueva, Ma. Cristina
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atitleDealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
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abstractRATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk. METHODS AND RESULTS: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO. CONCLUSIONS: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com: ISRCTN88720134.
pubLippincott, Williams & Wilkins
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