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Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine

Migraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine. Clinical trials carried out during the past decade have proved that... Full description

Journal Title: Annual review of pharmacology and toxicology 2015-01-06, Vol.55 (1), p.533-552
Main Author: Russo, Andrew F
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Annual Reviews
ID: ISSN: 0362-1642
Link: https://www.ncbi.nlm.nih.gov/pubmed/25340934
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recordid: cdi_annualreviews_primary_10_1146_annurev_pharmtox_010814_124701
title: Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine
format: Article
creator:
  • Russo, Andrew F
subjects:
  • Analgesics - therapeutic use
  • Animals
  • Antibodies, Monoclonal - therapeutic use
  • Article
  • Calcitonin Gene-Related Peptide - antagonists & inhibitors
  • Calcitonin Gene-Related Peptide - genetics
  • Calcitonin Gene-Related Peptide - immunology
  • Calcitonin Gene-Related Peptide - metabolism
  • Drug Design
  • Epigenesis, Genetic - drug effects
  • Epistasis, Genetic - drug effects
  • Humans
  • integumentary system
  • Migraine Disorders - drug therapy
  • Migraine Disorders - genetics
  • Migraine Disorders - metabolism
  • Migraine Disorders - physiopathology
  • Molecular Targeted Therapy - methods
  • nervous system
  • Neural Pathways - drug effects
  • Neural Pathways - metabolism
  • Neural Pathways - physiopathology
  • neuromodulation
  • neuropeptide
  • Pain Perception - drug effects
  • Pain Threshold - drug effects
  • photophobia
  • Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors
  • Receptors, Calcitonin Gene-Related Peptide - genetics
  • Receptors, Calcitonin Gene-Related Peptide - immunology
  • Receptors, Calcitonin Gene-Related Peptide - metabolism
  • sensitization
  • Signal Transduction - drug effects
  • trigeminovasculature
ispartof: Annual review of pharmacology and toxicology, 2015-01-06, Vol.55 (1), p.533-552
description: Migraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine. Clinical trials carried out during the past decade have proved that CGRP receptor antagonists are effective for treating migraine, and antibodies to the receptor and CGRP are currently under investigation. Despite this progress in the clinical arena, the mechanisms by which CGRP triggers migraine remain uncertain. This review discusses mechanisms whereby CGRP enhances sensitivity to sensory input at multiple levels in both the periphery and central nervous system. Future studies on epistatic and epigenetic regulators of CGRP actions are expected to shed further light on CGRP actions in migraine. In conclusion, targeting CGRP represents an approachable therapeutic strategy for migraine.
language: eng
source:
identifier: ISSN: 0362-1642
fulltext: no_fulltext
issn:
  • 0362-1642
  • 1545-4304
url: Link


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descriptionMigraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine. Clinical trials carried out during the past decade have proved that CGRP receptor antagonists are effective for treating migraine, and antibodies to the receptor and CGRP are currently under investigation. Despite this progress in the clinical arena, the mechanisms by which CGRP triggers migraine remain uncertain. This review discusses mechanisms whereby CGRP enhances sensitivity to sensory input at multiple levels in both the periphery and central nervous system. Future studies on epistatic and epigenetic regulators of CGRP actions are expected to shed further light on CGRP actions in migraine. In conclusion, targeting CGRP represents an approachable therapeutic strategy for migraine.
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subjectAnalgesics - therapeutic use ; Animals ; Antibodies, Monoclonal - therapeutic use ; Article ; Calcitonin Gene-Related Peptide - antagonists & inhibitors ; Calcitonin Gene-Related Peptide - genetics ; Calcitonin Gene-Related Peptide - immunology ; Calcitonin Gene-Related Peptide - metabolism ; Drug Design ; Epigenesis, Genetic - drug effects ; Epistasis, Genetic - drug effects ; Humans ; integumentary system ; Migraine Disorders - drug therapy ; Migraine Disorders - genetics ; Migraine Disorders - metabolism ; Migraine Disorders - physiopathology ; Molecular Targeted Therapy - methods ; nervous system ; Neural Pathways - drug effects ; Neural Pathways - metabolism ; Neural Pathways - physiopathology ; neuromodulation ; neuropeptide ; Pain Perception - drug effects ; Pain Threshold - drug effects ; photophobia ; Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors ; Receptors, Calcitonin Gene-Related Peptide - genetics ; Receptors, Calcitonin Gene-Related Peptide - immunology ; Receptors, Calcitonin Gene-Related Peptide - metabolism ; sensitization ; Signal Transduction - drug effects ; trigeminovasculature
ispartofAnnual review of pharmacology and toxicology, 2015-01-06, Vol.55 (1), p.533-552
rightsCopyright © 2015 by Annual Reviews. All rights reserved 2015
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descriptionMigraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine. Clinical trials carried out during the past decade have proved that CGRP receptor antagonists are effective for treating migraine, and antibodies to the receptor and CGRP are currently under investigation. Despite this progress in the clinical arena, the mechanisms by which CGRP triggers migraine remain uncertain. This review discusses mechanisms whereby CGRP enhances sensitivity to sensory input at multiple levels in both the periphery and central nervous system. Future studies on epistatic and epigenetic regulators of CGRP actions are expected to shed further light on CGRP actions in migraine. In conclusion, targeting CGRP represents an approachable therapeutic strategy for migraine.
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0Analgesics - therapeutic use
1Animals
2Antibodies, Monoclonal - therapeutic use
3Article
4Calcitonin Gene-Related Peptide - antagonists & inhibitors
5Calcitonin Gene-Related Peptide - genetics
6Calcitonin Gene-Related Peptide - immunology
7Calcitonin Gene-Related Peptide - metabolism
8Drug Design
9Epigenesis, Genetic - drug effects
10Epistasis, Genetic - drug effects
11Humans
12integumentary system
13Migraine Disorders - drug therapy
14Migraine Disorders - genetics
15Migraine Disorders - metabolism
16Migraine Disorders - physiopathology
17Molecular Targeted Therapy - methods
18nervous system
19Neural Pathways - drug effects
20Neural Pathways - metabolism
21Neural Pathways - physiopathology
22neuromodulation
23neuropeptide
24Pain Perception - drug effects
25Pain Threshold - drug effects
26photophobia
27Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors
28Receptors, Calcitonin Gene-Related Peptide - genetics
29Receptors, Calcitonin Gene-Related Peptide - immunology
30Receptors, Calcitonin Gene-Related Peptide - metabolism
31sensitization
32Signal Transduction - drug effects
33trigeminovasculature
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10Epistasis, Genetic - drug effects
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14Migraine Disorders - genetics
15Migraine Disorders - metabolism
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27Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors
28Receptors, Calcitonin Gene-Related Peptide - genetics
29Receptors, Calcitonin Gene-Related Peptide - immunology
30Receptors, Calcitonin Gene-Related Peptide - metabolism
31sensitization
32Signal Transduction - drug effects
33trigeminovasculature
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abstractMigraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine. Clinical trials carried out during the past decade have proved that CGRP receptor antagonists are effective for treating migraine, and antibodies to the receptor and CGRP are currently under investigation. Despite this progress in the clinical arena, the mechanisms by which CGRP triggers migraine remain uncertain. This review discusses mechanisms whereby CGRP enhances sensitivity to sensory input at multiple levels in both the periphery and central nervous system. Future studies on epistatic and epigenetic regulators of CGRP actions are expected to shed further light on CGRP actions in migraine. In conclusion, targeting CGRP represents an approachable therapeutic strategy for migraine.
copUnited States
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pmid25340934
doi10.1146/annurev-pharmtox-010814-124701
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