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The pharmacokinetics of fenbendazole and oxfendazole in cattle

The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrat... Full description

Journal Title: Veterinary research communications 1984-08, Vol.8 (3), p.187-193
Main Author: Ngomuo, A J
Other Authors: Marriner, S E , Bogan, J A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Netherlands
ID: ISSN: 0165-7380
Link: https://www.ncbi.nlm.nih.gov/pubmed/6495635
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recordid: cdi_crossref_primary_10_1007_BF02214711
title: The pharmacokinetics of fenbendazole and oxfendazole in cattle
format: Article
creator:
  • Ngomuo, A J
  • Marriner, S E
  • Bogan, J A
subjects:
  • Animals
  • Benzimidazoles - administration & dosage
  • Benzimidazoles - metabolism
  • Cattle - metabolism
  • Cattle Diseases - drug therapy
  • Female
  • Fenbendazole - administration & dosage
  • Fenbendazole - metabolism
  • Kinetics
  • Male
ispartof: Veterinary research communications, 1984-08, Vol.8 (3), p.187-193
description: The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
language: eng
source:
identifier: ISSN: 0165-7380
fulltext: no_fulltext
issn:
  • 0165-7380
  • 1573-7446
url: Link


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descriptionThe pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
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subjectAnimals ; Benzimidazoles - administration & dosage ; Benzimidazoles - metabolism ; Cattle - metabolism ; Cattle Diseases - drug therapy ; Female ; Fenbendazole - administration & dosage ; Fenbendazole - metabolism ; Kinetics ; Male
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descriptionThe pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
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abstractThe pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
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