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Cellular mechanism of action of loop diuretics: Implications for drug effectiveness and adverse effects

The loop diuretics inhibit a transport system that moves sodium, potassium and chloride across cell membranes of many tissues, including the thick ascending loop of Henle. This inhibitory effect is responsible for their natriuretic effect. Of the agents available for clinical use, bumetanide is the... Full description

Journal Title: The American journal of cardiology 1986, Vol.57 (2), p.A14-A19
Main Author: Feig, Peter U
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0002-9149
Link: https://www.ncbi.nlm.nih.gov/pubmed/3511652
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recordid: cdi_crossref_primary_10_1016_0002_9149_86_91001_5
title: Cellular mechanism of action of loop diuretics: Implications for drug effectiveness and adverse effects
format: Article
creator:
  • Feig, Peter U
subjects:
  • Animals
  • Chlorides - metabolism
  • Diuretics - adverse effects
  • Diuretics - pharmacology
  • Dose-Response Relationship, Drug
  • Drug Resistance
  • Erythrocyte Membrane - drug effects
  • Hearing - drug effects
  • Humans
  • Hyperglycemia - chemically induced
  • Hypokalemia - chemically induced
  • Kidney Tubules - drug effects
  • Loop of Henle - drug effects
  • Loop of Henle - physiology
  • Models, Biological
  • Potassium - metabolism
  • Sodium - metabolism
  • Sulfonamides
  • Uric Acid - blood
ispartof: The American journal of cardiology, 1986, Vol.57 (2), p.A14-A19
description: The loop diuretics inhibit a transport system that moves sodium, potassium and chloride across cell membranes of many tissues, including the thick ascending loop of Henle. This inhibitory effect is responsible for their natriuretic effect. Of the agents available for clinical use, bumetanide is the most powerful; it has an in vitro transport inhibitory potency and an in vivo natriuretic effectiveness that is approximately 50-fold that of furosemide. This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9149
fulltext: fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleCellular mechanism of action of loop diuretics: Implications for drug effectiveness and adverse effects
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descriptionThe loop diuretics inhibit a transport system that moves sodium, potassium and chloride across cell membranes of many tissues, including the thick ascending loop of Henle. This inhibitory effect is responsible for their natriuretic effect. Of the agents available for clinical use, bumetanide is the most powerful; it has an in vitro transport inhibitory potency and an in vivo natriuretic effectiveness that is approximately 50-fold that of furosemide. This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects.
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subjectAnimals ; Chlorides - metabolism ; Diuretics - adverse effects ; Diuretics - pharmacology ; Dose-Response Relationship, Drug ; Drug Resistance ; Erythrocyte Membrane - drug effects ; Hearing - drug effects ; Humans ; Hyperglycemia - chemically induced ; Hypokalemia - chemically induced ; Kidney Tubules - drug effects ; Loop of Henle - drug effects ; Loop of Henle - physiology ; Models, Biological ; Potassium - metabolism ; Sodium - metabolism ; Sulfonamides ; Uric Acid - blood
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descriptionThe loop diuretics inhibit a transport system that moves sodium, potassium and chloride across cell membranes of many tissues, including the thick ascending loop of Henle. This inhibitory effect is responsible for their natriuretic effect. Of the agents available for clinical use, bumetanide is the most powerful; it has an in vitro transport inhibitory potency and an in vivo natriuretic effectiveness that is approximately 50-fold that of furosemide. This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects.
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18Uric Acid - blood
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1Chlorides - metabolism
2Diuretics - adverse effects
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6Erythrocyte Membrane - drug effects
7Hearing - drug effects
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abstractThe loop diuretics inhibit a transport system that moves sodium, potassium and chloride across cell membranes of many tissues, including the thick ascending loop of Henle. This inhibitory effect is responsible for their natriuretic effect. Of the agents available for clinical use, bumetanide is the most powerful; it has an in vitro transport inhibitory potency and an in vivo natriuretic effectiveness that is approximately 50-fold that of furosemide. This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects.
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pmid3511652
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