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Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics

The concentration of acetate was determined in the hepatic and peripheral blood of 10 chronic alcoholics and six healthy non-alcoholic controls after a peroral dose of ethanol (0.8 g/kg b.wt.). The blood acetate concentration was significantly higher in the hepatic vein than peripherally and remaine... Full description

Journal Title: Alcohol (Fayetteville N.Y.), 1985, Vol.2 (4), p.623-626
Main Author: Nuutinen, H
Other Authors: Lindros, K , Hekali, P , Salaspuro, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0741-8329
Link: https://www.ncbi.nlm.nih.gov/pubmed/4026986
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recordid: cdi_crossref_primary_10_1016_0741_8329_85_90090_4
title: Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics
format: Article
creator:
  • Nuutinen, H
  • Lindros, K
  • Hekali, P
  • Salaspuro, M
subjects:
  • Acetates - blood
  • Adult
  • Alcohol metabolism
  • Alcoholism - blood
  • Ethanol - blood
  • Human blood acetate
  • Humans
  • Liver - metabolism
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
ispartof: Alcohol (Fayetteville, N.Y.), 1985, Vol.2 (4), p.623-626
description: The concentration of acetate was determined in the hepatic and peripheral blood of 10 chronic alcoholics and six healthy non-alcoholic controls after a peroral dose of ethanol (0.8 g/kg b.wt.). The blood acetate concentration was significantly higher in the hepatic vein than peripherally and remained at a rather constant level both in alcoholics and controls during the course of ethanol elimination. However, the level of acetate was significantly ( p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0741-8329
fulltext: fulltext
issn:
  • 0741-8329
  • 1873-6823
url: Link


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titleElevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics
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descriptionThe concentration of acetate was determined in the hepatic and peripheral blood of 10 chronic alcoholics and six healthy non-alcoholic controls after a peroral dose of ethanol (0.8 g/kg b.wt.). The blood acetate concentration was significantly higher in the hepatic vein than peripherally and remained at a rather constant level both in alcoholics and controls during the course of ethanol elimination. However, the level of acetate was significantly ( p<0.005) higher in alcoholics than in controls both in the hepatic vein (1.79 and 1.15 mM) and peripherally (0.91 and 0.52 mM) (alcoholics and controls respectively). The alcoholics also eliminated ethanol 54% faster than the controls (159 mg/kg b.wt./hr and 103 mg/kg b.wt./hr; alcoholics and controls respectively). Furthermore a highly significant correlation was found between the rate of ethanol elimination and blood acetate level both in the hepatic (r=0.877, p<0.001) and in the peripheral vein (r=0.799, p<0.001). Our results suggest that an increased level of blood acetate during ethanol oxidation may be used as an indicator of enhanced ethanol elimination.
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subjectAcetates - blood ; Adult ; Alcohol metabolism ; Alcoholism - blood ; Ethanol - blood ; Human blood acetate ; Humans ; Liver - metabolism ; Male ; Metabolic Clearance Rate ; Middle Aged
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descriptionThe concentration of acetate was determined in the hepatic and peripheral blood of 10 chronic alcoholics and six healthy non-alcoholic controls after a peroral dose of ethanol (0.8 g/kg b.wt.). The blood acetate concentration was significantly higher in the hepatic vein than peripherally and remained at a rather constant level both in alcoholics and controls during the course of ethanol elimination. However, the level of acetate was significantly ( p<0.005) higher in alcoholics than in controls both in the hepatic vein (1.79 and 1.15 mM) and peripherally (0.91 and 0.52 mM) (alcoholics and controls respectively). The alcoholics also eliminated ethanol 54% faster than the controls (159 mg/kg b.wt./hr and 103 mg/kg b.wt./hr; alcoholics and controls respectively). Furthermore a highly significant correlation was found between the rate of ethanol elimination and blood acetate level both in the hepatic (r=0.877, p<0.001) and in the peripheral vein (r=0.799, p<0.001). Our results suggest that an increased level of blood acetate during ethanol oxidation may be used as an indicator of enhanced ethanol elimination.
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abstractThe concentration of acetate was determined in the hepatic and peripheral blood of 10 chronic alcoholics and six healthy non-alcoholic controls after a peroral dose of ethanol (0.8 g/kg b.wt.). The blood acetate concentration was significantly higher in the hepatic vein than peripherally and remained at a rather constant level both in alcoholics and controls during the course of ethanol elimination. However, the level of acetate was significantly ( p<0.005) higher in alcoholics than in controls both in the hepatic vein (1.79 and 1.15 mM) and peripherally (0.91 and 0.52 mM) (alcoholics and controls respectively). The alcoholics also eliminated ethanol 54% faster than the controls (159 mg/kg b.wt./hr and 103 mg/kg b.wt./hr; alcoholics and controls respectively). Furthermore a highly significant correlation was found between the rate of ethanol elimination and blood acetate level both in the hepatic (r=0.877, p<0.001) and in the peripheral vein (r=0.799, p<0.001). Our results suggest that an increased level of blood acetate during ethanol oxidation may be used as an indicator of enhanced ethanol elimination.
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doi10.1016/0741-8329(85)90090-4