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CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma

Abstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). U... Full description

Journal Title: Cancer letters 2008, Vol.276 (1), p.88-94
Main Author: He, Lijie
Other Authors: Wang, Hanmin , Jin, Haifeng , Guo, Changcun , Xie, Huahong , Yan, Kun , Li, Xiaohuai , Shen, Qing , Qiao, Taidong , Chen, Guanglei , Chai, Na , Zhao, Lina , Dong, Qingchuan , Zheng, Yan , Liu, Jie , Fan, Daiming
Format: Electronic Article Electronic Article
Language: English
Subjects:
Biomarkers, Tumor - analysis
Blotting, Western
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - metabolism
Cell culture
Cell cycle
Cell growth
Cell Proliferation
CIAPIN1
Clear cell renal cell carcinoma
Cloning
Cyclin-dependent kinases
Experiments
G1/S
Gene Expression
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Kidney cancer
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kinases
Pediatrics
Phosphorylation
Proliferation
Proteins
Rodents
Tumors
VEGF
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/19081179
Zum Text:
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recordid: cdi_crossref_primary_10_1016_j_canlet_2008_10_044
title: CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
format: Article
creator:
  • He, Lijie
  • Wang, Hanmin
  • Jin, Haifeng
  • Guo, Changcun
  • Xie, Huahong
  • Yan, Kun
  • Li, Xiaohuai
  • Shen, Qing
  • Qiao, Taidong
  • Chen, Guanglei
  • Chai, Na
  • Zhao, Lina
  • Dong, Qingchuan
  • Zheng, Yan
  • Liu, Jie
  • Fan, Daiming
subjects:
  • Biomarkers, Tumor - analysis
  • Blotting, Western
  • Carcinoma, Renal Cell - genetics
  • Carcinoma, Renal Cell - metabolism
  • Cell culture
  • Cell cycle
  • Cell growth
  • Cell Proliferation
  • CIAPIN1
  • Clear cell renal cell carcinoma
  • Cloning
  • Cyclin-dependent kinases
  • Experiments
  • G1/S
  • Gene Expression
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins - genetics
  • Intracellular Signaling Peptides and Proteins - metabolism
  • Kidney cancer
  • Kidney Neoplasms - genetics
  • Kidney Neoplasms - metabolism
  • Kinases
  • Pediatrics
  • Phosphorylation
  • Proliferation
  • Proteins
  • Rodents
  • Tumors
  • VEGF
ispartof: Cancer letters, 2008, Vol.276 (1), p.88-94
description: Abstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleCIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
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creatorHe, Lijie ; Wang, Hanmin ; Jin, Haifeng ; Guo, Changcun ; Xie, Huahong ; Yan, Kun ; Li, Xiaohuai ; Shen, Qing ; Qiao, Taidong ; Chen, Guanglei ; Chai, Na ; Zhao, Lina ; Dong, Qingchuan ; Zheng, Yan ; Liu, Jie ; Fan, Daiming
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descriptionAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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subjectBiomarkers, Tumor - analysis ; Blotting, Western ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - metabolism ; Cell culture ; Cell cycle ; Cell growth ; Cell Proliferation ; CIAPIN1 ; Clear cell renal cell carcinoma ; Cloning ; Cyclin-dependent kinases ; Experiments ; G1/S ; Gene Expression ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Kidney cancer ; Kidney Neoplasms - genetics ; Kidney Neoplasms - metabolism ; Kinases ; Pediatrics ; Phosphorylation ; Proliferation ; Proteins ; Rodents ; Tumors ; VEGF
ispartofCancer letters, 2008, Vol.276 (1), p.88-94
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10Chai, Na
11Zhao, Lina
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15Fan, Daiming
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descriptionAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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1Blotting, Western
2Carcinoma, Renal Cell - genetics
3Carcinoma, Renal Cell - metabolism
4Cell culture
5Cell cycle
6Cell growth
7Cell Proliferation
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17Immunohistochemistry
18Intracellular Signaling Peptides and Proteins - genetics
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21Kidney Neoplasms - genetics
22Kidney Neoplasms - metabolism
23Kinases
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titleCIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
authorHe, Lijie ; Wang, Hanmin ; Jin, Haifeng ; Guo, Changcun ; Xie, Huahong ; Yan, Kun ; Li, Xiaohuai ; Shen, Qing ; Qiao, Taidong ; Chen, Guanglei ; Chai, Na ; Zhao, Lina ; Dong, Qingchuan ; Zheng, Yan ; Liu, Jie ; Fan, Daiming
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1Blotting, Western
2Carcinoma, Renal Cell - genetics
3Carcinoma, Renal Cell - metabolism
4Cell culture
5Cell cycle
6Cell growth
7Cell Proliferation
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9Clear cell renal cell carcinoma
10Cloning
11Cyclin-dependent kinases
12Experiments
13G1/S
14Gene Expression
15Hematology, Oncology and Palliative Medicine
16Humans
17Immunohistochemistry
18Intracellular Signaling Peptides and Proteins - genetics
19Intracellular Signaling Peptides and Proteins - metabolism
20Kidney cancer
21Kidney Neoplasms - genetics
22Kidney Neoplasms - metabolism
23Kinases
24Pediatrics
25Phosphorylation
26Proliferation
27Proteins
28Rodents
29Tumors
30VEGF
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jtitleCancer letters
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1Wang, Hanmin
2Jin, Haifeng
3Guo, Changcun
4Xie, Huahong
5Yan, Kun
6Li, Xiaohuai
7Shen, Qing
8Qiao, Taidong
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10Chai, Na
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12Dong, Qingchuan
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jtitleCancer letters
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date2008
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pages88-94
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abstractAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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pubElsevier Ireland Ltd
pmid19081179
doi10.1016/j.canlet.2008.10.044