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CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma

Abstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). U... Full description

Journal Title: Cancer letters 2008, Vol.276 (1), p.88-94
Main Author: He, Lijie
Other Authors: Wang, Hanmin , Jin, Haifeng , Guo, Changcun , Xie, Huahong , Yan, Kun , Li, Xiaohuai , Shen, Qing , Qiao, Taidong , Chen, Guanglei , Chai, Na , Zhao, Lina , Dong, Qingchuan , Zheng, Yan , Liu, Jie , Fan, Daiming
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/19081179
Zum Text:
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recordid: cdi_crossref_primary_10_1016_j_canlet_2008_10_044
title: CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
format: Article
creator:
  • He, Lijie
  • Wang, Hanmin
  • Jin, Haifeng
  • Guo, Changcun
  • Xie, Huahong
  • Yan, Kun
  • Li, Xiaohuai
  • Shen, Qing
  • Qiao, Taidong
  • Chen, Guanglei
  • Chai, Na
  • Zhao, Lina
  • Dong, Qingchuan
  • Zheng, Yan
  • Liu, Jie
  • Fan, Daiming
subjects:
  • Biomarkers, Tumor - analysis
  • Blotting, Western
  • Carcinoma, Renal Cell - genetics
  • Carcinoma, Renal Cell - metabolism
  • Cell culture
  • Cell cycle
  • Cell growth
  • Cell Proliferation
  • CIAPIN1
  • Clear cell renal cell carcinoma
  • Cloning
  • Cyclin-dependent kinases
  • Experiments
  • G1/S
  • Gene Expression
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins - genetics
  • Intracellular Signaling Peptides and Proteins - metabolism
  • Kidney cancer
  • Kidney Neoplasms - genetics
  • Kidney Neoplasms - metabolism
  • Kinases
  • Pediatrics
  • Phosphorylation
  • Proliferation
  • Proteins
  • Rodents
  • Tumors
  • VEGF
ispartof: Cancer letters, 2008, Vol.276 (1), p.88-94
description: Abstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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creatorHe, Lijie ; Wang, Hanmin ; Jin, Haifeng ; Guo, Changcun ; Xie, Huahong ; Yan, Kun ; Li, Xiaohuai ; Shen, Qing ; Qiao, Taidong ; Chen, Guanglei ; Chai, Na ; Zhao, Lina ; Dong, Qingchuan ; Zheng, Yan ; Liu, Jie ; Fan, Daiming
creatorcontribHe, Lijie ; Wang, Hanmin ; Jin, Haifeng ; Guo, Changcun ; Xie, Huahong ; Yan, Kun ; Li, Xiaohuai ; Shen, Qing ; Qiao, Taidong ; Chen, Guanglei ; Chai, Na ; Zhao, Lina ; Dong, Qingchuan ; Zheng, Yan ; Liu, Jie ; Fan, Daiming
descriptionAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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subjectBiomarkers, Tumor - analysis ; Blotting, Western ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - metabolism ; Cell culture ; Cell cycle ; Cell growth ; Cell Proliferation ; CIAPIN1 ; Clear cell renal cell carcinoma ; Cloning ; Cyclin-dependent kinases ; Experiments ; G1/S ; Gene Expression ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Kidney cancer ; Kidney Neoplasms - genetics ; Kidney Neoplasms - metabolism ; Kinases ; Pediatrics ; Phosphorylation ; Proliferation ; Proteins ; Rodents ; Tumors ; VEGF
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descriptionAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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2Carcinoma, Renal Cell - genetics
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4Cell culture
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6Cell growth
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17Immunohistochemistry
18Intracellular Signaling Peptides and Proteins - genetics
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22Kidney Neoplasms - metabolism
23Kinases
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titleCIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
authorHe, Lijie ; Wang, Hanmin ; Jin, Haifeng ; Guo, Changcun ; Xie, Huahong ; Yan, Kun ; Li, Xiaohuai ; Shen, Qing ; Qiao, Taidong ; Chen, Guanglei ; Chai, Na ; Zhao, Lina ; Dong, Qingchuan ; Zheng, Yan ; Liu, Jie ; Fan, Daiming
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6Cell growth
7Cell Proliferation
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15Hematology, Oncology and Palliative Medicine
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17Immunohistochemistry
18Intracellular Signaling Peptides and Proteins - genetics
19Intracellular Signaling Peptides and Proteins - metabolism
20Kidney cancer
21Kidney Neoplasms - genetics
22Kidney Neoplasms - metabolism
23Kinases
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25Phosphorylation
26Proliferation
27Proteins
28Rodents
29Tumors
30VEGF
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abstractAbstract Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues ( P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
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