schliessen

Filtern

 

Bibliotheken

Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)

Abstract It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent o... Full description

Journal Title: Cancer letters 2009, Vol.285 (2), p.127-133
Main Author: Lin, Song-Shei
Other Authors: Lai, Kuang-Chi , Hsu, Shu-Chun , Yang, Jai-Sing , Kuo, Chao-Lin , Lin, Jing-Pin , Ma, Yi-Shih , Wu, Chih-Chung , Chung, Jing-Gung
Format: Electronic Article Electronic Article
Language: English
Subjects:
R&D
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/19477063
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_crossref_primary_10_1016_j_canlet_2009_04_037
title: Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
format: Article
creator:
  • Lin, Song-Shei
  • Lai, Kuang-Chi
  • Hsu, Shu-Chun
  • Yang, Jai-Sing
  • Kuo, Chao-Lin
  • Lin, Jing-Pin
  • Ma, Yi-Shih
  • Wu, Chih-Chung
  • Chung, Jing-Gung
subjects:
  • A549 cancer cells
  • Angiogenesis
  • Antineoplastic Agents - pharmacology
  • Binding sites
  • Blotting, Western
  • Cancer therapies
  • Cell adhesion & migration
  • Cell culture
  • Cell cycle
  • Cell Line, Tumor
  • Cell Movement - drug effects
  • Curcuma longa
  • Curcumin
  • Curcumin - pharmacology
  • Drug dosages
  • Gene expression
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Invasion
  • Kinases
  • Lung Neoplasms - metabolism
  • Lung Neoplasms - pathology
  • Matrix Metalloproteinase 2 - drug effects
  • Matrix Metalloproteinase 2 - metabolism
  • Matrix Metalloproteinase 9 - drug effects
  • Matrix Metalloproteinase 9 - metabolism
  • Matrix metalloproteinases
  • Matrix Metalloproteinases - drug effects
  • Matrix Metalloproteinases - metabolism
  • Migration
  • Neoplasm Invasiveness - prevention & control
  • Proteins
  • R&D
  • Research & development
  • Signal Transduction - drug effects
  • Vascular endothelial growth factor
  • Vascular Endothelial Growth Factor A - drug effects
  • Vascular Endothelial Growth Factor A - metabolism
ispartof: Cancer letters, 2009, Vol.285 (2), p.127-133
description: Abstract It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. Curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. There is however, no available information to address the effects of curcumin on migration and invasion of human lung cancer cells. The anti-tumor invasion and migration effects of lung cancer cells induced by curcumin were examined. Here, we report that curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro . Our findings suggest that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells. Moreover, this action was involved in the MEKK3, p-ERK signaling pathways resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells. Overall, the above data shows that the anticancer effect of curcumin is also exist for the inhibition of migration and invasion in lung cancer cells.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.632169
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_crossref_primary_10_1016_j_canlet_2009_04_037
sourceformatXML
sourcesystemPC
sourcerecordid21154495
originalsourceidFETCH-LOGICAL-c464t-bfaa817fd62d3e8ed052e197d80811dafd94cae45b586d9f5631098ef1dcbf2c3
addsrcrecordideNqVktGKEzEUhgdR3O7qG4gEBFkvpp7MJDMTL4SltFVY8ELd25AmmTY1k6xJZnVfzOcz0xYW9ka8OoT8_5eT85-ieIVhjgE37_dzKZzVaV4BsDmQOdTtk2KGu7YqW9bB02IGNZCy7mp6VpzHuAcASlr6vDjDjLQtNPWs-LMYgxwH45BxO7MxKaK002gw2yCS8Q4Jp_LVnYjTwfdoNw7CoStKGLKj26LchNQBSW3tZA1-3O4OiBPvZBtECuY3GnQS1vrb4JM2TkRdVocXSnYoNyLK0YqAlk75DLFGWLQO_lfaoZWQyQd0ebNcr969KJ71wkb98lQviu-r5bfFp_L6y_rz4uq6lKQhqdz0QnS47VVTqVp3WgGtNGat6qDDWIleMSKFJnRDu0axnjY1BtbpHiu56StZXxRvj9zc8c9Rx8QHE6e_Cqf9GHmFMSWE0Sx880i492NwuTeOKdCOdRRIVpGjSgYfY9A9vw1mEOGeY-BTqnzPj6nyKVUOhOdUs-31CT5uBq0eTKcYs-DDI6406ZBfCsLYf9E_Hs06D_LO6MCjNDqnqkzQMnHlzf8CpDXOSGF_6HsdHwbBY8WBf53WctpKYAB1lfv_C5BR39g
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1505898504
display
typearticle
titleCurcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
sourceAlma/SFX Local Collection
creatorLin, Song-Shei ; Lai, Kuang-Chi ; Hsu, Shu-Chun ; Yang, Jai-Sing ; Kuo, Chao-Lin ; Lin, Jing-Pin ; Ma, Yi-Shih ; Wu, Chih-Chung ; Chung, Jing-Gung
creatorcontribLin, Song-Shei ; Lai, Kuang-Chi ; Hsu, Shu-Chun ; Yang, Jai-Sing ; Kuo, Chao-Lin ; Lin, Jing-Pin ; Ma, Yi-Shih ; Wu, Chih-Chung ; Chung, Jing-Gung
descriptionAbstract It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. Curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. There is however, no available information to address the effects of curcumin on migration and invasion of human lung cancer cells. The anti-tumor invasion and migration effects of lung cancer cells induced by curcumin were examined. Here, we report that curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro . Our findings suggest that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells. Moreover, this action was involved in the MEKK3, p-ERK signaling pathways resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells. Overall, the above data shows that the anticancer effect of curcumin is also exist for the inhibition of migration and invasion in lung cancer cells.
identifier
0ISSN: 0304-3835
1EISSN: 1872-7980
2DOI: 10.1016/j.canlet.2009.04.037
3PMID: 19477063
languageeng
publisherIreland: Elsevier Ireland Ltd
subjectA549 cancer cells ; Angiogenesis ; Antineoplastic Agents - pharmacology ; Binding sites ; Blotting, Western ; Cancer therapies ; Cell adhesion & migration ; Cell culture ; Cell cycle ; Cell Line, Tumor ; Cell Movement - drug effects ; Curcuma longa ; Curcumin ; Curcumin - pharmacology ; Drug dosages ; Gene expression ; Hematology, Oncology and Palliative Medicine ; Humans ; Invasion ; Kinases ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Matrix Metalloproteinase 2 - drug effects ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - drug effects ; Matrix Metalloproteinase 9 - metabolism ; Matrix metalloproteinases ; Matrix Metalloproteinases - drug effects ; Matrix Metalloproteinases - metabolism ; Migration ; Neoplasm Invasiveness - prevention & control ; Proteins ; R&D ; Research & development ; Signal Transduction - drug effects ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - drug effects ; Vascular Endothelial Growth Factor A - metabolism
ispartofCancer letters, 2009, Vol.285 (2), p.127-133
rights
0Elsevier Ireland Ltd
12009 Elsevier Ireland Ltd
2Copyright Elsevier Limited Nov 28, 2009
lds50peer_reviewed
citedbyFETCH-LOGICAL-c464t-bfaa817fd62d3e8ed052e197d80811dafd94cae45b586d9f5631098ef1dcbf2c3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19477063$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Lin, Song-Shei
1Lai, Kuang-Chi
2Hsu, Shu-Chun
3Yang, Jai-Sing
4Kuo, Chao-Lin
5Lin, Jing-Pin
6Ma, Yi-Shih
7Wu, Chih-Chung
8Chung, Jing-Gung
title
0Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
1Cancer letters
addtitleCancer Lett
descriptionAbstract It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. Curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. There is however, no available information to address the effects of curcumin on migration and invasion of human lung cancer cells. The anti-tumor invasion and migration effects of lung cancer cells induced by curcumin were examined. Here, we report that curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro . Our findings suggest that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells. Moreover, this action was involved in the MEKK3, p-ERK signaling pathways resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells. Overall, the above data shows that the anticancer effect of curcumin is also exist for the inhibition of migration and invasion in lung cancer cells.
subject
0A549 cancer cells
1Angiogenesis
2Antineoplastic Agents - pharmacology
3Binding sites
4Blotting, Western
5Cancer therapies
6Cell adhesion & migration
7Cell culture
8Cell cycle
9Cell Line, Tumor
10Cell Movement - drug effects
11Curcuma longa
12Curcumin
13Curcumin - pharmacology
14Drug dosages
15Gene expression
16Hematology, Oncology and Palliative Medicine
17Humans
18Invasion
19Kinases
20Lung Neoplasms - metabolism
21Lung Neoplasms - pathology
22Matrix Metalloproteinase 2 - drug effects
23Matrix Metalloproteinase 2 - metabolism
24Matrix Metalloproteinase 9 - drug effects
25Matrix Metalloproteinase 9 - metabolism
26Matrix metalloproteinases
27Matrix Metalloproteinases - drug effects
28Matrix Metalloproteinases - metabolism
29Migration
30Neoplasm Invasiveness - prevention & control
31Proteins
32R&D
33Research & development
34Signal Transduction - drug effects
35Vascular endothelial growth factor
36Vascular Endothelial Growth Factor A - drug effects
37Vascular Endothelial Growth Factor A - metabolism
issn
00304-3835
11872-7980
fulltexttrue
rsrctypearticle
creationdate2009
recordtypearticle
recordideNqVktGKEzEUhgdR3O7qG4gEBFkvpp7MJDMTL4SltFVY8ELd25AmmTY1k6xJZnVfzOcz0xYW9ka8OoT8_5eT85-ieIVhjgE37_dzKZzVaV4BsDmQOdTtk2KGu7YqW9bB02IGNZCy7mp6VpzHuAcASlr6vDjDjLQtNPWs-LMYgxwH45BxO7MxKaK002gw2yCS8Q4Jp_LVnYjTwfdoNw7CoStKGLKj26LchNQBSW3tZA1-3O4OiBPvZBtECuY3GnQS1vrb4JM2TkRdVocXSnYoNyLK0YqAlk75DLFGWLQO_lfaoZWQyQd0ebNcr969KJ71wkb98lQviu-r5bfFp_L6y_rz4uq6lKQhqdz0QnS47VVTqVp3WgGtNGat6qDDWIleMSKFJnRDu0axnjY1BtbpHiu56StZXxRvj9zc8c9Rx8QHE6e_Cqf9GHmFMSWE0Sx880i492NwuTeOKdCOdRRIVpGjSgYfY9A9vw1mEOGeY-BTqnzPj6nyKVUOhOdUs-31CT5uBq0eTKcYs-DDI6406ZBfCsLYf9E_Hs06D_LO6MCjNDqnqkzQMnHlzf8CpDXOSGF_6HsdHwbBY8WBf53WctpKYAB1lfv_C5BR39g
startdate2009
enddate2009
creator
0Lin, Song-Shei
1Lai, Kuang-Chi
2Hsu, Shu-Chun
3Yang, Jai-Sing
4Kuo, Chao-Lin
5Lin, Jing-Pin
6Ma, Yi-Shih
7Wu, Chih-Chung
8Chung, Jing-Gung
general
0Elsevier Ireland Ltd
1Elsevier Limited
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97RV
107TO
117U9
127X7
137XB
1488E
1588G
168AO
178C1
188FE
198FH
208FI
218FJ
228FK
238G5
24ABUWG
25AZQEC
26BBNVY
27BENPR
28BHPHI
29DWQXO
30FYUFA
31GHDGH
32GNUQQ
33GUQSH
34H94
35HCIFZ
36K9.
37KB0
38LK8
39M0S
40M1P
41M2M
42M2O
43M7P
44MBDVC
45NAPCQ
46PADUT
47PQEST
48PQQKQ
49PQUKI
50PRINS
51Q9U
527U7
53C1K
sort
creationdate2009
titleCurcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
authorLin, Song-Shei ; Lai, Kuang-Chi ; Hsu, Shu-Chun ; Yang, Jai-Sing ; Kuo, Chao-Lin ; Lin, Jing-Pin ; Ma, Yi-Shih ; Wu, Chih-Chung ; Chung, Jing-Gung
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c464t-bfaa817fd62d3e8ed052e197d80811dafd94cae45b586d9f5631098ef1dcbf2c3
rsrctypearticles
prefilterarticles
languageeng
creationdate2009
topic
0A549 cancer cells
1Angiogenesis
2Antineoplastic Agents - pharmacology
3Binding sites
4Blotting, Western
5Cancer therapies
6Cell adhesion & migration
7Cell culture
8Cell cycle
9Cell Line, Tumor
10Cell Movement - drug effects
11Curcuma longa
12Curcumin
13Curcumin - pharmacology
14Drug dosages
15Gene expression
16Hematology, Oncology and Palliative Medicine
17Humans
18Invasion
19Kinases
20Lung Neoplasms - metabolism
21Lung Neoplasms - pathology
22Matrix Metalloproteinase 2 - drug effects
23Matrix Metalloproteinase 2 - metabolism
24Matrix Metalloproteinase 9 - drug effects
25Matrix Metalloproteinase 9 - metabolism
26Matrix metalloproteinases
27Matrix Metalloproteinases - drug effects
28Matrix Metalloproteinases - metabolism
29Migration
30Neoplasm Invasiveness - prevention & control
31Proteins
32R&D
33Research & development
34Signal Transduction - drug effects
35Vascular endothelial growth factor
36Vascular Endothelial Growth Factor A - drug effects
37Vascular Endothelial Growth Factor A - metabolism
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Lin, Song-Shei
1Lai, Kuang-Chi
2Hsu, Shu-Chun
3Yang, Jai-Sing
4Kuo, Chao-Lin
5Lin, Jing-Pin
6Ma, Yi-Shih
7Wu, Chih-Chung
8Chung, Jing-Gung
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Nursing & Allied Health Database
9Oncogenes and Growth Factors Abstracts
10Virology and AIDS Abstracts
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14Psychology Database (Alumni)
15ProQuest Pharma Collection
16Public Health Database
17ProQuest SciTech Collection
18ProQuest Natural Science Collection
19Hospital Premium Collection
20Hospital Premium Collection (Alumni Edition)
21ProQuest Central (Alumni) (purchase pre-March 2016)
22Research Library (Alumni Edition)
23ProQuest Central (Alumni Edition)
24ProQuest Central Essentials
25Biological Science Collection
26ProQuest Central
27Natural Science Collection
28ProQuest Central Korea
29Health Research Premium Collection
30Health Research Premium Collection (Alumni)
31ProQuest Central Student
32Research Library Prep
33AIDS and Cancer Research Abstracts
34SciTech Premium Collection
35ProQuest Health & Medical Complete (Alumni)
36Nursing & Allied Health Database (Alumni Edition)
37ProQuest Biological Science Collection
38Health & Medical Collection (Alumni Edition)
39Medical Database
40Psychology Database
41Research Library
42Biological Science Database
43Research Library (Corporate)
44Nursing & Allied Health Premium
45Research Library China
46ProQuest One Academic Eastern Edition
47ProQuest One Academic
48ProQuest One Academic UKI Edition
49ProQuest Central China
50ProQuest Central Basic
51Toxicology Abstracts
52Environmental Sciences and Pollution Management
jtitleCancer letters
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Lin, Song-Shei
1Lai, Kuang-Chi
2Hsu, Shu-Chun
3Yang, Jai-Sing
4Kuo, Chao-Lin
5Lin, Jing-Pin
6Ma, Yi-Shih
7Wu, Chih-Chung
8Chung, Jing-Gung
formatjournal
genrearticle
ristypeJOUR
atitleCurcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
jtitleCancer letters
addtitleCancer Lett
date2009
risdate2009
volume285
issue2
spage127
epage133
pages127-133
issn0304-3835
eissn1872-7980
abstractAbstract It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. Curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. There is however, no available information to address the effects of curcumin on migration and invasion of human lung cancer cells. The anti-tumor invasion and migration effects of lung cancer cells induced by curcumin were examined. Here, we report that curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro . Our findings suggest that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells. Moreover, this action was involved in the MEKK3, p-ERK signaling pathways resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells. Overall, the above data shows that the anticancer effect of curcumin is also exist for the inhibition of migration and invasion in lung cancer cells.
copIreland
pubElsevier Ireland Ltd
pmid19477063
doi10.1016/j.canlet.2009.04.037