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Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

Highlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.... Full description

Journal Title: Cancer letters 2015, Vol.368 (1), p.88-96
Main Author: Ma, Ming-zhe
Other Authors: Chen, Gang , Wang, Peng , Lu, Wen-hua , Zhu, Chao-feng , Song, Ming , Yang, Jing , Wen, Shijun , Xu, Rui-hua , Hu, Yumin , Huang, Peng
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
ROS
xCT
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier B.V
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/26254540
Zum Text:
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recordid: cdi_crossref_primary_10_1016_j_canlet_2015_07_031
title: Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
format: Article
creator:
  • Ma, Ming-zhe
  • Chen, Gang
  • Wang, Peng
  • Lu, Wen-hua
  • Zhu, Chao-feng
  • Song, Ming
  • Yang, Jing
  • Wen, Shijun
  • Xu, Rui-hua
  • Hu, Yumin
  • Huang, Peng
subjects:
  • Acetylcysteine
  • Amino Acid Transport System y+ - antagonists & inhibitors
  • Amino Acid Transport System y+ - metabolism
  • Antineoplastic Combined Chemotherapy Protocols - pharmacology
  • Antioxidants
  • Antioxidants - pharmacology
  • Apoptosis
  • Cancer
  • Cancer therapies
  • Cell Proliferation - drug effects
  • Chemosensitization
  • Chemotherapy
  • Cisplatin
  • Cisplatin - pharmacology
  • Colorectal cancer
  • Colorectal carcinoma
  • Colorectal Neoplasms - metabolism
  • Colorectal Neoplasms - pathology
  • Cysteine
  • Cytotoxicity
  • Deoxyribonucleic acid
  • Detoxification
  • DNA
  • DNA damage
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm - drug effects
  • Enzymes
  • Epithelial cells
  • FDA approval
  • Glutathione
  • Glutathione - metabolism
  • HCT116 Cells
  • Hematology, Oncology and Palliative Medicine
  • Histones - metabolism
  • HT29 Cells
  • Humans
  • Inflammation
  • Inflammatory bowel disease
  • Inhibition
  • Intracellular
  • Mortality
  • N-Acetyl-L-cysteine
  • Oxidative Stress - drug effects
  • Platinum
  • Reactive oxygen species
  • Reactive Oxygen Species - metabolism
  • ROS
  • Studies
  • Sulfasalazine
  • Sulfasalazine - pharmacology
  • Tumor cell lines
  • xCT
ispartof: Cancer letters, 2015, Vol.368 (1), p.88-96
description: Highlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleXc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
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creatorMa, Ming-zhe ; Chen, Gang ; Wang, Peng ; Lu, Wen-hua ; Zhu, Chao-feng ; Song, Ming ; Yang, Jing ; Wen, Shijun ; Xu, Rui-hua ; Hu, Yumin ; Huang, Peng
creatorcontribMa, Ming-zhe ; Chen, Gang ; Wang, Peng ; Lu, Wen-hua ; Zhu, Chao-feng ; Song, Ming ; Yang, Jing ; Wen, Shijun ; Xu, Rui-hua ; Hu, Yumin ; Huang, Peng
descriptionHighlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.
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languageeng
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subjectAcetylcysteine ; Amino Acid Transport System y+ - antagonists & inhibitors ; Amino Acid Transport System y+ - metabolism ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Antioxidants ; Antioxidants - pharmacology ; Apoptosis ; Cancer ; Cancer therapies ; Cell Proliferation - drug effects ; Chemosensitization ; Chemotherapy ; Cisplatin ; Cisplatin - pharmacology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Cysteine ; Cytotoxicity ; Deoxyribonucleic acid ; Detoxification ; DNA ; DNA damage ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm - drug effects ; Enzymes ; Epithelial cells ; FDA approval ; Glutathione ; Glutathione - metabolism ; HCT116 Cells ; Hematology, Oncology and Palliative Medicine ; Histones - metabolism ; HT29 Cells ; Humans ; Inflammation ; Inflammatory bowel disease ; Inhibition ; Intracellular ; Mortality ; N-Acetyl-L-cysteine ; Oxidative Stress - drug effects ; Platinum ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; ROS ; Studies ; Sulfasalazine ; Sulfasalazine - pharmacology ; Tumor cell lines ; xCT
ispartofCancer letters, 2015, Vol.368 (1), p.88-96
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0Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
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descriptionHighlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.
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36Inflammation
37Inflammatory bowel disease
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40Mortality
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42Oxidative Stress - drug effects
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abstractHighlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.
copIreland
pubElsevier B.V
pmid26254540
doi10.1016/j.canlet.2015.07.031