Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

Highlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.... Full description

Journal Title:	Cancer letters 2015, Vol.368 (1), p.88-96
Main Author:	Ma, Ming-zhe
Other Authors:	Chen, Gang , Wang, Peng , Lu, Wen-hua , Zhu, Chao-feng , Song, Ming , Yang, Jing , Wen, Shijun , Xu, Rui-hua , Hu, Yumin , Huang, Peng
Format:	Electronic Article
Language:	English
Subjects:	Acetylcysteine Amino Acid Transport System y+ - antagonists & inhibitors Amino Acid Transport System y+ - metabolism Antineoplastic Combined Chemotherapy Protocols - pharmacology Antioxidants Antioxidants - pharmacology Apoptosis Cancer Cancer therapies Cell Proliferation - drug effects Chemosensitization Chemotherapy Cisplatin Cisplatin - pharmacology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cysteine Cytotoxicity Deoxyribonucleic acid Detoxification DNA DNA damage Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Enzymes Epithelial cells FDA approval Glutathione Glutathione - metabolism HCT116 Cells Hematology, Oncology and Palliative Medicine Histones - metabolism HT29 Cells Humans Inflammation Inflammatory bowel disease Inhibition Intracellular Mortality N-Acetyl-L-cysteine Oxidative Stress - drug effects Platinum Reactive oxygen species Reactive Oxygen Species - metabolism ROS Studies Sulfasalazine Sulfasalazine - pharmacology Tumor cell lines xCT
Quelle:	Alma/SFX Local Collection
Publisher:	Ireland: Elsevier B.V
ID:	ISSN: 0304-3835
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26254540
Zum Text:

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title:	Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
format:	Article
creator:	Ma, Ming-zhe Chen, Gang Wang, Peng Lu, Wen-hua Zhu, Chao-feng Song, Ming Yang, Jing Wen, Shijun Xu, Rui-hua Hu, Yumin Huang, Peng
subjects:	Acetylcysteine Amino Acid Transport System y+ - antagonists & inhibitors Amino Acid Transport System y+ - metabolism Antineoplastic Combined Chemotherapy Protocols - pharmacology Antioxidants Antioxidants - pharmacology Apoptosis Cancer Cancer therapies Cell Proliferation - drug effects Chemosensitization Chemotherapy Cisplatin Cisplatin - pharmacology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cysteine Cytotoxicity Deoxyribonucleic acid Detoxification DNA DNA damage Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Enzymes Epithelial cells FDA approval Glutathione Glutathione - metabolism HCT116 Cells Hematology, Oncology and Palliative Medicine Histones - metabolism HT29 Cells Humans Inflammation Inflammatory bowel disease Inhibition Intracellular Mortality N-Acetyl-L-cysteine Oxidative Stress - drug effects Platinum Reactive oxygen species Reactive Oxygen Species - metabolism ROS Studies Sulfasalazine Sulfasalazine - pharmacology Tumor cell lines xCT
ispartof:	Cancer letters, 2015, Vol.368 (1), p.88-96
description:	Highlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in CRC. • SSZ and CDDP cause synergistic cytotoxic effect in CRC cells. • SSZ enhances cellular platinum level and DNA damage induced by CDDP.
language:	eng
source:	Alma/SFX Local Collection
identifier:	ISSN: 0304-3835
fulltext:	fulltext
issn:	0304-3835 1872-7980
url:	Link

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Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

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Ma, Ming-zhe ; Chen, Gang ; Wang, Peng ; Lu, Wen-hua ; Zhu, Chao-feng ; Song, Ming ; Yang, Jing ; Wen, Shijun ; Xu, Rui-hua ; Hu, Yumin ; Huang, Peng

creatorcontrib

Ma, Ming-zhe ; Chen, Gang ; Wang, Peng ; Lu, Wen-hua ; Zhu, Chao-feng ; Song, Ming ; Yang, Jing ; Wen, Shijun ; Xu, Rui-hua ; Hu, Yumin ; Huang, Peng

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3	PMID: 26254540

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Ireland: Elsevier B.V

subject

Acetylcysteine ; Amino Acid Transport System y+ - antagonists & inhibitors ; Amino Acid Transport System y+ - metabolism ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Antioxidants ; Antioxidants - pharmacology ; Apoptosis ; Cancer ; Cancer therapies ; Cell Proliferation - drug effects ; Chemosensitization ; Chemotherapy ; Cisplatin ; Cisplatin - pharmacology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Cysteine ; Cytotoxicity ; Deoxyribonucleic acid ; Detoxification ; DNA ; DNA damage ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm - drug effects ; Enzymes ; Epithelial cells ; FDA approval ; Glutathione ; Glutathione - metabolism ; HCT116 Cells ; Hematology, Oncology and Palliative Medicine ; Histones - metabolism ; HT29 Cells ; Humans ; Inflammation ; Inflammatory bowel disease ; Inhibition ; Intracellular ; Mortality ; N-Acetyl-L-cysteine ; Oxidative Stress - drug effects ; Platinum ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; ROS ; Studies ; Sulfasalazine ; Sulfasalazine - pharmacology ; Tumor cell lines ; xCT

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Cancer letters, 2015, Vol.368 (1), p.88-96

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creationdate	2015
title	Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
author	Ma, Ming-zhe ; Chen, Gang ; Wang, Peng ; Lu, Wen-hua ; Zhu, Chao-feng ; Song, Ming ; Yang, Jing ; Wen, Shijun ; Xu, Rui-hua ; Hu, Yumin ; Huang, Peng

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37	Inflammatory bowel disease
38	Inhibition
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40	Mortality
41	N-Acetyl-L-cysteine
42	Oxidative Stress - drug effects
43	Platinum
44	Reactive oxygen species
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46	ROS
47	Studies
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Cancer letters

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2	Wang, Peng
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Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

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Cancer letters

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Cancer Lett

date

2015

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volume

368

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88-96

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0304-3835

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1872-7980

abstract

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Ireland

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Elsevier B.V

pmid

26254540

doi

10.1016/j.canlet.2015.07.031

Suche

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Bibliotheken

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism