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Hormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda

Hormonal contraceptives have been associated with increased risk of HIV acquisition. The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10... Full description

Journal Title: AIDS (London) 2003, Vol.17 (2), p.233-240
Main Author: KIDDUGAVU, Mohammed
Other Authors: MAKUMBI, Fred , WAWER, Maria J , SERWADDA, David , SEWANKAMBO, Nelson K , WABWIRE-MANGEN, Fred , LUTALO, Tom , MEEHAN, Mary , XIANBIN , GRAY, Ronald H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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recordid: cdi_crossref_primary_10_1097_00002030_200301240_00014
title: Hormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda
format: Article
creator:
  • KIDDUGAVU, Mohammed
  • MAKUMBI, Fred
  • WAWER, Maria J
  • SERWADDA, David
  • SEWANKAMBO, Nelson K
  • WABWIRE-MANGEN, Fred
  • LUTALO, Tom
  • MEEHAN, Mary
  • XIANBIN
  • GRAY, Ronald H
subjects:
  • Adolescent
  • Adult
  • Age Distribution
  • Biological and medical sciences
  • Condoms - statistics & numerical data
  • Contraception Behavior
  • Contraceptive Agents, Female - administration & dosage
  • Contraceptive Agents, Female - adverse effects
  • Developing Countries
  • Female
  • HIV Infections - epidemiology
  • HIV Infections - transmission
  • HIV-1
  • Human viral diseases
  • Humans
  • Incidence
  • Infectious diseases
  • Medical sciences
  • Middle Aged
  • Poisson Distribution
  • Progesterone Congeners - administration & dosage
  • Progesterone Congeners - adverse effects
  • Risk Factors
  • Rural Health - statistics & numerical data
  • Sexual Behavior - statistics & numerical data
  • Tropical medicine
  • Uganda - epidemiology
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
ispartof: AIDS (London), 2003, Vol.17 (2), p.233-240
description: Hormonal contraceptives have been associated with increased risk of HIV acquisition. The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10 month intervals between 1994 and 1999. Information on demographic and sociobehavioral characteristics, use of hormonal contraception (pill and injectable methods), condoms and the number of sexual partners was obtained by home-based interview. HIV incidence rate ratios (IRR) and 95% confidence intervals (CI) associated with hormonal contraception were estimated by multivariate Poisson regression after adjustment for age, condom use, number of sexual partners, marital status, education and history of genital ulcer disease. At one or more interviews, 16.6% of women reported use of hormonal contraceptives and 23.0% reported condom use. HIV incidence was 2.3/100 person-years in hormonal contraceptive users compared with 1.5/100 person-years in non-hormonal contraceptive users (unadjusted IRR, 1.56; 95% CI, 1.00-2.33). After multivariate adjustment, the IRR associated with hormonal contraceptives was reduced to 0.94 (95% CI, 0.53-1.64). The adjusted IRR was 1.12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95%CI, 0.41-1.72) with injectable methods. Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleHormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda
creatorKIDDUGAVU, Mohammed ; MAKUMBI, Fred ; WAWER, Maria J ; SERWADDA, David ; SEWANKAMBO, Nelson K ; WABWIRE-MANGEN, Fred ; LUTALO, Tom ; MEEHAN, Mary ; XIANBIN ; GRAY, Ronald H
creatorcontribKIDDUGAVU, Mohammed ; MAKUMBI, Fred ; WAWER, Maria J ; SERWADDA, David ; SEWANKAMBO, Nelson K ; WABWIRE-MANGEN, Fred ; LUTALO, Tom ; MEEHAN, Mary ; XIANBIN ; GRAY, Ronald H ; Rakai Project Study Group
descriptionHormonal contraceptives have been associated with increased risk of HIV acquisition. The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10 month intervals between 1994 and 1999. Information on demographic and sociobehavioral characteristics, use of hormonal contraception (pill and injectable methods), condoms and the number of sexual partners was obtained by home-based interview. HIV incidence rate ratios (IRR) and 95% confidence intervals (CI) associated with hormonal contraception were estimated by multivariate Poisson regression after adjustment for age, condom use, number of sexual partners, marital status, education and history of genital ulcer disease. At one or more interviews, 16.6% of women reported use of hormonal contraceptives and 23.0% reported condom use. HIV incidence was 2.3/100 person-years in hormonal contraceptive users compared with 1.5/100 person-years in non-hormonal contraceptive users (unadjusted IRR, 1.56; 95% CI, 1.00-2.33). After multivariate adjustment, the IRR associated with hormonal contraceptives was reduced to 0.94 (95% CI, 0.53-1.64). The adjusted IRR was 1.12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95%CI, 0.41-1.72) with injectable methods. Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding.
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subjectAdolescent ; Adult ; Age Distribution ; Biological and medical sciences ; Condoms - statistics & numerical data ; Contraception Behavior ; Contraceptive Agents, Female - administration & dosage ; Contraceptive Agents, Female - adverse effects ; Developing Countries ; Female ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV-1 ; Human viral diseases ; Humans ; Incidence ; Infectious diseases ; Medical sciences ; Middle Aged ; Poisson Distribution ; Progesterone Congeners - administration & dosage ; Progesterone Congeners - adverse effects ; Risk Factors ; Rural Health - statistics & numerical data ; Sexual Behavior - statistics & numerical data ; Tropical medicine ; Uganda - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
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descriptionHormonal contraceptives have been associated with increased risk of HIV acquisition. The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10 month intervals between 1994 and 1999. Information on demographic and sociobehavioral characteristics, use of hormonal contraception (pill and injectable methods), condoms and the number of sexual partners was obtained by home-based interview. HIV incidence rate ratios (IRR) and 95% confidence intervals (CI) associated with hormonal contraception were estimated by multivariate Poisson regression after adjustment for age, condom use, number of sexual partners, marital status, education and history of genital ulcer disease. At one or more interviews, 16.6% of women reported use of hormonal contraceptives and 23.0% reported condom use. HIV incidence was 2.3/100 person-years in hormonal contraceptive users compared with 1.5/100 person-years in non-hormonal contraceptive users (unadjusted IRR, 1.56; 95% CI, 1.00-2.33). After multivariate adjustment, the IRR associated with hormonal contraceptives was reduced to 0.94 (95% CI, 0.53-1.64). The adjusted IRR was 1.12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95%CI, 0.41-1.72) with injectable methods. Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding.
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5Contraception Behavior
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10HIV Infections - epidemiology
11HIV Infections - transmission
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20Progesterone Congeners - administration & dosage
21Progesterone Congeners - adverse effects
22Risk Factors
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24Sexual Behavior - statistics & numerical data
25Tropical medicine
26Uganda - epidemiology
27Viral diseases
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titleHormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda
authorKIDDUGAVU, Mohammed ; MAKUMBI, Fred ; WAWER, Maria J ; SERWADDA, David ; SEWANKAMBO, Nelson K ; WABWIRE-MANGEN, Fred ; LUTALO, Tom ; MEEHAN, Mary ; XIANBIN ; GRAY, Ronald H
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1Adult
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abstractHormonal contraceptives have been associated with increased risk of HIV acquisition. The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10 month intervals between 1994 and 1999. Information on demographic and sociobehavioral characteristics, use of hormonal contraception (pill and injectable methods), condoms and the number of sexual partners was obtained by home-based interview. HIV incidence rate ratios (IRR) and 95% confidence intervals (CI) associated with hormonal contraception were estimated by multivariate Poisson regression after adjustment for age, condom use, number of sexual partners, marital status, education and history of genital ulcer disease. At one or more interviews, 16.6% of women reported use of hormonal contraceptives and 23.0% reported condom use. HIV incidence was 2.3/100 person-years in hormonal contraceptive users compared with 1.5/100 person-years in non-hormonal contraceptive users (unadjusted IRR, 1.56; 95% CI, 1.00-2.33). After multivariate adjustment, the IRR associated with hormonal contraceptives was reduced to 0.94 (95% CI, 0.53-1.64). The adjusted IRR was 1.12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95%CI, 0.41-1.72) with injectable methods. Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding.
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pubLippincott Williams & Wilkins
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doi10.1097/00002030-200301240-00014