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A bacterial cell to cell signal in the lungs of cystic fibrosis patients

Abstract Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of mortality in cystic fibrosis (CF) patients. This bacterium has numerous genes controlled by cell to cell signaling, which occurs through a complex circuitry of interconnected regulatory systems. One of the signals... Full description

Journal Title: FEMS microbiology letters 2002-09-01, Vol.215 (1), p.41-46
Main Author: Collier, David N
Other Authors: Anderson, Lisa , McKnight, Susan L , Noah, Terry L , Knowles, Michael , Boucher, Richard , Schwab, Ute , Gilligan, Peter , Pesci, Everett C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Oxford, UK: Blackwell Publishing Ltd
ID: ISSN: 0378-1097
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recordid: cdi_crossref_primary_10_1111_j_1574_6968_2002_tb11367_x
title: A bacterial cell to cell signal in the lungs of cystic fibrosis patients
format: Article
creator:
  • Collier, David N
  • Anderson, Lisa
  • McKnight, Susan L
  • Noah, Terry L
  • Knowles, Michael
  • Boucher, Richard
  • Schwab, Ute
  • Gilligan, Peter
  • Pesci, Everett C
subjects:
  • Alveoli
  • Bronchoalveolar lavage
  • Bronchus
  • Circuits
  • Cystic fibrosis
  • Infections
  • Insects
  • Lung transplantation
  • Lungs
  • Opportunist infection
  • Pathogens
  • Pseudomonas aeruginosa
  • Pseudomonas Quinolone Signal
  • Quorum sensing
  • Sputum
  • Syngeneic grafts
  • Virulence
  • Virulence factors
ispartof: FEMS microbiology letters, 2002-09-01, Vol.215 (1), p.41-46
description: Abstract Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of mortality in cystic fibrosis (CF) patients. This bacterium has numerous genes controlled by cell to cell signaling, which occurs through a complex circuitry of interconnected regulatory systems. One of the signals is the Pseudomonas Quinolone Signal (PQS), which was identified as 2-heptyl-3-hydroxy-4-quinolone. This intercellular signal controls the expression of multiple virulence factors and is required for virulence in an insect model of P. aeruginosa infection. Previous studies have implied that the intercellular signals of P. aeruginosa are important for human disease, and our goal was to determine whether PQS was produced during human infections. In this report, three types of samples from CF patients infected with P. aeruginosa were analyzed for the presence of PQS. Sputum, bronchoalveolar lavage fluid, and mucopurulent fluid from distal airways of end-stage lungs removed at transplant, all contained PQS, indicating that this cell to cell signal is produced in vivo by P. aeruginosa infecting the lungs of CF patients.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0378-1097
fulltext: fulltext
issn:
  • 0378-1097
  • 1574-6968
url: Link


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descriptionAbstract Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of mortality in cystic fibrosis (CF) patients. This bacterium has numerous genes controlled by cell to cell signaling, which occurs through a complex circuitry of interconnected regulatory systems. One of the signals is the Pseudomonas Quinolone Signal (PQS), which was identified as 2-heptyl-3-hydroxy-4-quinolone. This intercellular signal controls the expression of multiple virulence factors and is required for virulence in an insect model of P. aeruginosa infection. Previous studies have implied that the intercellular signals of P. aeruginosa are important for human disease, and our goal was to determine whether PQS was produced during human infections. In this report, three types of samples from CF patients infected with P. aeruginosa were analyzed for the presence of PQS. Sputum, bronchoalveolar lavage fluid, and mucopurulent fluid from distal airways of end-stage lungs removed at transplant, all contained PQS, indicating that this cell to cell signal is produced in vivo by P. aeruginosa infecting the lungs of CF patients.
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subjectAlveoli ; Bronchoalveolar lavage ; Bronchus ; Circuits ; Cystic fibrosis ; Infections ; Insects ; Lung transplantation ; Lungs ; Opportunist infection ; Pathogens ; Pseudomonas aeruginosa ; Pseudomonas Quinolone Signal ; Quorum sensing ; Sputum ; Syngeneic grafts ; Virulence ; Virulence factors
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atitleA bacterial cell to cell signal in the lungs of cystic fibrosis patients
jtitleFEMS microbiology letters
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issn0378-1097
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abstractAbstract Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of mortality in cystic fibrosis (CF) patients. This bacterium has numerous genes controlled by cell to cell signaling, which occurs through a complex circuitry of interconnected regulatory systems. One of the signals is the Pseudomonas Quinolone Signal (PQS), which was identified as 2-heptyl-3-hydroxy-4-quinolone. This intercellular signal controls the expression of multiple virulence factors and is required for virulence in an insect model of P. aeruginosa infection. Previous studies have implied that the intercellular signals of P. aeruginosa are important for human disease, and our goal was to determine whether PQS was produced during human infections. In this report, three types of samples from CF patients infected with P. aeruginosa were analyzed for the presence of PQS. Sputum, bronchoalveolar lavage fluid, and mucopurulent fluid from distal airways of end-stage lungs removed at transplant, all contained PQS, indicating that this cell to cell signal is produced in vivo by P. aeruginosa infecting the lungs of CF patients.
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