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Fat and Beyond: The Diverse Biology of PPARγ

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARγ was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARγ inclu... Full description

Journal Title: Annual review of biochemistry 2008, Vol.77 (1), p.289-312
Main Author: Tontonoz, Peter
Other Authors: Spiegelman, Bruce M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Annual Reviews
ID: ISSN: 0066-4154
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recordid: cdi_crossref_primary_10_1146_annurev_biochem_77_061307_091829
title: Fat and Beyond: The Diverse Biology of PPARγ
format: Article
creator:
  • Tontonoz, Peter
  • Spiegelman, Bruce M
subjects:
  • adipocyte
  • inflammation
  • insulin sensitivity
  • macrophage
  • metabolism
  • nuclear receptor
  • thiazolidindione
ispartof: Annual review of biochemistry, 2008, Vol.77 (1), p.289-312
description: The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARγ was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARγ improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARγ signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARγ with an eye toward the expanding therapeutic potential of PPARγ agonist drugs.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4154
fulltext: fulltext
issn:
  • 0066-4154
  • 1545-4509
url: Link


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descriptionThe nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARγ was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARγ improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARγ signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARγ with an eye toward the expanding therapeutic potential of PPARγ agonist drugs.
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abstractThe nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARγ was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARγ improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARγ signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARγ with an eye toward the expanding therapeutic potential of PPARγ agonist drugs.
pubAnnual Reviews
doi10.1146/annurev.biochem.77.061307.091829