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A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells

Background: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic int... Full description

Journal Title: Annals of nutrition and metabolism 2011-01-01, Vol.58 (2), p.133-140
Main Author: Radler, Ulla
Other Authors: Stangl, Herbert , Lechner, Sigrid , Lienbacher, Gerhard , Krepp, Rainer , Zeller, Eduard , Brachinger, Martin , Eller-Berndl, Doris , Fischer, Andreas , Anzur, Christian , Schoerg, Gerhard , Mascher, Daniel , Laschan, Claudia , Anderwald, Christian , Lohninger, Alfred
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 0250-6807
Link: https://www.ncbi.nlm.nih.gov/pubmed/21540583
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recordid: cdi_crossref_primary_10_1159_000327150
title: A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
format: Article
creator:
  • Radler, Ulla
  • Stangl, Herbert
  • Lechner, Sigrid
  • Lienbacher, Gerhard
  • Krepp, Rainer
  • Zeller, Eduard
  • Brachinger, Martin
  • Eller-Berndl, Doris
  • Fischer, Andreas
  • Anzur, Christian
  • Schoerg, Gerhard
  • Mascher, Daniel
  • Laschan, Claudia
  • Anderwald, Christian
  • Lohninger, Alfred
subjects:
  • Adult
  • Cardiovascular diseases
  • Carnitine
  • Carnitine - administration & dosage
  • Carnitine - metabolism
  • Carnitine - therapeutic use
  • Cell culture
  • Diet
  • Dietary supplements
  • Dietetics
  • Double-Blind Method
  • Enzymes
  • Fatty acids
  • Fatty Acids - metabolism
  • Fatty Acids, Omega-3 - administration & dosage
  • Fatty Acids, Omega-3 - metabolism
  • Fatty Acids, Omega-3 - therapeutic use
  • Female
  • Flavonoids - administration & dosage
  • Flavonoids - metabolism
  • Flavonoids - therapeutic use
  • Functional Food - analysis
  • Gene expression
  • Hep G2 Cells
  • Hepatocytes - metabolism
  • Humans
  • Hyperlipidemia
  • Hyperlipidemias - blood
  • Hyperlipidemias - diet therapy
  • Hyperlipidemias - metabolism
  • Hypolipidemic Agents - administration & dosage
  • Hypolipidemic Agents - metabolism
  • L-Carnitine
  • Leukocytes, Mononuclear - metabolism
  • Lipids
  • Lipids - blood
  • Male
  • Metabolic disorders
  • Middle Aged
  • Obesity
  • organic cation transporter
  • Original Paper
  • Overweight - complications
  • Oxidation
  • Oxidation-Reduction
  • Peripheral blood mononuclear cells
  • Phenols - administration & dosage
  • Phenols - metabolism
  • Phenols - therapeutic use
  • Plasma
  • Polyphenols
  • Polyunsaturated fatty acids
  • PPAR alpha - genetics
  • PPAR alpha - metabolism
  • RNA, Messenger - metabolism
  • Up-Regulation
ispartof: Annals of nutrition and metabolism, 2011-01-01, Vol.58 (2), p.133-140
description: Background: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested. Subjects and Methods: In a prospective placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs, polyphenols and L-carnitine (PPC) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt. The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells (PBMCs) and HepG2 cells were evaluated. Results: PPC consumption led to significantly reduced plasma free fatty acid (–29%) and triglyceride (–24%) concentrations (each p < 0.05). PPC application increased significantly peroxisome proliferator-activated receptor α (PPARα) mRNA abundances and those of PPARα target genes (carnitine palmitoyltransferases-1, CPT1A and CPT1B, carnitine acetyltransferase and organic cation transporter 2; each p < 0.05) in PBMCs. In controls, plasma lipid levels and PBMC gene expression did not change. These findings were substantiated by the results of cell culture experiments in HepG2 cells. Conclusion: Supplementation of PPC had marked lipid-lowering effects and PBMC gene expression profiles seemed to reflect nutrition-related metabolic changes.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0250-6807
fulltext: fulltext
issn:
  • 0250-6807
  • 1421-9697
url: Link


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titleA Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
sourceAlma/SFX Local Collection
creatorRadler, Ulla ; Stangl, Herbert ; Lechner, Sigrid ; Lienbacher, Gerhard ; Krepp, Rainer ; Zeller, Eduard ; Brachinger, Martin ; Eller-Berndl, Doris ; Fischer, Andreas ; Anzur, Christian ; Schoerg, Gerhard ; Mascher, Daniel ; Laschan, Claudia ; Anderwald, Christian ; Lohninger, Alfred
creatorcontribRadler, Ulla ; Stangl, Herbert ; Lechner, Sigrid ; Lienbacher, Gerhard ; Krepp, Rainer ; Zeller, Eduard ; Brachinger, Martin ; Eller-Berndl, Doris ; Fischer, Andreas ; Anzur, Christian ; Schoerg, Gerhard ; Mascher, Daniel ; Laschan, Claudia ; Anderwald, Christian ; Lohninger, Alfred
descriptionBackground: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested. Subjects and Methods: In a prospective placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs, polyphenols and L-carnitine (PPC) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt. The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells (PBMCs) and HepG2 cells were evaluated. Results: PPC consumption led to significantly reduced plasma free fatty acid (–29%) and triglyceride (–24%) concentrations (each p < 0.05). PPC application increased significantly peroxisome proliferator-activated receptor α (PPARα) mRNA abundances and those of PPARα target genes (carnitine palmitoyltransferases-1, CPT1A and CPT1B, carnitine acetyltransferase and organic cation transporter 2; each p < 0.05) in PBMCs. In controls, plasma lipid levels and PBMC gene expression did not change. These findings were substantiated by the results of cell culture experiments in HepG2 cells. Conclusion: Supplementation of PPC had marked lipid-lowering effects and PBMC gene expression profiles seemed to reflect nutrition-related metabolic changes.
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1EISSN: 1421-9697
2DOI: 10.1159/000327150
3PMID: 21540583
languageeng
publisherBasel, Switzerland: S. Karger AG
subjectAdult ; Cardiovascular diseases ; Carnitine ; Carnitine - administration & dosage ; Carnitine - metabolism ; Carnitine - therapeutic use ; Cell culture ; Diet ; Dietary supplements ; Dietetics ; Double-Blind Method ; Enzymes ; Fatty acids ; Fatty Acids - metabolism ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Flavonoids - administration & dosage ; Flavonoids - metabolism ; Flavonoids - therapeutic use ; Functional Food - analysis ; Gene expression ; Hep G2 Cells ; Hepatocytes - metabolism ; Humans ; Hyperlipidemia ; Hyperlipidemias - blood ; Hyperlipidemias - diet therapy ; Hyperlipidemias - metabolism ; Hypolipidemic Agents - administration & dosage ; Hypolipidemic Agents - metabolism ; L-Carnitine ; Leukocytes, Mononuclear - metabolism ; Lipids ; Lipids - blood ; Male ; Metabolic disorders ; Middle Aged ; Obesity ; organic cation transporter ; Original Paper ; Overweight - complications ; Oxidation ; Oxidation-Reduction ; Peripheral blood mononuclear cells ; Phenols - administration & dosage ; Phenols - metabolism ; Phenols - therapeutic use ; Plasma ; Polyphenols ; Polyunsaturated fatty acids ; PPAR alpha - genetics ; PPAR alpha - metabolism ; RNA, Messenger - metabolism ; Up-Regulation
ispartofAnnals of nutrition and metabolism, 2011-01-01, Vol.58 (2), p.133-140
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12011 S. Karger AG, Basel
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0Radler, Ulla
1Stangl, Herbert
2Lechner, Sigrid
3Lienbacher, Gerhard
4Krepp, Rainer
5Zeller, Eduard
6Brachinger, Martin
7Eller-Berndl, Doris
8Fischer, Andreas
9Anzur, Christian
10Schoerg, Gerhard
11Mascher, Daniel
12Laschan, Claudia
13Anderwald, Christian
14Lohninger, Alfred
title
0A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
1Annals of nutrition and metabolism
addtitleAnn Nutr Metab
descriptionBackground: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested. Subjects and Methods: In a prospective placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs, polyphenols and L-carnitine (PPC) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt. The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells (PBMCs) and HepG2 cells were evaluated. Results: PPC consumption led to significantly reduced plasma free fatty acid (–29%) and triglyceride (–24%) concentrations (each p < 0.05). PPC application increased significantly peroxisome proliferator-activated receptor α (PPARα) mRNA abundances and those of PPARα target genes (carnitine palmitoyltransferases-1, CPT1A and CPT1B, carnitine acetyltransferase and organic cation transporter 2; each p < 0.05) in PBMCs. In controls, plasma lipid levels and PBMC gene expression did not change. These findings were substantiated by the results of cell culture experiments in HepG2 cells. Conclusion: Supplementation of PPC had marked lipid-lowering effects and PBMC gene expression profiles seemed to reflect nutrition-related metabolic changes.
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1Cardiovascular diseases
2Carnitine
3Carnitine - administration & dosage
4Carnitine - metabolism
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6Cell culture
7Diet
8Dietary supplements
9Dietetics
10Double-Blind Method
11Enzymes
12Fatty acids
13Fatty Acids - metabolism
14Fatty Acids, Omega-3 - administration & dosage
15Fatty Acids, Omega-3 - metabolism
16Fatty Acids, Omega-3 - therapeutic use
17Female
18Flavonoids - administration & dosage
19Flavonoids - metabolism
20Flavonoids - therapeutic use
21Functional Food - analysis
22Gene expression
23Hep G2 Cells
24Hepatocytes - metabolism
25Humans
26Hyperlipidemia
27Hyperlipidemias - blood
28Hyperlipidemias - diet therapy
29Hyperlipidemias - metabolism
30Hypolipidemic Agents - administration & dosage
31Hypolipidemic Agents - metabolism
32L-Carnitine
33Leukocytes, Mononuclear - metabolism
34Lipids
35Lipids - blood
36Male
37Metabolic disorders
38Middle Aged
39Obesity
40organic cation transporter
41Original Paper
42Overweight - complications
43Oxidation
44Oxidation-Reduction
45Peripheral blood mononuclear cells
46Phenols - administration & dosage
47Phenols - metabolism
48Phenols - therapeutic use
49Plasma
50Polyphenols
51Polyunsaturated fatty acids
52PPAR alpha - genetics
53PPAR alpha - metabolism
54RNA, Messenger - metabolism
55Up-Regulation
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titleA Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
authorRadler, Ulla ; Stangl, Herbert ; Lechner, Sigrid ; Lienbacher, Gerhard ; Krepp, Rainer ; Zeller, Eduard ; Brachinger, Martin ; Eller-Berndl, Doris ; Fischer, Andreas ; Anzur, Christian ; Schoerg, Gerhard ; Mascher, Daniel ; Laschan, Claudia ; Anderwald, Christian ; Lohninger, Alfred
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1Cardiovascular diseases
2Carnitine
3Carnitine - administration & dosage
4Carnitine - metabolism
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6Cell culture
7Diet
8Dietary supplements
9Dietetics
10Double-Blind Method
11Enzymes
12Fatty acids
13Fatty Acids - metabolism
14Fatty Acids, Omega-3 - administration & dosage
15Fatty Acids, Omega-3 - metabolism
16Fatty Acids, Omega-3 - therapeutic use
17Female
18Flavonoids - administration & dosage
19Flavonoids - metabolism
20Flavonoids - therapeutic use
21Functional Food - analysis
22Gene expression
23Hep G2 Cells
24Hepatocytes - metabolism
25Humans
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29Hyperlipidemias - metabolism
30Hypolipidemic Agents - administration & dosage
31Hypolipidemic Agents - metabolism
32L-Carnitine
33Leukocytes, Mononuclear - metabolism
34Lipids
35Lipids - blood
36Male
37Metabolic disorders
38Middle Aged
39Obesity
40organic cation transporter
41Original Paper
42Overweight - complications
43Oxidation
44Oxidation-Reduction
45Peripheral blood mononuclear cells
46Phenols - administration & dosage
47Phenols - metabolism
48Phenols - therapeutic use
49Plasma
50Polyphenols
51Polyunsaturated fatty acids
52PPAR alpha - genetics
53PPAR alpha - metabolism
54RNA, Messenger - metabolism
55Up-Regulation
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atitleA Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
jtitleAnnals of nutrition and metabolism
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issn0250-6807
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abstractBackground: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested. Subjects and Methods: In a prospective placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs, polyphenols and L-carnitine (PPC) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt. The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells (PBMCs) and HepG2 cells were evaluated. Results: PPC consumption led to significantly reduced plasma free fatty acid (–29%) and triglyceride (–24%) concentrations (each p < 0.05). PPC application increased significantly peroxisome proliferator-activated receptor α (PPARα) mRNA abundances and those of PPARα target genes (carnitine palmitoyltransferases-1, CPT1A and CPT1B, carnitine acetyltransferase and organic cation transporter 2; each p < 0.05) in PBMCs. In controls, plasma lipid levels and PBMC gene expression did not change. These findings were substantiated by the results of cell culture experiments in HepG2 cells. Conclusion: Supplementation of PPC had marked lipid-lowering effects and PBMC gene expression profiles seemed to reflect nutrition-related metabolic changes.
copBasel, Switzerland
pubS. Karger AG
pmid21540583
doi10.1159/000327150
tpages8