A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
| Journal Title: | Annals of nutrition and metabolism 2011-01-01, Vol.58 (2), p.133-140 |
| Main Author: | Radler, Ulla |
| Other Authors: | Stangl, Herbert , Lechner, Sigrid , Lienbacher, Gerhard , Krepp, Rainer , Zeller, Eduard , Brachinger, Martin , Eller-Berndl, Doris , Fischer, Andreas , Anzur, Christian , Schoerg, Gerhard , Mascher, Daniel , Laschan, Claudia , Anderwald, Christian , Lohninger, Alfred |
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 Electronic Article
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| Language: |
English |
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| Quelle: | Alma/SFX Local Collection |
| Publisher: | Basel, Switzerland: S. Karger AG |
| ID: | ISSN: 0250-6807 |
| Link: | https://www.ncbi.nlm.nih.gov/pubmed/21540583 |
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| recordid: | cdi_crossref_primary_10_1159_000327150 |
| title: | A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells |
| format: | Article |
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| ispartof: | Annals of nutrition and metabolism, 2011-01-01, Vol.58 (2), p.133-140 |
| description: | Background: Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. Nutritional supplements, e.g. L-carnitine and polyunsaturated fatty acids (PUFAs), exert lipid-lowering effects. Hence, the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested. Subjects and Methods: In a prospective placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs, polyphenols and L-carnitine (PPC) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt. The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells (PBMCs) and HepG2 cells were evaluated. Results: PPC consumption led to significantly reduced plasma free fatty acid (–29%) and triglyceride (–24%) concentrations (each p < 0.05). PPC application increased significantly peroxisome proliferator-activated receptor α (PPARα) mRNA abundances and those of PPARα target genes (carnitine palmitoyltransferases-1, CPT1A and CPT1B, carnitine acetyltransferase and organic cation transporter 2; each p < 0.05) in PBMCs. In controls, plasma lipid levels and PBMC gene expression did not change. These findings were substantiated by the results of cell culture experiments in HepG2 cells. Conclusion: Supplementation of PPC had marked lipid-lowering effects and PBMC gene expression profiles seemed to reflect nutrition-related metabolic changes. |
| language: | eng |
| source: | Alma/SFX Local Collection |
| identifier: | ISSN: 0250-6807 |
| fulltext: | fulltext |
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| url: | Link |
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