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Abstract 102: Role of Renal Tubular NHE3 for Blood Pressure and Salt Homeostasis

The Na + /H + exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney where it facilitates Na + absorption and H + secretion. The importance of NHE3 in the kidney for NaCl homeostasis and blood pressure regulation, relative to the intestine, is not known. To investigate this, we exam... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2016, Vol.68 (suppl_1)
Main Author: Rieg, Timo
Other Authors: Poulsen, Soren B , Dominguez Rieg, Jessica A , Fenton, Robert A
Format: Electronic Article Electronic Article
Language: English
ID: ISSN: 0194-911X
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recordid: cdi_crossref_primary_10_1161_hyp_68_suppl_1_102
title: Abstract 102: Role of Renal Tubular NHE3 for Blood Pressure and Salt Homeostasis
format: Article
creator:
  • Rieg, Timo
  • Poulsen, Soren B
  • Dominguez Rieg, Jessica A
  • Fenton, Robert A
ispartof: Hypertension (Dallas, Tex. 1979), 2016, Vol.68 (suppl_1)
description: The Na + /H + exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney where it facilitates Na + absorption and H + secretion. The importance of NHE3 in the kidney for NaCl homeostasis and blood pressure regulation, relative to the intestine, is not known. To investigate this, we examined kidney-specific NHE3 knockout mice (NHE3 loxloxPax8Cre ) and control mice (Con, NHE3 loxlox ) under normal, low or high dietary NaCl intake. Under normal dietary NaCl intake, no significant differences were detected between genotypes in body weight, fluid or food intake, blood pH and plasma Na + , K + or aldosterone levels. However, urinary pH was significantly elevated in NHE3 loxloxPax8Cre mice and GFR was significantly lower (457±20 vs 358±17 μl/min, P
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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