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Do statins reduce the incidence of stroke in familial hypercholesterolemia?

Familial hypercholesterolemia (FH) causes lifelong elevated serum LDL-cholesterol. In untreated FH, the progression of coronary atherosclerosis and the risk of premature myocardial infarction are substantially increased. In addition, carotid artery atherosclerosis and the risk of ischemic brain infa... Full description

Journal Title: Expert review of cardiovascular therapy 2011-03-01, Vol.9 (3), p.349-353
Main Author: Vuorio, Alpo F
Other Authors: Kovanen, Petri T
Format: Electronic Article Electronic Article
Language: English
Subjects:
MRI
Quelle: Alma/SFX Local Collection
Publisher: London: Informa Healthcare
ID: ISSN: 1477-9072
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recordid: cdi_crossref_primary_10_1586_erc_11_24
title: Do statins reduce the incidence of stroke in familial hypercholesterolemia?
format: Article
creator:
  • Vuorio, Alpo F
  • Kovanen, Petri T
subjects:
  • carotid artery atherosclerosis
  • coronary atherosclerosis
  • Drug therapy
  • familial hypercholesterolemia
  • Health aspects
  • Hypercholesterolemia
  • LDL-cholesterol
  • MRI
  • Risk factors
  • Statins
  • stroke
  • Stroke (Disease)
  • white-matter hyperintensities
ispartof: Expert review of cardiovascular therapy, 2011-03-01, Vol.9 (3), p.349-353
description: Familial hypercholesterolemia (FH) causes lifelong elevated serum LDL-cholesterol. In untreated FH, the progression of coronary atherosclerosis and the risk of premature myocardial infarction are substantially increased. In addition, carotid artery atherosclerosis and the risk of ischemic brain infarction are increased. During the prestatin era, stroke may have been even 20-times more frequent among FH patients than in the general population. In the statin era, both registry studies and MRI studies suggest that the occurrence of ischemic brain damage is not increased among FH patients. It is likely that effective lowering of serum LDL-cholesterol levels made possible by statin treatment has been the key element behind the observed decrease in of the incidence of ischemic stroke. This idea is strongly supported by the results of a recent meta-analysis of controlled statin trials, in which statin treatment was demonstrated to lower the incidence of ischemic stroke among non-FH hypercholesterolemic patients.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1477-9072
fulltext: fulltext
issn:
  • 1477-9072
  • 1744-8344
url: Link


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descriptionFamilial hypercholesterolemia (FH) causes lifelong elevated serum LDL-cholesterol. In untreated FH, the progression of coronary atherosclerosis and the risk of premature myocardial infarction are substantially increased. In addition, carotid artery atherosclerosis and the risk of ischemic brain infarction are increased. During the prestatin era, stroke may have been even 20-times more frequent among FH patients than in the general population. In the statin era, both registry studies and MRI studies suggest that the occurrence of ischemic brain damage is not increased among FH patients. It is likely that effective lowering of serum LDL-cholesterol levels made possible by statin treatment has been the key element behind the observed decrease in of the incidence of ischemic stroke. This idea is strongly supported by the results of a recent meta-analysis of controlled statin trials, in which statin treatment was demonstrated to lower the incidence of ischemic stroke among non-FH hypercholesterolemic patients.
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subjectcarotid artery atherosclerosis ; coronary atherosclerosis ; Drug therapy ; familial hypercholesterolemia ; Health aspects ; Hypercholesterolemia ; LDL-cholesterol ; MRI ; Risk factors ; Statins ; stroke ; Stroke (Disease) ; white-matter hyperintensities
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abstractFamilial hypercholesterolemia (FH) causes lifelong elevated serum LDL-cholesterol. In untreated FH, the progression of coronary atherosclerosis and the risk of premature myocardial infarction are substantially increased. In addition, carotid artery atherosclerosis and the risk of ischemic brain infarction are increased. During the prestatin era, stroke may have been even 20-times more frequent among FH patients than in the general population. In the statin era, both registry studies and MRI studies suggest that the occurrence of ischemic brain damage is not increased among FH patients. It is likely that effective lowering of serum LDL-cholesterol levels made possible by statin treatment has been the key element behind the observed decrease in of the incidence of ischemic stroke. This idea is strongly supported by the results of a recent meta-analysis of controlled statin trials, in which statin treatment was demonstrated to lower the incidence of ischemic stroke among non-FH hypercholesterolemic patients.
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doi10.1586/erc.11.24