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Risks and benefits of dietary isoflavones for cancer

A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than... Full description

Journal Title: Critical reviews in toxicology 2011-07, Vol.41 (6), p.463-506
Main Author: Andres, Susanne
Other Authors: Abraham, Klaus , Appel, Klaus Erich , Lampen, Alfonso
Format: Electronic Article Electronic Article
Language: English
Subjects:
soy
Publisher: London: Informa Healthcare
ID: ISSN: 1040-8444
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recordid: cdi_crossref_primary_10_3109_10408444_2010_541900
title: Risks and benefits of dietary isoflavones for cancer
format: Article
creator:
  • Andres, Susanne
  • Abraham, Klaus
  • Appel, Klaus Erich
  • Lampen, Alfonso
subjects:
  • Animals
  • Anticarcinogenic Agents - administration & dosage
  • Anticarcinogenic Agents - adverse effects
  • Anticarcinogenic Agents - pharmacokinetics
  • Biological and medical sciences
  • Biological Availability
  • Breast cancer
  • carcinogenicity
  • Carcinogenicity Tests
  • Carcinogens - analysis
  • Cardiovascular Diseases - chemically induced
  • Cardiovascular Diseases - prevention & control
  • daidzein
  • Diet
  • Disease Models, Animal
  • Drug Combinations
  • equol
  • estradiol
  • estrogen receptor
  • Female
  • General pharmacology
  • genistein
  • Gynecology. Andrology. Obstetrics
  • Hormone Replacement Therapy
  • Humans
  • Isoflavones - adverse effects
  • Isoflavones - metabolism
  • Isoflavones - pharmacokinetics
  • Male
  • Male genital diseases
  • Mammary gland diseases
  • Medical sciences
  • Neoplasms - chemically induced
  • Neoplasms - prevention & control
  • Nephrology. Urinary tract diseases
  • Osteoporosis, Postmenopausal - chemically induced
  • Osteoporosis, Postmenopausal - prevention & control
  • Pharmacognosy. Homeopathy. Health food
  • Pharmacology. Drug treatments
  • phytoestrogens
  • Phytoestrogens - administration & dosage
  • Phytoestrogens - adverse effects
  • Phytotherapy
  • Plant Extracts - administration & dosage
  • Plant Extracts - adverse effects
  • Plant Extracts - pharmacokinetics
  • prostate cancer
  • red clover
  • Risk Assessment
  • soy
  • Soybeans - chemistry
  • tumor
  • Tumors
  • Tumors of the urinary system
  • Urinary tract. Prostate gland
ispartof: Critical reviews in toxicology, 2011-07, Vol.41 (6), p.463-506
description: A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in Western countries. Hence, interest focuses on soyfoods, soy products, and soy ingredients such as isoflavones with regard to their possible beneficial effects that were observed in numerous experiments and studies. The outcomes of the studies are not always conclusive, are often contradictory depending on the experimental conditions, and are, therefore, difficult to interpret. Isoflavone research revealed not only beneficial but also adverse effects, for instance, on the reproductive system. This is also the case with tumor-promoting effects on, for example, breast tissue. Isoflavone extracts and supplements are often used for the treatment of menopausal symptoms and for the prevention of age-associated conditions such as cardiovascular diseases and osteoporosis in postmenopausal women. In relation to this, questions about the effectiveness and safety of isoflavones have to be clarified. Moreover, there are concerns about the maternal consumption of isoflavones due to the development of leukemia in infants. In contrast, men may benefit from the intake of isoflavones with regard to reducing the risk of prostate cancer. Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments.
language: eng
source:
identifier: ISSN: 1040-8444
fulltext: no_fulltext
issn:
  • 1040-8444
  • 1547-6898
url: Link


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titleRisks and benefits of dietary isoflavones for cancer
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descriptionA high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in Western countries. Hence, interest focuses on soyfoods, soy products, and soy ingredients such as isoflavones with regard to their possible beneficial effects that were observed in numerous experiments and studies. The outcomes of the studies are not always conclusive, are often contradictory depending on the experimental conditions, and are, therefore, difficult to interpret. Isoflavone research revealed not only beneficial but also adverse effects, for instance, on the reproductive system. This is also the case with tumor-promoting effects on, for example, breast tissue. Isoflavone extracts and supplements are often used for the treatment of menopausal symptoms and for the prevention of age-associated conditions such as cardiovascular diseases and osteoporosis in postmenopausal women. In relation to this, questions about the effectiveness and safety of isoflavones have to be clarified. Moreover, there are concerns about the maternal consumption of isoflavones due to the development of leukemia in infants. In contrast, men may benefit from the intake of isoflavones with regard to reducing the risk of prostate cancer. Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments.
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descriptionA high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in Western countries. Hence, interest focuses on soyfoods, soy products, and soy ingredients such as isoflavones with regard to their possible beneficial effects that were observed in numerous experiments and studies. The outcomes of the studies are not always conclusive, are often contradictory depending on the experimental conditions, and are, therefore, difficult to interpret. Isoflavone research revealed not only beneficial but also adverse effects, for instance, on the reproductive system. This is also the case with tumor-promoting effects on, for example, breast tissue. Isoflavone extracts and supplements are often used for the treatment of menopausal symptoms and for the prevention of age-associated conditions such as cardiovascular diseases and osteoporosis in postmenopausal women. In relation to this, questions about the effectiveness and safety of isoflavones have to be clarified. Moreover, there are concerns about the maternal consumption of isoflavones due to the development of leukemia in infants. In contrast, men may benefit from the intake of isoflavones with regard to reducing the risk of prostate cancer. Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments.
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23Hormone Replacement Therapy
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25Isoflavones - adverse effects
26Isoflavones - metabolism
27Isoflavones - pharmacokinetics
28Male
29Male genital diseases
30Mammary gland diseases
31Medical sciences
32Neoplasms - chemically induced
33Neoplasms - prevention & control
34Nephrology. Urinary tract diseases
35Osteoporosis, Postmenopausal - chemically induced
36Osteoporosis, Postmenopausal - prevention & control
37Pharmacognosy. Homeopathy. Health food
38Pharmacology. Drug treatments
39phytoestrogens
40Phytoestrogens - administration & dosage
41Phytoestrogens - adverse effects
42Phytotherapy
43Plant Extracts - administration & dosage
44Plant Extracts - adverse effects
45Plant Extracts - pharmacokinetics
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47red clover
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authorAndres, Susanne ; Abraham, Klaus ; Appel, Klaus Erich ; Lampen, Alfonso
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2Anticarcinogenic Agents - adverse effects
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29Male genital diseases
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34Nephrology. Urinary tract diseases
35Osteoporosis, Postmenopausal - chemically induced
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41Phytoestrogens - adverse effects
42Phytotherapy
43Plant Extracts - administration & dosage
44Plant Extracts - adverse effects
45Plant Extracts - pharmacokinetics
46prostate cancer
47red clover
48Risk Assessment
49soy
50Soybeans - chemistry
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52Tumors
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abstractA high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in Western countries. Hence, interest focuses on soyfoods, soy products, and soy ingredients such as isoflavones with regard to their possible beneficial effects that were observed in numerous experiments and studies. The outcomes of the studies are not always conclusive, are often contradictory depending on the experimental conditions, and are, therefore, difficult to interpret. Isoflavone research revealed not only beneficial but also adverse effects, for instance, on the reproductive system. This is also the case with tumor-promoting effects on, for example, breast tissue. Isoflavone extracts and supplements are often used for the treatment of menopausal symptoms and for the prevention of age-associated conditions such as cardiovascular diseases and osteoporosis in postmenopausal women. In relation to this, questions about the effectiveness and safety of isoflavones have to be clarified. Moreover, there are concerns about the maternal consumption of isoflavones due to the development of leukemia in infants. In contrast, men may benefit from the intake of isoflavones with regard to reducing the risk of prostate cancer. Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments.
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doi10.3109/10408444.2010.541900