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Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population

Background: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX... Full description

Journal Title: Chinese Medical Journal 2016, Vol.129 (7), p.854-859
Main Author: Qin, Fang
Other Authors: Wang, Hu , Song, Lei , Lu, Xi-Li , Yang, Li-Rui , Liang, Er-Peng , Wang, Wei , Zou, Yu-Bao , Bian, Jin , Wu, Hai-Ying , Zhou, Xian-Liang , Hui, Ru-Tai , Zhang, Hui-Min , Jiang, Xiong-Jing
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Publisher: China: Wolters Kluwer - Medknow Publications
ID: ISSN: 0366-6999
Link: https://www.ncbi.nlm.nih.gov/pubmed/26996483
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recordid: cdi_doaj_primary_oai_doaj_org_article_05fca2a6f40b493f9892b2ee213a64cf
title: Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
format: Article
creator:
  • Qin, Fang
  • Wang, Hu
  • Song, Lei
  • Lu, Xi-Li
  • Yang, Li-Rui
  • Liang, Er-Peng
  • Wang, Wei
  • Zou, Yu-Bao
  • Bian, Jin
  • Wu, Hai-Ying
  • Zhou, Xian-Liang
  • Hui, Ru-Tai
  • Zhang, Hui-Min
  • Jiang, Xiong-Jing
subjects:
  • Adolescent
  • Adult
  • Age
  • Aneurysms
  • Arteritis
  • Arthritis
  • Blood pressure
  • Cardiovascular disease
  • Care and treatment
  • Child
  • Classification
  • Coronary vessels
  • Ethnicity
  • Family medical history
  • FCGR2A
  • FCGR2A
  • FCGR3A
  • Single Nucleotide Polymorphisms
  • Takayasu Arteritis
  • FCGR3A
  • Female
  • Genetic Predisposition to Disease
  • Genomes
  • HLA-B
  • Hospitals
  • Humans
  • Hypertension
  • Inflammation
  • Laboratories
  • Male
  • Males
  • Medical imaging
  • Medicine
  • Middle Aged
  • Original
  • Original Article
  • Pathogenesis
  • Polymorphism, Single Nucleotide
  • Population
  • Pulmonary arteries
  • Receptors, IgG - genetics
  • Single Nucleotide Polymorphisms
  • Studies
  • Takayasu Arteritis
  • Takayasu Arteritis - etiology
  • Takayasu Arteritis - genetics
  • Veins & arteries
  • 中国人群
  • 动脉炎
  • 单核苷酸多态性
  • 嗜酸性粒细胞
  • 等位基因频率
  • 遗传易感性
  • 风险因素
ispartof: Chinese Medical Journal, 2016, Vol.129 (7), p.854-859
description: Background: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rsi0919543), and the HLA-B/M1CA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
language: eng
source:
identifier: ISSN: 0366-6999
fulltext: no_fulltext
issn:
  • 0366-6999
  • 2542-5641
url: Link


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titleSingle Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
creatorQin, Fang ; Wang, Hu ; Song, Lei ; Lu, Xi-Li ; Yang, Li-Rui ; Liang, Er-Peng ; Wang, Wei ; Zou, Yu-Bao ; Bian, Jin ; Wu, Hai-Ying ; Zhou, Xian-Liang ; Hui, Ru-Tai ; Zhang, Hui-Min ; Jiang, Xiong-Jing
creatorcontribQin, Fang ; Wang, Hu ; Song, Lei ; Lu, Xi-Li ; Yang, Li-Rui ; Liang, Er-Peng ; Wang, Wei ; Zou, Yu-Bao ; Bian, Jin ; Wu, Hai-Ying ; Zhou, Xian-Liang ; Hui, Ru-Tai ; Zhang, Hui-Min ; Jiang, Xiong-Jing
descriptionBackground: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rsi0919543), and the HLA-B/M1CA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
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languageeng
publisherChina: Wolters Kluwer - Medknow Publications
subjectAdolescent ; Adult ; Age ; Aneurysms ; Arteritis ; Arthritis ; Blood pressure ; Cardiovascular disease ; Care and treatment ; Child ; Classification ; Coronary vessels ; Ethnicity ; Family medical history ; FCGR2A ; FCGR2A; FCGR3A; Single Nucleotide Polymorphisms; Takayasu Arteritis ; FCGR3A ; Female ; Genetic Predisposition to Disease ; Genomes ; HLA-B ; Hospitals ; Humans ; Hypertension ; Inflammation ; Laboratories ; Male ; Males ; Medical imaging ; Medicine ; Middle Aged ; Original ; Original Article ; Pathogenesis ; Polymorphism, Single Nucleotide ; Population ; Pulmonary arteries ; Receptors, IgG - genetics ; Single Nucleotide Polymorphisms ; Studies ; Takayasu Arteritis ; Takayasu Arteritis - etiology ; Takayasu Arteritis - genetics ; Veins & arteries ; 中国人群 ; 动脉炎 ; 单核苷酸多态性 ; 嗜酸性粒细胞 ; 等位基因频率 ; 遗传易感性 ; 风险因素
ispartofChinese Medical Journal, 2016, Vol.129 (7), p.854-859
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2Song, Lei
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4Yang, Li-Rui
5Liang, Er-Peng
6Wang, Wei
7Zou, Yu-Bao
8Bian, Jin
9Wu, Hai-Ying
10Zhou, Xian-Liang
11Hui, Ru-Tai
12Zhang, Hui-Min
13Jiang, Xiong-Jing
title
0Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
1Chinese Medical Journal
addtitleChinese Medical Journal
descriptionBackground: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rsi0919543), and the HLA-B/M1CA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
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5Arthritis
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12Ethnicity
13Family medical history
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15FCGR2A; FCGR3A; Single Nucleotide Polymorphisms; Takayasu Arteritis
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17Female
18Genetic Predisposition to Disease
19Genomes
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24Inflammation
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47嗜酸性粒细胞
48等位基因频率
49遗传易感性
50风险因素
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9Wu, Hai-Ying
10Zhou, Xian-Liang
11Hui, Ru-Tai
12Zhang, Hui-Min
13Jiang, Xiong-Jing
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titleSingle Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
authorQin, Fang ; Wang, Hu ; Song, Lei ; Lu, Xi-Li ; Yang, Li-Rui ; Liang, Er-Peng ; Wang, Wei ; Zou, Yu-Bao ; Bian, Jin ; Wu, Hai-Ying ; Zhou, Xian-Liang ; Hui, Ru-Tai ; Zhang, Hui-Min ; Jiang, Xiong-Jing
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5Arthritis
6Blood pressure
7Cardiovascular disease
8Care and treatment
9Child
10Classification
11Coronary vessels
12Ethnicity
13Family medical history
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15FCGR2A; FCGR3A; Single Nucleotide Polymorphisms; Takayasu Arteritis
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41Takayasu Arteritis - etiology
42Takayasu Arteritis - genetics
43Veins & arteries
44中国人群
45动脉炎
46单核苷酸多态性
47嗜酸性粒细胞
48等位基因频率
49遗传易感性
50风险因素
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8Bian, Jin
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atitleSingle Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
jtitleChinese Medical Journal
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011-2154/R
1FCGR2A, FCGR3A; Single Nucleotide Polymorphisms; Takayasu Arteritis
2Background: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rsi0919543), and the HLA-B/M1CA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
abstractBackground: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rsi0919543), and the HLA-B/M1CA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results: Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
copChina
pubWolters Kluwer - Medknow Publications
pmid26996483
doi10.4103/0366-6999.178965
oafree_for_read