schliessen

Filtern

 

Bibliotheken

Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis

Background:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the perip... Full description

Journal Title: Chinese Medical Journal 2015, Vol.128 (4), p.528-532
Main Author: Shi, Dong
Other Authors: Liu, Yun-Yu , Li, Wei , Zhang, Xin , Sun, Xiao-Jun , Xu, Li , Zhang, Li , Chen, Zhi-Bin , Meng, Huan-Xin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: China: Medknow Publications Pvt Ltd
ID: ISSN: 0366-6999
Link: https://www.ncbi.nlm.nih.gov/pubmed/25673458
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_doaj_primary_oai_doaj_org_article_809c1e28ee6048349cd42ad59aadf3ae
title: Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis
format: Article
creator:
  • Shi, Dong
  • Liu, Yun-Yu
  • Li, Wei
  • Zhang, Xin
  • Sun, Xiao-Jun
  • Xu, Li
  • Zhang, Li
  • Chen, Zhi-Bin
  • Meng, Huan-Xin
subjects:
  • Adolescent
  • Adult
  • Aggressive Periodontitis
  • Aggressive Periodontitis - blood
  • Aggressive Periodontitis - immunology
  • Aggressive Periodontitis
  • Inflammation Mediators
  • Leptin
  • Analysis
  • Biological markers
  • Blood
  • C-Reactive Protein - metabolism
  • Classification
  • Cytokines
  • Diabetes
  • Diagnosis
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gum disease
  • Hospitals
  • Humans
  • Infections
  • Inflammation
  • Inflammation Mediators
  • Interleukin-6 - blood
  • Leptin
  • Leptin - blood
  • Male
  • Medicine
  • Metabolism
  • Middle Aged
  • Original
  • Original Article
  • Periodontitis
  • Physiological aspects
  • Proteins
  • Rodents
  • Systemic diseases
  • Tumor Necrosis Factor-alpha - blood
  • Tumor necrosis factor-TNF
  • Young Adult
  • 侵袭性
  • 多元线性回归分析
  • 标志物
  • 炎症反应
  • 牙周炎
ispartof: Chinese Medical Journal, 2015, Vol.128 (4), p.528-532
description: Background:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.Methods:Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls (staffand student volunteers in the same institute) were recruited.Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β,I L-6,tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay.Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.Results:Plasma leptin level of AgP group was significantly higher than that of the control group (19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P < 0.01).After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β,IL-6,TNF-α and CRP),and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05).Log-transformed IL-1β and I L-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively,P < 0.01).Conclusions:Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.
language: eng
source:
identifier: ISSN: 0366-6999
fulltext: no_fulltext
issn:
  • 0366-6999
  • 2542-5641
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.349238
LOCALfalse
PrimoNMBib
record
control
sourceidgale_doaj_
recordidTN_cdi_doaj_primary_oai_doaj_org_article_809c1e28ee6048349cd42ad59aadf3ae
sourceformatXML
sourcesystemPC
galeidA416964617
cqvip_id664199072
sourcerecordidA416964617
originalsourceidFETCH-LOGICAL-1751t-3b60cbaf286224c963b3be69a0d8535a03f36594f71503009ea4e0019ca40670
addsrcrecordideNp9k81v1DAQxSMEoqVw54QikBCXLbZjO_YFaan4qFSgEr1bjjPJus3aW9vZVf97nG67dCuEcrAUv_fzzPi5KF5jdEwxqj6iivMZl1IeY4YxRk-KQ8IomTFO8dPicLd9ULyI8RIhwljNnxcHhPG6okwcFnEeozdWJ-td2UDaALjyfNBxqcszWCXr8rKGodSuLX_fxARLa8pT1w16udTJh5vyhw5XEGKZpeeZAy7FcmPTopz3fYAY7RrKcwjWt94lm2x8WTzr9BDh1d16VFx8_XJx8n129uvb6cn8bIZrhtOsajgyje6I4IRQI3nVVA1wqVErWMU0qrqKM0m7GjNUISRBU0AIS6Mp4jU6Kk632NbrS7UKdqnDjfLaqtsfPvRKh2TNAEogaTAQAcARFRWVpqVEt0xq3XaVhsz6tGWtxmYJrclNBj3sQfd3nF2o3q9VpnHCZAb83AL8Cpy2AfYLcpBUC-24UptO5R4UqZHIPQMCQRpSd23TmcbUtO46gWrUZuCHu4qCvx4hJrW00cAwaAd-jApzxvI1C0qz9N0j6aUfg8ujV1gSJhCphPir6nWeiHWdz42YCarmFHPJKcfTUI__ocpfOwXDO-hs_r9neP_AsAA9pEX0wzgFLu4L0VZogo8xQLebEEZqSrua4qymOKtt2rPlzcNb2Rnu450F_BHT2HSb9Vy1Hf5H_rw1bvyQcrivhnEDQeVDrpzf7PlmD3yKEaHuX1SGvL07feFdf21dv6uQ5wcqJaoJ-gM9WCog
sourcetypeOpen Website
isCDItrue
recordtypearticle
pqid1925802388
display
typearticle
titleAssociation between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis
creatorShi, Dong ; Liu, Yun-Yu ; Li, Wei ; Zhang, Xin ; Sun, Xiao-Jun ; Xu, Li ; Zhang, Li ; Chen, Zhi-Bin ; Meng, Huan-Xin
creatorcontribShi, Dong ; Liu, Yun-Yu ; Li, Wei ; Zhang, Xin ; Sun, Xiao-Jun ; Xu, Li ; Zhang, Li ; Chen, Zhi-Bin ; Meng, Huan-Xin
descriptionBackground:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.Methods:Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls (staffand student volunteers in the same institute) were recruited.Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β,I L-6,tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay.Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.Results:Plasma leptin level of AgP group was significantly higher than that of the control group (19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P < 0.01).After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β,IL-6,TNF-α and CRP),and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05).Log-transformed IL-1β and I L-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively,P < 0.01).Conclusions:Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.
identifier
0ISSN: 0366-6999
1EISSN: 2542-5641
2DOI: 10.4103/0366-6999.151110
3PMID: 25673458
languageeng
publisherChina: Medknow Publications Pvt Ltd
subjectAdolescent ; Adult ; Aggressive Periodontitis ; Aggressive Periodontitis - blood ; Aggressive Periodontitis - immunology ; Aggressive Periodontitis; Inflammation Mediators; Leptin ; Analysis ; Biological markers ; Blood ; C-Reactive Protein - metabolism ; Classification ; Cytokines ; Diabetes ; Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Female ; Gum disease ; Hospitals ; Humans ; Infections ; Inflammation ; Inflammation Mediators ; Interleukin-6 - blood ; Leptin ; Leptin - blood ; Male ; Medicine ; Metabolism ; Middle Aged ; Original ; Original Article ; Periodontitis ; Physiological aspects ; Proteins ; Rodents ; Systemic diseases ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF ; Young Adult ; 侵袭性 ; 多元线性回归分析 ; 标志物 ; 炎症反应 ; 牙周炎
ispartofChinese Medical Journal, 2015, Vol.128 (4), p.528-532
rights
0COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.
1Copyright Medknow Publications & Media Pvt. Ltd. Feb 20, 2015
2Copyright: © 2015 Chinese Medical Journal 2015
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1751t-3b60cbaf286224c963b3be69a0d8535a03f36594f71503009ea4e0019ca40670
citesFETCH-LOGICAL-1751t-3b60cbaf286224c963b3be69a0d8535a03f36594f71503009ea4e0019ca40670
links
openurl$$Topenurl_article
thumbnail$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25673458$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Shi, Dong
1Liu, Yun-Yu
2Li, Wei
3Zhang, Xin
4Sun, Xiao-Jun
5Xu, Li
6Zhang, Li
7Chen, Zhi-Bin
8Meng, Huan-Xin
title
0Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis
1Chinese Medical Journal
addtitleChinese Medical Journal
descriptionBackground:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.Methods:Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls (staffand student volunteers in the same institute) were recruited.Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β,I L-6,tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay.Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.Results:Plasma leptin level of AgP group was significantly higher than that of the control group (19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P < 0.01).After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β,IL-6,TNF-α and CRP),and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05).Log-transformed IL-1β and I L-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively,P < 0.01).Conclusions:Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.
subject
0Adolescent
1Adult
2Aggressive Periodontitis
3Aggressive Periodontitis - blood
4Aggressive Periodontitis - immunology
5Aggressive Periodontitis; Inflammation Mediators; Leptin
6Analysis
7Biological markers
8Blood
9C-Reactive Protein - metabolism
10Classification
11Cytokines
12Diabetes
13Diagnosis
14Enzyme-Linked Immunosorbent Assay
15Female
16Gum disease
17Hospitals
18Humans
19Infections
20Inflammation
21Inflammation Mediators
22Interleukin-6 - blood
23Leptin
24Leptin - blood
25Male
26Medicine
27Metabolism
28Middle Aged
29Original
30Original Article
31Periodontitis
32Physiological aspects
33Proteins
34Rodents
35Systemic diseases
36Tumor Necrosis Factor-alpha - blood
37Tumor necrosis factor-TNF
38Young Adult
39侵袭性
40多元线性回归分析
41标志物
42炎症反应
43牙周炎
issn
00366-6999
12542-5641
fulltextfalse
rsrctypearticle
creationdate2015
recordtypearticle
recordideNp9k81v1DAQxSMEoqVw54QikBCXLbZjO_YFaan4qFSgEr1bjjPJus3aW9vZVf97nG67dCuEcrAUv_fzzPi5KF5jdEwxqj6iivMZl1IeY4YxRk-KQ8IomTFO8dPicLd9ULyI8RIhwljNnxcHhPG6okwcFnEeozdWJ-td2UDaALjyfNBxqcszWCXr8rKGodSuLX_fxARLa8pT1w16udTJh5vyhw5XEGKZpeeZAy7FcmPTopz3fYAY7RrKcwjWt94lm2x8WTzr9BDh1d16VFx8_XJx8n129uvb6cn8bIZrhtOsajgyje6I4IRQI3nVVA1wqVErWMU0qrqKM0m7GjNUISRBU0AIS6Mp4jU6Kk632NbrS7UKdqnDjfLaqtsfPvRKh2TNAEogaTAQAcARFRWVpqVEt0xq3XaVhsz6tGWtxmYJrclNBj3sQfd3nF2o3q9VpnHCZAb83AL8Cpy2AfYLcpBUC-24UptO5R4UqZHIPQMCQRpSd23TmcbUtO46gWrUZuCHu4qCvx4hJrW00cAwaAd-jApzxvI1C0qz9N0j6aUfg8ujV1gSJhCphPir6nWeiHWdz42YCarmFHPJKcfTUI__ocpfOwXDO-hs_r9neP_AsAA9pEX0wzgFLu4L0VZogo8xQLebEEZqSrua4qymOKtt2rPlzcNb2Rnu450F_BHT2HSb9Vy1Hf5H_rw1bvyQcrivhnEDQeVDrpzf7PlmD3yKEaHuX1SGvL07feFdf21dv6uQ5wcqJaoJ-gM9WCog
startdate2015
enddate2015
creator
0Shi, Dong
1Liu, Yun-Yu
2Li, Wei
3Zhang, Xin
4Sun, Xiao-Jun
5Xu, Li
6Zhang, Li
7Chen, Zhi-Bin
8Meng, Huan-Xin
general
0Medknow Publications Pvt Ltd
1Medknow Publications and Media Pvt. Ltd
2Lippincott Williams & Wilkins Ovid Technologies
3Medknow Publications & Media Pvt Ltd
4Wolters Kluwer
scope
02RA
192L
2CQIGP
3W91
4~WA
5CGR
6CUY
7CVF
8ECM
9EIF
10NPM
11AAYXX
12CITATION
133V.
147X7
157XB
1688E
178FI
188FJ
198FK
20ABUWG
21AZQEC
22BENPR
23DWQXO
24FYUFA
25GHDGH
26K9.
27M0S
28M1P
29PIMPY
30PQEST
31PQQKQ
32PQUKI
33PRINS
347X8
35BOBZL
36CLFQK
375PM
38DOAMJ
sort
creationdate2015
titleAssociation between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis
authorShi, Dong ; Liu, Yun-Yu ; Li, Wei ; Zhang, Xin ; Sun, Xiao-Jun ; Xu, Li ; Zhang, Li ; Chen, Zhi-Bin ; Meng, Huan-Xin
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1751t-3b60cbaf286224c963b3be69a0d8535a03f36594f71503009ea4e0019ca40670
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0Adolescent
1Adult
2Aggressive Periodontitis
3Aggressive Periodontitis - blood
4Aggressive Periodontitis - immunology
5Aggressive Periodontitis; Inflammation Mediators; Leptin
6Analysis
7Biological markers
8Blood
9C-Reactive Protein - metabolism
10Classification
11Cytokines
12Diabetes
13Diagnosis
14Enzyme-Linked Immunosorbent Assay
15Female
16Gum disease
17Hospitals
18Humans
19Infections
20Inflammation
21Inflammation Mediators
22Interleukin-6 - blood
23Leptin
24Leptin - blood
25Male
26Medicine
27Metabolism
28Middle Aged
29Original
30Original Article
31Periodontitis
32Physiological aspects
33Proteins
34Rodents
35Systemic diseases
36Tumor Necrosis Factor-alpha - blood
37Tumor necrosis factor-TNF
38Young Adult
39侵袭性
40多元线性回归分析
41标志物
42炎症反应
43牙周炎
toplevelpeer_reviewed
creatorcontrib
0Shi, Dong
1Liu, Yun-Yu
2Li, Wei
3Zhang, Xin
4Sun, Xiao-Jun
5Xu, Li
6Zhang, Li
7Chen, Zhi-Bin
8Meng, Huan-Xin
collection
0中文科技期刊数据库
1中文科技期刊数据库-CALIS站点
2中文科技期刊数据库-7.0平台
3中文科技期刊数据库-医药卫生
4中文科技期刊数据库- 镜像站点
5Medline
6MEDLINE
7MEDLINE (Ovid)
8MEDLINE
9MEDLINE
10PubMed
11CrossRef
12ProQuest Central (Corporate)
13Health & Medical Collection
14ProQuest Central (purchase pre-March 2016)
15Medical Database (Alumni Edition)
16Hospital Premium Collection
17Hospital Premium Collection (Alumni Edition)
18ProQuest Central (Alumni) (purchase pre-March 2016)
19ProQuest Central (Alumni Edition)
20ProQuest Central Essentials
21ProQuest Central
22ProQuest Central Korea
23Health Research Premium Collection
24Health Research Premium Collection (Alumni)
25ProQuest Health & Medical Complete (Alumni)
26Health & Medical Collection (Alumni Edition)
27Medical Database
28Publicly Available Content Database
29ProQuest One Academic Eastern Edition
30ProQuest One Academic
31ProQuest One Academic UKI Edition
32ProQuest Central China
33MEDLINE - Academic
34OpenAIRE (Open Access)
35OpenAIRE
36PubMed Central (Full Participant titles)
37DOAJ Directory of Open Access Journals
jtitleChinese Medical Journal
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Shi, Dong
1Liu, Yun-Yu
2Li, Wei
3Zhang, Xin
4Sun, Xiao-Jun
5Xu, Li
6Zhang, Li
7Chen, Zhi-Bin
8Meng, Huan-Xin
formatjournal
genrearticle
ristypeJOUR
atitleAssociation between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis
jtitleChinese Medical Journal
addtitleChinese Medical Journal
date2015
risdate2015
volume128
issue4
spage528
epage532
pages528-532
issn0366-6999
eissn2542-5641
notes
0Background:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.Methods:Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls (staffand student volunteers in the same institute) were recruited.Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β,I L-6,tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay.Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.Results:Plasma leptin level of AgP group was significantly higher than that of the control group (19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P < 0.01).After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β,IL-6,TNF-α and CRP),and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05).Log-transformed IL-1β and I L-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively,P < 0.01).Conclusions:Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.
1Aggressive Periodontitis; Inflammation Mediators; Leptin
211-2154/R
abstractBackground:Increasing evidence supports an association between periodontitis and systemic diseases.Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health.The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.Methods:Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls (staffand student volunteers in the same institute) were recruited.Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β,I L-6,tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay.Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.Results:Plasma leptin level of AgP group was significantly higher than that of the control group (19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P < 0.01).After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β,IL-6,TNF-α and CRP),and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05).Log-transformed IL-1β and I L-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively,P < 0.01).Conclusions:Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.
copChina
pubMedknow Publications Pvt Ltd
pmid25673458
doi10.4103/0366-6999.151110
oafree_for_read