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Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention

Background:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculat... Full description

Journal Title: Chinese Medical Journal 2015, Vol.128 (9), p.1147-1150
Main Author: Wei, Li-Ye
Other Authors: Fu, Xiang-Hua , Li, Wei , Bi, Xi-Le , Bai, Shi-Ru , Xing, Kun , Wang, Yan-Bo
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: China: Medknow Publications Pvt Ltd
ID: ISSN: 0366-6999
Link: https://www.ncbi.nlm.nih.gov/pubmed/25947394
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recordid: cdi_doaj_primary_oai_doaj_org_article_c6c8875c092743d7926ae171e6a87cb8
title: Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention
format: Article
creator:
  • Wei, Li-Ye
  • Fu, Xiang-Hua
  • Li, Wei
  • Bi, Xi-Le
  • Bai, Shi-Ru
  • Xing, Kun
  • Wang, Yan-Bo
subjects:
  • Administration, Intravenous
  • Aged
  • Alprostadil - administration & dosage
  • Alprostadil - therapeutic use
  • Angioplasty
  • Cardiac patients
  • Cardiology
  • cardiovascular diseases
  • Care and treatment
  • Coronary vessels
  • Dosage and administration
  • Electrocardiography
  • Female
  • Heart attacks
  • Heart failure
  • Hospitals
  • Humans
  • in E1
  • Intravenous Administration
  • Intravenous Administration
  • Liposomal Prostaglandin E1
  • Primary Percutaneous Coronary Intervention
  • ST Elevation Myocardial Infarction
  • Intubation
  • Laboratories
  • Liposomal Prostagl
  • Liposomal Prostaglandin E1
  • Male
  • Medical imaging
  • Medicine
  • Microcirculation - drug effects
  • Middle Aged
  • Myocardial Infarction - drug therapy
  • Original
  • Original Article
  • Percutaneous Coronary Intervention - methods
  • Performance evaluation
  • Prevention
  • Primary Percutaneous Coronary Intervention
  • Prostaglandins E
  • Reperfusion injury
  • Rodents
  • ST Elevation Myocardial Infarction
  • Studies
  • Veins & arteries
  • 介入治疗
  • 前列腺素E1
  • 微循环
  • 心肌梗死
  • 静脉给药
ispartof: Chinese Medical Journal, 2015, Vol.128 (9), p.1147-1150
description: Background:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculation in reperfusion injury.In addition,this study determined the optimal administration method for acute ST elevation myocardial infarction (STEMI) patients undergoing primary PCI.Methods:Totally,68 patients with STEMI were randomly assigned to two groups:intravenous administration ofLipo-PGE 1 (Group A),and no Lipo-PGE1 administration (Group B).The corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACE) were also measured.Results:There was no significant difference in the baseline characteristics between the two groups.The cTFC parameter in Group A was significantly lower than Group B (18.06 ± 2.06 vs.25.31 ± 2.59,P < 0.01).The ratio of final MBG grade-3 was significantly higher (P < 0.05) in Group A (87.9%) relative to Group B (65.7%).There was no significant difference between the two groups in final TIMI-3 flow and no-reflow.Patients were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B (6.1% vs.25.9% respectively,P < 0.05).Conclusions:Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.
language: eng
source:
identifier: ISSN: 0366-6999
fulltext: no_fulltext
issn:
  • 0366-6999
  • 2542-5641
url: Link


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titleEffect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention
creatorWei, Li-Ye ; Fu, Xiang-Hua ; Li, Wei ; Bi, Xi-Le ; Bai, Shi-Ru ; Xing, Kun ; Wang, Yan-Bo
creatorcontribWei, Li-Ye ; Fu, Xiang-Hua ; Li, Wei ; Bi, Xi-Le ; Bai, Shi-Ru ; Xing, Kun ; Wang, Yan-Bo
descriptionBackground:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculation in reperfusion injury.In addition,this study determined the optimal administration method for acute ST elevation myocardial infarction (STEMI) patients undergoing primary PCI.Methods:Totally,68 patients with STEMI were randomly assigned to two groups:intravenous administration ofLipo-PGE 1 (Group A),and no Lipo-PGE1 administration (Group B).The corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACE) were also measured.Results:There was no significant difference in the baseline characteristics between the two groups.The cTFC parameter in Group A was significantly lower than Group B (18.06 ± 2.06 vs.25.31 ± 2.59,P < 0.01).The ratio of final MBG grade-3 was significantly higher (P < 0.05) in Group A (87.9%) relative to Group B (65.7%).There was no significant difference between the two groups in final TIMI-3 flow and no-reflow.Patients were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B (6.1% vs.25.9% respectively,P < 0.05).Conclusions:Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.
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0ISSN: 0366-6999
1EISSN: 2542-5641
2DOI: 10.4103/0366-6999.156078
3PMID: 25947394
languageeng
publisherChina: Medknow Publications Pvt Ltd
subjectAdministration, Intravenous ; Aged ; Alprostadil - administration & dosage ; Alprostadil - therapeutic use ; Angioplasty ; Cardiac patients ; Cardiology ; cardiovascular diseases ; Care and treatment ; Coronary vessels ; Dosage and administration ; Electrocardiography ; Female ; Heart attacks ; Heart failure ; Hospitals ; Humans ; in E1 ; Intravenous Administration ; Intravenous Administration; Liposomal Prostaglandin E1; Primary Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction ; Intubation ; Laboratories ; Liposomal Prostagl ; Liposomal Prostaglandin E1 ; Male ; Medical imaging ; Medicine ; Microcirculation - drug effects ; Middle Aged ; Myocardial Infarction - drug therapy ; Original ; Original Article ; Percutaneous Coronary Intervention - methods ; Performance evaluation ; Prevention ; Primary Percutaneous Coronary Intervention ; Prostaglandins E ; Reperfusion injury ; Rodents ; ST Elevation Myocardial Infarction ; Studies ; Veins & arteries ; 介入治疗 ; 前列腺素E1 ; 微循环 ; 心肌梗死 ; 静脉给药
ispartofChinese Medical Journal, 2015, Vol.128 (9), p.1147-1150
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2Copyright: © 2015 Chinese Medical Journal 2015
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0Wei, Li-Ye
1Fu, Xiang-Hua
2Li, Wei
3Bi, Xi-Le
4Bai, Shi-Ru
5Xing, Kun
6Wang, Yan-Bo
title
0Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention
1Chinese Medical Journal
addtitleChinese Medical Journal
descriptionBackground:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculation in reperfusion injury.In addition,this study determined the optimal administration method for acute ST elevation myocardial infarction (STEMI) patients undergoing primary PCI.Methods:Totally,68 patients with STEMI were randomly assigned to two groups:intravenous administration ofLipo-PGE 1 (Group A),and no Lipo-PGE1 administration (Group B).The corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACE) were also measured.Results:There was no significant difference in the baseline characteristics between the two groups.The cTFC parameter in Group A was significantly lower than Group B (18.06 ± 2.06 vs.25.31 ± 2.59,P < 0.01).The ratio of final MBG grade-3 was significantly higher (P < 0.05) in Group A (87.9%) relative to Group B (65.7%).There was no significant difference between the two groups in final TIMI-3 flow and no-reflow.Patients were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B (6.1% vs.25.9% respectively,P < 0.05).Conclusions:Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.
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0Administration, Intravenous
1Aged
2Alprostadil - administration & dosage
3Alprostadil - therapeutic use
4Angioplasty
5Cardiac patients
6Cardiology
7cardiovascular diseases
8Care and treatment
9Coronary vessels
10Dosage and administration
11Electrocardiography
12Female
13Heart attacks
14Heart failure
15Hospitals
16Humans
17in E1
18Intravenous Administration
19Intravenous Administration; Liposomal Prostaglandin E1; Primary Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction
20Intubation
21Laboratories
22Liposomal Prostagl
23Liposomal Prostaglandin E1
24Male
25Medical imaging
26Medicine
27Microcirculation - drug effects
28Middle Aged
29Myocardial Infarction - drug therapy
30Original
31Original Article
32Percutaneous Coronary Intervention - methods
33Performance evaluation
34Prevention
35Primary Percutaneous Coronary Intervention
36Prostaglandins E
37Reperfusion injury
38Rodents
39ST Elevation Myocardial Infarction
40Studies
41Veins & arteries
42介入治疗
43前列腺素E1
44微循环
45心肌梗死
46静脉给药
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titleEffect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention
authorWei, Li-Ye ; Fu, Xiang-Hua ; Li, Wei ; Bi, Xi-Le ; Bai, Shi-Ru ; Xing, Kun ; Wang, Yan-Bo
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0Administration, Intravenous
1Aged
2Alprostadil - administration & dosage
3Alprostadil - therapeutic use
4Angioplasty
5Cardiac patients
6Cardiology
7cardiovascular diseases
8Care and treatment
9Coronary vessels
10Dosage and administration
11Electrocardiography
12Female
13Heart attacks
14Heart failure
15Hospitals
16Humans
17in E1
18Intravenous Administration
19Intravenous Administration; Liposomal Prostaglandin E1; Primary Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction
20Intubation
21Laboratories
22Liposomal Prostagl
23Liposomal Prostaglandin E1
24Male
25Medical imaging
26Medicine
27Microcirculation - drug effects
28Middle Aged
29Myocardial Infarction - drug therapy
30Original
31Original Article
32Percutaneous Coronary Intervention - methods
33Performance evaluation
34Prevention
35Primary Percutaneous Coronary Intervention
36Prostaglandins E
37Reperfusion injury
38Rodents
39ST Elevation Myocardial Infarction
40Studies
41Veins & arteries
42介入治疗
43前列腺素E1
44微循环
45心肌梗死
46静脉给药
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1Fu, Xiang-Hua
2Li, Wei
3Bi, Xi-Le
4Bai, Shi-Ru
5Xing, Kun
6Wang, Yan-Bo
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atitleEffect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention
jtitleChinese Medical Journal
addtitleChinese Medical Journal
date2015
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volume128
issue9
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0Intravenous Administration; Liposomal Prostaglandin E l; Primary Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction
111-2154/R
2Background:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculation in reperfusion injury.In addition,this study determined the optimal administration method for acute ST elevation myocardial infarction (STEMI) patients undergoing primary PCI.Methods:Totally,68 patients with STEMI were randomly assigned to two groups:intravenous administration ofLipo-PGE 1 (Group A),and no Lipo-PGE1 administration (Group B).The corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACE) were also measured.Results:There was no significant difference in the baseline characteristics between the two groups.The cTFC parameter in Group A was significantly lower than Group B (18.06 ± 2.06 vs.25.31 ± 2.59,P < 0.01).The ratio of final MBG grade-3 was significantly higher (P < 0.05) in Group A (87.9%) relative to Group B (65.7%).There was no significant difference between the two groups in final TIMI-3 flow and no-reflow.Patients were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B (6.1% vs.25.9% respectively,P < 0.05).Conclusions:Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.
abstractBackground:Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury.This study aims to investigate the effectiveness of liposomal prostaglandin E l (Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.) for enhancing microcirculation in reperfusion injury.In addition,this study determined the optimal administration method for acute ST elevation myocardial infarction (STEMI) patients undergoing primary PCI.Methods:Totally,68 patients with STEMI were randomly assigned to two groups:intravenous administration ofLipo-PGE 1 (Group A),and no Lipo-PGE1 administration (Group B).The corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACE) were also measured.Results:There was no significant difference in the baseline characteristics between the two groups.The cTFC parameter in Group A was significantly lower than Group B (18.06 ± 2.06 vs.25.31 ± 2.59,P < 0.01).The ratio of final MBG grade-3 was significantly higher (P < 0.05) in Group A (87.9%) relative to Group B (65.7%).There was no significant difference between the two groups in final TIMI-3 flow and no-reflow.Patients were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B (6.1% vs.25.9% respectively,P < 0.05).Conclusions:Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.
copChina
pubMedknow Publications Pvt Ltd
pmid25947394
doi10.4103/0366-6999.156078
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