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Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey

Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aim... Full description

Journal Title: Chinese medical journal 2015, Vol.128 (21), p.2843-2850
Main Author: Zhao, De-Wei
Other Authors: Yu, Mang , Hu, Kai , Wang, Wei , Yang, Lei , Wang, Ben-Jie , Gao, Xiao-Hong , Guo, Yong-Ming , Xu, Yong-Qing , Wei, Yu-Shan , Tian, Si-Miao , Yang, Fan , Wang, Nan , Huang, Shi-Bo , Xie, Hui , Wei, Xiao-Wei , Jiang, Hai-Shen , Zang, Yu-Qiang , Ai, Jun , Chen, Yuan-Liang , Lei, Guang-Hua , Li, Yu-Jin , Tian, Geng , Li, Zong-Sheng , Cao, Yong , Ma, Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
NMR
Publisher: China: Medknow Publications Pvt Ltd
ID: ISSN: 0366-6999
Link: https://www.ncbi.nlm.nih.gov/pubmed/26521779
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title: Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey
format: Article
creator:
  • Zhao, De-Wei
  • Yu, Mang
  • Hu, Kai
  • Wang, Wei
  • Yang, Lei
  • Wang, Ben-Jie
  • Gao, Xiao-Hong
  • Guo, Yong-Ming
  • Xu, Yong-Qing
  • Wei, Yu-Shan
  • Tian, Si-Miao
  • Yang, Fan
  • Wang, Nan
  • Huang, Shi-Bo
  • Xie, Hui
  • Wei, Xiao-Wei
  • Jiang, Hai-Shen
  • Zang, Yu-Qiang
  • Ai, Jun
  • Chen, Yuan-Liang
  • Lei, Guang-Hua
  • Li, Yu-Jin
  • Tian, Geng
  • Li, Zong-Sheng
  • Cao, Yong
  • Ma, Li
subjects:
  • Adult
  • Age Distribution
  • Aged
  • Alcohol
  • Asian Continental Ancestry Group
  • Bones
  • Care and treatment
  • China - epidemiology
  • Chinese medicine
  • Data collection
  • Diagnosis
  • Epidemiology
  • Female
  • Femur Head Necrosis - epidemiology
  • Hip joint
  • Hospitals
  • Humans
  • Logistic回归分析
  • Male
  • Medical research
  • Medicine
  • Middle Aged
  • Necrosis
  • NMR
  • Nontraumatic Osteonecrosis of the Femoral Head
  • Nontraumatic Osteonecrosis of the Femoral Head
  • Prevalence
  • Risk Factors
  • Nuclear magnetic resonance
  • Original
  • Original Article
  • Pain
  • Population
  • Prevalence
  • Prevalence studies (Epidemiology)
  • Public health
  • Questionnaires
  • Research centers
  • Risk Factors
  • Studies
  • Usage
  • Young Adult
  • 中国人口
  • 低密度脂蛋白胆固醇
  • 创伤性
  • 危险因素
  • 患病率
  • 股骨头坏死
  • 调查结果
ispartof: Chinese medical journal, 2015, Vol.128 (21), p.2843-2850
description: Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%,x^2= 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions: Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
language: eng
source:
identifier: ISSN: 0366-6999
fulltext: no_fulltext
issn:
  • 0366-6999
  • 2542-5641
url: Link


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titlePrevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey
creatorZhao, De-Wei ; Yu, Mang ; Hu, Kai ; Wang, Wei ; Yang, Lei ; Wang, Ben-Jie ; Gao, Xiao-Hong ; Guo, Yong-Ming ; Xu, Yong-Qing ; Wei, Yu-Shan ; Tian, Si-Miao ; Yang, Fan ; Wang, Nan ; Huang, Shi-Bo ; Xie, Hui ; Wei, Xiao-Wei ; Jiang, Hai-Shen ; Zang, Yu-Qiang ; Ai, Jun ; Chen, Yuan-Liang ; Lei, Guang-Hua ; Li, Yu-Jin ; Tian, Geng ; Li, Zong-Sheng ; Cao, Yong ; Ma, Li
creatorcontribZhao, De-Wei ; Yu, Mang ; Hu, Kai ; Wang, Wei ; Yang, Lei ; Wang, Ben-Jie ; Gao, Xiao-Hong ; Guo, Yong-Ming ; Xu, Yong-Qing ; Wei, Yu-Shan ; Tian, Si-Miao ; Yang, Fan ; Wang, Nan ; Huang, Shi-Bo ; Xie, Hui ; Wei, Xiao-Wei ; Jiang, Hai-Shen ; Zang, Yu-Qiang ; Ai, Jun ; Chen, Yuan-Liang ; Lei, Guang-Hua ; Li, Yu-Jin ; Tian, Geng ; Li, Zong-Sheng ; Cao, Yong ; Ma, Li
descriptionBackground: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%,x^2= 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions: Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
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subjectAdult ; Age Distribution ; Aged ; Alcohol ; Asian Continental Ancestry Group ; Bones ; Care and treatment ; China - epidemiology ; Chinese medicine ; Data collection ; Diagnosis ; Epidemiology ; Female ; Femur Head Necrosis - epidemiology ; Hip joint ; Hospitals ; Humans ; Logistic回归分析 ; Male ; Medical research ; Medicine ; Middle Aged ; Necrosis ; NMR ; Nontraumatic Osteonecrosis of the Femoral Head ; Nontraumatic Osteonecrosis of the Femoral Head; Prevalence; Risk Factors ; Nuclear magnetic resonance ; Original ; Original Article ; Pain ; Population ; Prevalence ; Prevalence studies (Epidemiology) ; Public health ; Questionnaires ; Research centers ; Risk Factors ; Studies ; Usage ; Young Adult ; 中国人口 ; 低密度脂蛋白胆固醇 ; 创伤性 ; 危险因素 ; 患病率 ; 股骨头坏死 ; 调查结果
ispartofChinese medical journal, 2015, Vol.128 (21), p.2843-2850
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descriptionBackground: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%,x^2= 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions: Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
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titlePrevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey
authorZhao, De-Wei ; Yu, Mang ; Hu, Kai ; Wang, Wei ; Yang, Lei ; Wang, Ben-Jie ; Gao, Xiao-Hong ; Guo, Yong-Ming ; Xu, Yong-Qing ; Wei, Yu-Shan ; Tian, Si-Miao ; Yang, Fan ; Wang, Nan ; Huang, Shi-Bo ; Xie, Hui ; Wei, Xiao-Wei ; Jiang, Hai-Shen ; Zang, Yu-Qiang ; Ai, Jun ; Chen, Yuan-Liang ; Lei, Guang-Hua ; Li, Yu-Jin ; Tian, Geng ; Li, Zong-Sheng ; Cao, Yong ; Ma, Li
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notes
011-2154/R
1Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%,x^2= 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions: Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
2Nontraumatic Osteonecrosis of the Femoral Head; Prevalence; Risk Factors
abstractBackground: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%,x^2= 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions: Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
copChina
pubMedknow Publications Pvt Ltd
pmid26521779
doi10.4103/0366-6999.168017
oafree_for_read