schliessen

Filtern

 

Bibliotheken

Quantitative CT measures of emphysema and airway wall thickness are related to DL CO

Summary There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DL CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question What is the relationship between DL CO and the quantitative CT measures... Full description

Journal Title: Respiratory medicine 2010, Vol.105 (3), p.343-351
Main Author: Grydeland, Thomas B
Other Authors: Thorsen, Einar , Dirksen, Asger , Jensen, Robert , Coxson, Harvey O , Pillai, Sreekumar G , Sharma, Sanjay , Eide, Geir Egil , Gulsvik, Amund , Bakke, Per S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
ID: ISSN: 0954-6111
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_elsevier_clinicalkeyesjournals_1_s2_0_S095461111000466X
title: Quantitative CT measures of emphysema and airway wall thickness are related to DL CO
format: Article
creator:
  • Grydeland, Thomas B
  • Thorsen, Einar
  • Dirksen, Asger
  • Jensen, Robert
  • Coxson, Harvey O
  • Pillai, Sreekumar G
  • Sharma, Sanjay
  • Eide, Geir Egil
  • Gulsvik, Amund
  • Bakke, Per S
subjects:
  • Pulmonary/Respiratory
ispartof: Respiratory medicine, 2010, Vol.105 (3), p.343-351
description: Summary There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DL CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question What is the relationship between DL CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0954-6111
fulltext: fulltext
issn:
  • 0954-6111
  • 1532-3064
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK1.8269542
LOCALfalse
PrimoNMBib
record
control
sourceidelsevier
recordidTN_cdi_elsevier_clinicalkeyesjournals_1_s2_0_S095461111000466X
sourceformatXML
sourcesystemPC
sourcerecordid1_s2_0_S095461111000466X
originalsourceidFETCH-elsevier_clinicalkeyesjournals_1_s2_0_S095461111000466X3
addsrcrecordideNqljsFKxDAURYMoWB1_wNX7gdaXNhOcjZuquBBE7GJ24dG-YdJJU0nSGfr3dsQ_cHW5l8PlCHEvsZAo9UNfhIG7osTfoUD5eCEyua7KvEKtLkWGm7XKtZTyWtzE2CPiRinMRPM5kU82UbJHhrqBgSlOgSOMO-Dhez9HHgjId0A2nGiGEzkHaW_bg-cYgQJDYEeJO0gjPL9D_bESVztyke_-8lY8vb409VvOSzlaDqZ11tuW3IFnjv04Bb9wRppYGjRfZ9mzq1w0ldbb6t8HP0dbWUk
sourcetypePublisher
isCDItrue
recordtypearticle
display
typearticle
titleQuantitative CT measures of emphysema and airway wall thickness are related to DL CO
sourceAlma/SFX Local Collection
creatorGrydeland, Thomas B ; Thorsen, Einar ; Dirksen, Asger ; Jensen, Robert ; Coxson, Harvey O ; Pillai, Sreekumar G ; Sharma, Sanjay ; Eide, Geir Egil ; Gulsvik, Amund ; Bakke, Per S
creatorcontribGrydeland, Thomas B ; Thorsen, Einar ; Dirksen, Asger ; Jensen, Robert ; Coxson, Harvey O ; Pillai, Sreekumar G ; Sharma, Sanjay ; Eide, Geir Egil ; Gulsvik, Amund ; Bakke, Per S
descriptionSummary There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DL CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question What is the relationship between DL CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <−950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Results Multiple linear regression analyses showed significant associations between DL CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for DL CO (mmol min−1 kPa−1 ) were −1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models’ adjusted R2 was 0.65 and 0.49, respectively. Conclusions CT measured emphysema explains a large fraction of the variation of DL CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with DL CO, but explains a much smaller fraction of the variation.
identifier
0ISSN: 0954-6111
1EISSN: 1532-3064
2DOI: 10.1016/j.rmed.2010.10.018
languageeng
subjectPulmonary/Respiratory
ispartofRespiratory medicine, 2010, Vol.105 (3), p.343-351
rightsElsevier Ltd
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
search
creatorcontrib
0Grydeland, Thomas B
1Thorsen, Einar
2Dirksen, Asger
3Jensen, Robert
4Coxson, Harvey O
5Pillai, Sreekumar G
6Sharma, Sanjay
7Eide, Geir Egil
8Gulsvik, Amund
9Bakke, Per S
title
0Quantitative CT measures of emphysema and airway wall thickness are related to DL CO
1Respiratory medicine
descriptionSummary There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DL CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question What is the relationship between DL CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <−950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Results Multiple linear regression analyses showed significant associations between DL CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for DL CO (mmol min−1 kPa−1 ) were −1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models’ adjusted R2 was 0.65 and 0.49, respectively. Conclusions CT measured emphysema explains a large fraction of the variation of DL CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with DL CO, but explains a much smaller fraction of the variation.
subjectPulmonary/Respiratory
issn
00954-6111
11532-3064
fulltexttrue
rsrctypearticle
creationdate2010
recordtypearticle
sourceid
recordideNqljsFKxDAURYMoWB1_wNX7gdaXNhOcjZuquBBE7GJ24dG-YdJJU0nSGfr3dsQ_cHW5l8PlCHEvsZAo9UNfhIG7osTfoUD5eCEyua7KvEKtLkWGm7XKtZTyWtzE2CPiRinMRPM5kU82UbJHhrqBgSlOgSOMO-Dhez9HHgjId0A2nGiGEzkHaW_bg-cYgQJDYEeJO0gjPL9D_bESVztyke_-8lY8vb409VvOSzlaDqZ11tuW3IFnjv04Bb9wRppYGjRfZ9mzq1w0ldbb6t8HP0dbWUk
startdate2010
enddate2010
creator
0Grydeland, Thomas B
1Thorsen, Einar
2Dirksen, Asger
3Jensen, Robert
4Coxson, Harvey O
5Pillai, Sreekumar G
6Sharma, Sanjay
7Eide, Geir Egil
8Gulsvik, Amund
9Bakke, Per S
scope
sort
creationdate2010
titleQuantitative CT measures of emphysema and airway wall thickness are related to DL CO
authorGrydeland, Thomas B ; Thorsen, Einar ; Dirksen, Asger ; Jensen, Robert ; Coxson, Harvey O ; Pillai, Sreekumar G ; Sharma, Sanjay ; Eide, Geir Egil ; Gulsvik, Amund ; Bakke, Per S
facets
frbrtype5
frbrgroupidcdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S095461111000466X3
rsrctypearticles
prefilterarticles
languageeng
creationdate2010
topicPulmonary/Respiratory
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Grydeland, Thomas B
1Thorsen, Einar
2Dirksen, Asger
3Jensen, Robert
4Coxson, Harvey O
5Pillai, Sreekumar G
6Sharma, Sanjay
7Eide, Geir Egil
8Gulsvik, Amund
9Bakke, Per S
jtitleRespiratory medicine
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Grydeland, Thomas B
1Thorsen, Einar
2Dirksen, Asger
3Jensen, Robert
4Coxson, Harvey O
5Pillai, Sreekumar G
6Sharma, Sanjay
7Eide, Geir Egil
8Gulsvik, Amund
9Bakke, Per S
formatjournal
genrearticle
ristypeJOUR
atitleQuantitative CT measures of emphysema and airway wall thickness are related to DL CO
jtitleRespiratory medicine
date2010
risdate2010
volume105
issue3
spage343
epage351
pages343-351
issn0954-6111
eissn1532-3064
abstractSummary There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DL CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question What is the relationship between DL CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <−950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Results Multiple linear regression analyses showed significant associations between DL CO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for DL CO (mmol min−1 kPa−1 ) were −1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models’ adjusted R2 was 0.65 and 0.49, respectively. Conclusions CT measured emphysema explains a large fraction of the variation of DL CO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with DL CO, but explains a much smaller fraction of the variation.
doi10.1016/j.rmed.2010.10.018