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Glycaemia but Not the Metabolic Syndrome is Associated with Cognitive Decline: Findings From the European Male Ageing Study

Abstract Objectives Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal... Full description

Journal Title: The American journal of geriatric psychiatry 2017
Main Author: Overman, Margot J, M.Sc
Other Authors: Pendleton, Neil, M.D , O'Neill, Terence W, M.D , Bartfai, Gyorgy, M.D , Casanueva, Felipe F, M.D , Forti, B.Sc Gianni, M.D , Rastrelli, Giulia, M.D , Giwercman, Aleksander, M.D , Han, Thang S, Ph.D , Huhtaniemi, Ilpo T, M.D , Kula, Krzysztof, M.D , Lean, Michael EJ, M.D , Punab, Margus, M.D , Lee, David M, Ph.D , Correa, Elon S, Ph.D , Ahern, Tomas, M.D , Laurent, Michaël R, M.D , Verschueren, Sabine MP, Ph.D , Antonio, Leen, M.D , Gielen, Evelien, M.D , Rutter, Martin K, M.D , Vanderschueren, Dirk, M.D , Wu, Frederick CW, M.D , Tournoy, Jos, M.D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Elsevier
ID: ISSN: 1064-7481
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recordid: cdi_elsevier_clinicalkeyesjournals_1_s2_0_S1064748117301963
title: Glycaemia but Not the Metabolic Syndrome is Associated with Cognitive Decline: Findings From the European Male Ageing Study
format: Article
creator:
  • Overman, Margot J, M.Sc
  • Pendleton, Neil, M.D
  • O'Neill, Terence W, M.D
  • Bartfai, Gyorgy, M.D
  • Casanueva, Felipe F, M.D
  • Forti, B.Sc Gianni, M.D
  • Rastrelli, Giulia, M.D
  • Giwercman, Aleksander, M.D
  • Han, Thang S, Ph.D
  • Huhtaniemi, Ilpo T, M.D
  • Kula, Krzysztof, M.D
  • Lean, Michael EJ, M.D
  • Punab, Margus, M.D
  • Lee, David M, Ph.D
  • Correa, Elon S, Ph.D
  • Ahern, Tomas, M.D
  • Laurent, Michaël R, M.D
  • Verschueren, Sabine MP, Ph.D
  • Antonio, Leen, M.D
  • Gielen, Evelien, M.D
  • Rutter, Martin K, M.D
  • Vanderschueren, Dirk, M.D
  • Wu, Frederick CW, M.D
  • Tournoy, Jos, M.D
subjects:
  • Internal Medicine
ispartof: The American journal of geriatric psychiatry, 2017
description: Abstract Objectives Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed. Design Longitudinal study over a mean of 4.4 (SD ± 0.3) years. Setting Multi-centre European male Ageing Study (EMAS). Participants Men aged 40-79 years. Measurements Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time ( p >0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy ( β =-0.42, p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
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titleGlycaemia but Not the Metabolic Syndrome is Associated with Cognitive Decline: Findings From the European Male Ageing Study
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creatorOverman, Margot J, M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W, M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F, M.D ; Forti, B.Sc Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S, Ph.D ; Huhtaniemi, Ilpo T, M.D ; Kula, Krzysztof, M.D ; Lean, Michael EJ, M.D ; Punab, Margus, M.D ; Lee, David M, Ph.D ; Correa, Elon S, Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R, M.D ; Verschueren, Sabine MP, Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K, M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick CW, M.D ; Tournoy, Jos, M.D
creatorcontribOverman, Margot J, M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W, M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F, M.D ; Forti, B.Sc Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S, Ph.D ; Huhtaniemi, Ilpo T, M.D ; Kula, Krzysztof, M.D ; Lean, Michael EJ, M.D ; Punab, Margus, M.D ; Lee, David M, Ph.D ; Correa, Elon S, Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R, M.D ; Verschueren, Sabine MP, Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K, M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick CW, M.D ; Tournoy, Jos, M.D
descriptionAbstract Objectives Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed. Design Longitudinal study over a mean of 4.4 (SD ± 0.3) years. Setting Multi-centre European male Ageing Study (EMAS). Participants Men aged 40-79 years. Measurements Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time ( p >0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy ( β =-0.42, p <0.05) and the DSST ( β =-0.39, p <0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusions We found no evidence for a relationship between MetS or inflammation and cognitive decline in this sample of ageing men. However, glycaemia was negatively associated with visuo-constructional abilities and processing speed.
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0Glycaemia but Not the Metabolic Syndrome is Associated with Cognitive Decline: Findings From the European Male Ageing Study
1The American journal of geriatric psychiatry
descriptionAbstract Objectives Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed. Design Longitudinal study over a mean of 4.4 (SD ± 0.3) years. Setting Multi-centre European male Ageing Study (EMAS). Participants Men aged 40-79 years. Measurements Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time ( p >0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy ( β =-0.42, p <0.05) and the DSST ( β =-0.39, p <0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusions We found no evidence for a relationship between MetS or inflammation and cognitive decline in this sample of ageing men. However, glycaemia was negatively associated with visuo-constructional abilities and processing speed.
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titleGlycaemia but Not the Metabolic Syndrome is Associated with Cognitive Decline: Findings From the European Male Ageing Study
authorOverman, Margot J, M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W, M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F, M.D ; Forti, B.Sc Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S, Ph.D ; Huhtaniemi, Ilpo T, M.D ; Kula, Krzysztof, M.D ; Lean, Michael EJ, M.D ; Punab, Margus, M.D ; Lee, David M, Ph.D ; Correa, Elon S, Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R, M.D ; Verschueren, Sabine MP, Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K, M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick CW, M.D ; Tournoy, Jos, M.D
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abstractAbstract Objectives Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed. Design Longitudinal study over a mean of 4.4 (SD ± 0.3) years. Setting Multi-centre European male Ageing Study (EMAS). Participants Men aged 40-79 years. Measurements Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time ( p >0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy ( β =-0.42, p <0.05) and the DSST ( β =-0.39, p <0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusions We found no evidence for a relationship between MetS or inflammation and cognitive decline in this sample of ageing men. However, glycaemia was negatively associated with visuo-constructional abilities and processing speed.
pubElsevier
doi10.1016/j.jagp.2017.02.004
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