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Quantitative CT measures of emphysema and airway wall thickness are related to D LCO

There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D LCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D LCO and the quantitative CT measures of emphysema and airway... Full description

Journal Title: Respiratory medicine 2011, Vol.105 (3), p.343-351
Main Author: Grydeland, Thomas B
Other Authors: Thorsen, Einar , Dirksen, Asger , Jensen, Robert , Coxson, Harvey O , Pillai, Sreekumar G , Sharma, Sanjay , Eide, Geir Egil , Gulsvik, Amund , Bakke, Per S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Elsevier Ltd
ID: ISSN: 0954-6111
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recordid: cdi_elsevier_sciencedirect_doi_10_1016_j_rmed_2010_10_018
title: Quantitative CT measures of emphysema and airway wall thickness are related to D LCO
format: Article
creator:
  • Grydeland, Thomas B
  • Thorsen, Einar
  • Dirksen, Asger
  • Jensen, Robert
  • Coxson, Harvey O
  • Pillai, Sreekumar G
  • Sharma, Sanjay
  • Eide, Geir Egil
  • Gulsvik, Amund
  • Bakke, Per S
subjects:
  • Airways disease
  • Chronic obstructive pulmonary disease
  • Computed tomography
  • Diffusing capacity
  • Emphysema
ispartof: Respiratory medicine, 2011, Vol.105 (3), p.343-351
description: There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D LCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D LCO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0954-6111
fulltext: fulltext
issn:
  • 0954-6111
  • 1532-3064
url: Link


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titleQuantitative CT measures of emphysema and airway wall thickness are related to D LCO
sourceAlma/SFX Local Collection
creatorGrydeland, Thomas B ; Thorsen, Einar ; Dirksen, Asger ; Jensen, Robert ; Coxson, Harvey O ; Pillai, Sreekumar G ; Sharma, Sanjay ; Eide, Geir Egil ; Gulsvik, Amund ; Bakke, Per S
creatorcontribGrydeland, Thomas B ; Thorsen, Einar ; Dirksen, Asger ; Jensen, Robert ; Coxson, Harvey O ; Pillai, Sreekumar G ; Sharma, Sanjay ; Eide, Geir Egil ; Gulsvik, Amund ; Bakke, Per S
descriptionThere is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D LCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D LCO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <−950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D LCO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D LCO (mmol min −1 kPa −1) were −1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models’ adjusted R 2 was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D LCO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D LCO, but explains a much smaller fraction of the variation.
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abstractThere is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D LCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. What is the relationship between D LCO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <−950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Multiple linear regression analyses showed significant associations between D LCO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for D LCO (mmol min −1 kPa −1) were −1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models’ adjusted R 2 was 0.65 and 0.49, respectively. CT measured emphysema explains a large fraction of the variation of D LCO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with D LCO, but explains a much smaller fraction of the variation.
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doi10.1016/j.rmed.2010.10.018
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