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Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole

In an attempt to develop stable and safe antifungal agents from natural products (daily foodstuffs in particular), the activities of essential oils from Allium sativum for. pekinense, A. cepa, and A. fistulosum against three Trichophyton species responsible for severe mycoses in humans were investig... Full description

Journal Title: Phytomedicine (Stuttgart) 2006, Vol.13 (6), p.394-400
Main Author: Pyun, M.-S
Other Authors: Shin, S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/16716908
Zum Text:
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title: Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole
format: Article
creator:
  • Pyun, M.-S
  • Shin, S
subjects:
  • Allicin
  • Allium
  • Allium spp
  • Antifungal activity
  • Antifungal agents
  • Antifungal Agents - administration & dosage
  • Antifungal Agents - pharmacology
  • Antifungal Agents - therapeutic use
  • Drug Synergism
  • Humans
  • Ketoconazole
  • Ketoconazole - administration & dosage
  • Ketoconazole - pharmacology
  • Ketoconazole - therapeutic use
  • Microbial Sensitivity Tests
  • Phytotherapy
  • Plant Oils - administration & dosage
  • Plant Oils - chemistry
  • Plant Oils - pharmacology
  • Plant Oils - therapeutic use
  • Synergism
  • Tinea - drug therapy
  • Trichophyton
  • Trichophyton - drug effects
  • Usage
  • Volatile oils
ispartof: Phytomedicine (Stuttgart), 2006, Vol.13 (6), p.394-400
description: In an attempt to develop stable and safe antifungal agents from natural products (daily foodstuffs in particular), the activities of essential oils from Allium sativum for. pekinense, A. cepa, and A. fistulosum against three Trichophyton species responsible for severe mycoses in humans were investigated and compared with activity of allicin in this study. The fungistatic activities of Allium oils were evaluated by the broth dilution method and disk diffusion assay. The combined effects of Allium oils with ketoconazole were tested by the checkerboard titer test. Among the tested oils, A. sativum for. pekinense oil exhibited the strongest inhibition of growth of T. rubrum, T. erinacei, and T. soudanense with MICs (minimum inhibiting concentrations) of 64 μg/ml, while the activities of A. cepa and A. fistulosum were relatively mild. The inhibiting activities of the oils on Sabouraud agar plates were dose dependent against Trichophyton species. Additionally, these oils showed significant synergistic antifungal activity when combined with ketoconazole in the checkerboard titer test and disk diffusion test.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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descriptionIn an attempt to develop stable and safe antifungal agents from natural products (daily foodstuffs in particular), the activities of essential oils from Allium sativum for. pekinense, A. cepa, and A. fistulosum against three Trichophyton species responsible for severe mycoses in humans were investigated and compared with activity of allicin in this study. The fungistatic activities of Allium oils were evaluated by the broth dilution method and disk diffusion assay. The combined effects of Allium oils with ketoconazole were tested by the checkerboard titer test. Among the tested oils, A. sativum for. pekinense oil exhibited the strongest inhibition of growth of T. rubrum, T. erinacei, and T. soudanense with MICs (minimum inhibiting concentrations) of 64 μg/ml, while the activities of A. cepa and A. fistulosum were relatively mild. The inhibiting activities of the oils on Sabouraud agar plates were dose dependent against Trichophyton species. Additionally, these oils showed significant synergistic antifungal activity when combined with ketoconazole in the checkerboard titer test and disk diffusion test.
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languageeng
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subjectAllicin ; Allium ; Allium spp ; Antifungal activity ; Antifungal agents ; Antifungal Agents - administration & dosage ; Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Drug Synergism ; Humans ; Ketoconazole ; Ketoconazole - administration & dosage ; Ketoconazole - pharmacology ; Ketoconazole - therapeutic use ; Microbial Sensitivity Tests ; Phytotherapy ; Plant Oils - administration & dosage ; Plant Oils - chemistry ; Plant Oils - pharmacology ; Plant Oils - therapeutic use ; Synergism ; Tinea - drug therapy ; Trichophyton ; Trichophyton - drug effects ; Usage ; Volatile oils
ispartofPhytomedicine (Stuttgart), 2006, Vol.13 (6), p.394-400
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abstractIn an attempt to develop stable and safe antifungal agents from natural products (daily foodstuffs in particular), the activities of essential oils from Allium sativum for. pekinense, A. cepa, and A. fistulosum against three Trichophyton species responsible for severe mycoses in humans were investigated and compared with activity of allicin in this study. The fungistatic activities of Allium oils were evaluated by the broth dilution method and disk diffusion assay. The combined effects of Allium oils with ketoconazole were tested by the checkerboard titer test. Among the tested oils, A. sativum for. pekinense oil exhibited the strongest inhibition of growth of T. rubrum, T. erinacei, and T. soudanense with MICs (minimum inhibiting concentrations) of 64 μg/ml, while the activities of A. cepa and A. fistulosum were relatively mild. The inhibiting activities of the oils on Sabouraud agar plates were dose dependent against Trichophyton species. Additionally, these oils showed significant synergistic antifungal activity when combined with ketoconazole in the checkerboard titer test and disk diffusion test.
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