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Two vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control

Abstract Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microar... Full description

Journal Title: Vaccine 2007, Vol.25 (17), p.3355-3364
Main Author: Hamaguchi, Isao
Other Authors: Imai, Jun-ichi , Momose, Haruka , Kawamura, Mika , Mizukami, Takuo , Kato, Hiroshi , Naito, Seishiro , Maeyama, Jun-ichi , Masumi, Atsuko , Kuramitsu, Madoka , Takizawa, Kazuya , Mochizuki, Masayo , Ochiai, Masaki , Yamamoto, Akihiko , Horiuchi, Yoshinobu , Nomura, Nobuo , Watanabe, Shinya , Yamaguchi, Kazunari
Format: Electronic Article Electronic Article
Language: English
Subjects:
Agp
Hpx
Quelle: Alma/SFX Local Collection
Publisher: Oxford: Elsevier Ltd
ID: ISSN: 0264-410X
Zum Text:
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recordid: cdi_gale_infotracacademiconefile_A161762420
title: Two vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control
format: Article
creator:
  • Hamaguchi, Isao
  • Imai, Jun-ichi
  • Momose, Haruka
  • Kawamura, Mika
  • Mizukami, Takuo
  • Kato, Hiroshi
  • Naito, Seishiro
  • Maeyama, Jun-ichi
  • Masumi, Atsuko
  • Kuramitsu, Madoka
  • Takizawa, Kazuya
  • Mochizuki, Masayo
  • Ochiai, Masaki
  • Yamamoto, Akihiko
  • Horiuchi, Yoshinobu
  • Nomura, Nobuo
  • Watanabe, Shinya
  • Yamaguchi, Kazunari
subjects:
  • Agp
  • Allergy and Immunology
  • Analysis
  • Animals
  • Applied microbiology
  • Bacterial diseases
  • Biological and medical sciences
  • DNA microarrays
  • Ent and stomatologic bacterial diseases
  • Fundamental and applied biological sciences. Psychology
  • Gene expression
  • Genetic research
  • Hemopexin - genetics
  • Hpx
  • Human bacterial diseases
  • Infectious diseases
  • Leukocytosis - etiology
  • Liver - metabolism
  • Male
  • Medical sciences
  • Microarray
  • Microbiology
  • Oligonucleotide Array Sequence Analysis
  • Orosomucoid - genetics
  • Pertussis toxin
  • Pertussis Toxin - analysis
  • Pertussis vaccine
  • Pertussis Vaccine - toxicity
  • Polymerase Chain Reaction
  • Quantitative RT-PCR
  • Rats
  • Rats, Wistar
  • RNA, Messenger - analysis
  • Rodents
  • Safety
  • Safety and security measures
  • Safety test
  • Toxicity
  • Vaccines
  • Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
  • Whooping cough
ispartof: Vaccine, 2007, Vol.25 (17), p.3355-3364
description: Abstract Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microarray-based gene expression data revealed a gene expression pattern highly correlated with leukocytosis in animals. Of 10,490 rat genes analyzed, two genes, α1-acid-glycoprotein (Agp) and hemopexin (Hpx), were found up-regulated by the toxin administration in a dose-dependent manner (assayed by a quantitative PCR based on the microarray). Variation of the gene expression was very small amongst the test animals, and the results were highly reproducible. These findings suggest that gene expression analysis of vaccine-treated animals can be used as an accurate and simple method of pertussis vaccine safety assessment.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titleTwo vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control
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descriptionAbstract Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microarray-based gene expression data revealed a gene expression pattern highly correlated with leukocytosis in animals. Of 10,490 rat genes analyzed, two genes, α1-acid-glycoprotein (Agp) and hemopexin (Hpx), were found up-regulated by the toxin administration in a dose-dependent manner (assayed by a quantitative PCR based on the microarray). Variation of the gene expression was very small amongst the test animals, and the results were highly reproducible. These findings suggest that gene expression analysis of vaccine-treated animals can be used as an accurate and simple method of pertussis vaccine safety assessment.
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languageeng
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subjectAgp ; Allergy and Immunology ; Analysis ; Animals ; Applied microbiology ; Bacterial diseases ; Biological and medical sciences ; DNA microarrays ; Ent and stomatologic bacterial diseases ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genetic research ; Hemopexin - genetics ; Hpx ; Human bacterial diseases ; Infectious diseases ; Leukocytosis - etiology ; Liver - metabolism ; Male ; Medical sciences ; Microarray ; Microbiology ; Oligonucleotide Array Sequence Analysis ; Orosomucoid - genetics ; Pertussis toxin ; Pertussis Toxin - analysis ; Pertussis vaccine ; Pertussis Vaccine - toxicity ; Polymerase Chain Reaction ; Quantitative RT-PCR ; Rats ; Rats, Wistar ; RNA, Messenger - analysis ; Rodents ; Safety ; Safety and security measures ; Safety test ; Toxicity ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Whooping cough
ispartofVaccine, 2007, Vol.25 (17), p.3355-3364
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1Imai, Jun-ichi
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13Yamamoto, Akihiko
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17Yamaguchi, Kazunari
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descriptionAbstract Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microarray-based gene expression data revealed a gene expression pattern highly correlated with leukocytosis in animals. Of 10,490 rat genes analyzed, two genes, α1-acid-glycoprotein (Agp) and hemopexin (Hpx), were found up-regulated by the toxin administration in a dose-dependent manner (assayed by a quantitative PCR based on the microarray). Variation of the gene expression was very small amongst the test animals, and the results were highly reproducible. These findings suggest that gene expression analysis of vaccine-treated animals can be used as an accurate and simple method of pertussis vaccine safety assessment.
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titleTwo vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control
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abstractAbstract Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microarray-based gene expression data revealed a gene expression pattern highly correlated with leukocytosis in animals. Of 10,490 rat genes analyzed, two genes, α1-acid-glycoprotein (Agp) and hemopexin (Hpx), were found up-regulated by the toxin administration in a dose-dependent manner (assayed by a quantitative PCR based on the microarray). Variation of the gene expression was very small amongst the test animals, and the results were highly reproducible. These findings suggest that gene expression analysis of vaccine-treated animals can be used as an accurate and simple method of pertussis vaccine safety assessment.
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pubElsevier Ltd
pmid17280746
doi10.1016/j.vaccine.2006.12.059