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Mechanisms of combined action of different chemopreventive dietary compounds: a review

Consumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific c... Full description

Journal Title: European journal of nutrition 2008-01-01, Vol.47 (Suppl 2), p.51-59
Main Author: de Kok, T.M
Other Authors: van Breda, S.G , Manson, M.M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Dordrecht: D. Steinkopff-Verlag
ID: ISSN: 1436-6207
Link: https://www.ncbi.nlm.nih.gov/pubmed/18458834
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title: Mechanisms of combined action of different chemopreventive dietary compounds: a review
format: Article
creator:
  • de Kok, T.M
  • van Breda, S.G
  • Manson, M.M
subjects:
  • Anticarcinogenic Agents - administration & dosage
  • Anticarcinogenic Agents - therapeutic use
  • Article
  • Chemistry
  • Chemistry and Materials Science
  • Chemoprevention
  • Drug Synergism
  • Flavonoids - administration & dosage
  • Flavonoids - therapeutic use
  • Fruit - chemistry
  • Humans
  • Neoplasms - prevention & control
  • Nutrition
  • Phenols - administration & dosage
  • Phenols - therapeutic use
  • phytochemicals
  • Plant Extracts - administration & dosage
  • Plant Extracts - therapeutic use
  • Polyphenols
  • synergistic effects
  • vegetables
  • Vegetables - chemistry
ispartof: European journal of nutrition, 2008-01-01, Vol.47 (Suppl 2), p.51-59
description: Consumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug–phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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descriptionConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug–phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
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subjectAnticarcinogenic Agents - administration & dosage ; Anticarcinogenic Agents - therapeutic use ; Article ; Chemistry ; Chemistry and Materials Science ; Chemoprevention ; Drug Synergism ; Flavonoids - administration & dosage ; Flavonoids - therapeutic use ; Fruit - chemistry ; Humans ; Neoplasms - prevention & control ; Nutrition ; Phenols - administration & dosage ; Phenols - therapeutic use ; phytochemicals ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; Polyphenols ; synergistic effects ; vegetables ; Vegetables - chemistry
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descriptionConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug–phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
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abstractConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug–phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
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