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Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk

Byline: Rod Jackson (a), Carlene MM Lawes (b), Derrick A Bennett (b), Richard J Milne (a), Anthony Rodgers (b) In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their... Full description

Journal Title: The Lancet (British edition) 2005-01-29, Vol.365 (9457), p.434-441
Main Author: Jackson, Rod
Other Authors: Lawes, Carlene MM , Bennett, Derrick A , Milne, Richard J , Rodgers, Anthony
Format: Electronic Article Electronic Article
Language: English
Quelle: Alma/SFX Local Collection
Publisher: Elsevier B.V
ID: ISSN: 0140-6736
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title: Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
format: Article
creator:
  • Jackson, Rod
  • Lawes, Carlene MM
  • Bennett, Derrick A
  • Milne, Richard J
  • Rodgers, Anthony
ispartof: The Lancet (British edition), 2005-01-29, Vol.365 (9457), p.434-441
description: Byline: Rod Jackson (a), Carlene MM Lawes (b), Derrick A Bennett (b), Richard J Milne (a), Anthony Rodgers (b) In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors. Author Affiliation: (a) Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (b) Clinical Trials Research Unit, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionByline: Rod Jackson (a), Carlene MM Lawes (b), Derrick A Bennett (b), Richard J Milne (a), Anthony Rodgers (b) In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors. Author Affiliation: (a) Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (b) Clinical Trials Research Unit, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
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abstractByline: Rod Jackson (a), Carlene MM Lawes (b), Derrick A Bennett (b), Richard J Milne (a), Anthony Rodgers (b) In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors. Author Affiliation: (a) Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (b) Clinical Trials Research Unit, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
pubElsevier B.V
doi10.1016/S0140-6736(05)70240-3