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Comparative study of the plasma globulin level, CD21.sup.- B-cell counts and FOXP3 mRNA expression level in CD4.sup.+ T-cells for different clinical stages of feline immunodeficiency virus infected cats

Byline: Tomomi Takano, Shinobu Hosoya, Akari Shibao, Bunpei Nagasaki, Hisao Yoshioka, Ryoichi Satoh, Tsutomu Hohdatsu Keywords: FIV; Hypergammaglobulinemia; CD21.sup.- B-cell; Regulatory T-cell Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that rema... Full description

Journal Title: Research in veterinary science 2012, Vol.92 (1), p.157
Main Author: Takano, Tomomi
Other Authors: Hosoya, Shinobu , Shibao, Akari , Nagasaki, Bunpei , Yoshioka, Hisao , Satoh, Ryoichi , Hohdatsu, Tsutomu
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Elsevier B.V
ID: ISSN: 0034-5288
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recordid: cdi_gale_infotracacademiconefile_A275645300
title: Comparative study of the plasma globulin level, CD21.sup.- B-cell counts and FOXP3 mRNA expression level in CD4.sup.+ T-cells for different clinical stages of feline immunodeficiency virus infected cats
format: Article
creator:
  • Takano, Tomomi
  • Hosoya, Shinobu
  • Shibao, Akari
  • Nagasaki, Bunpei
  • Yoshioka, Hisao
  • Satoh, Ryoichi
  • Hohdatsu, Tsutomu
subjects:
  • Cats
  • Comparative analysis
  • Immunoglobulins
  • Messenger RNA
  • T cells
  • Virus diseases
ispartof: Research in veterinary science, 2012, Vol.92 (1), p.157
description: Byline: Tomomi Takano, Shinobu Hosoya, Akari Shibao, Bunpei Nagasaki, Hisao Yoshioka, Ryoichi Satoh, Tsutomu Hohdatsu Keywords: FIV; Hypergammaglobulinemia; CD21.sup.- B-cell; Regulatory T-cell Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4.sup.+ T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg).sup.+ CD21.sup.- B-cell counts were increased, whereas the CD4.sup.+ T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4.sup.+ T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia. Author Affiliation: Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan Article History: Received 16 August 2010; Accepted 20 October 2010
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0034-5288
fulltext: fulltext
issn:
  • 0034-5288
  • 1532-2661
url: Link


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titleComparative study of the plasma globulin level, CD21.sup.- B-cell counts and FOXP3 mRNA expression level in CD4.sup.+ T-cells for different clinical stages of feline immunodeficiency virus infected cats
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titleComparative study of the plasma globulin level, CD21.sup.- B-cell counts and FOXP3 mRNA expression level in CD4.sup.+ T-cells for different clinical stages of feline immunodeficiency virus infected cats
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abstractByline: Tomomi Takano, Shinobu Hosoya, Akari Shibao, Bunpei Nagasaki, Hisao Yoshioka, Ryoichi Satoh, Tsutomu Hohdatsu Keywords: FIV; Hypergammaglobulinemia; CD21.sup.- B-cell; Regulatory T-cell Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia through mechanisms that remain poorly understood. We investigated changes in plasma globulin level, B cells, and T cells with progression of the clinical stage of FIV-infected cats. We classified FIV-infected cats into the stage of Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical symptoms, and measured the plasma globulin level, the CD4.sup.+ T-cell counts, and analyzed surface markers of B cells. We investigated the relationship between the plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level and the surface immunoglobulin (sIg).sup.+ CD21.sup.- B-cell counts were increased, whereas the CD4.sup.+ T-cell counts were decreased compared with specific-pathogen free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was increased in peripheral blood, and the FOXP3 mRNA expression level was decreased in CD4.sup.+ T-cells. These immunological changes were marked in the ARC stage. These data indicate that the decrease of Tregs and the increase of plasma cells lead to hypergammaglobulinemia. Author Affiliation: Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan Article History: Received 16 August 2010; Accepted 20 October 2010
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