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Applied Pharmacogenomics in Cardiovascular Medicine

Interindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substan... Full description

Journal Title: Annual review of medicine 2014-01-14, Vol.65 (1), p.81-94
Main Author: Weeke, Peter
Other Authors: Roden, Dan M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews
ID: ISSN: 0066-4219
Link: https://www.ncbi.nlm.nih.gov/pubmed/24111889
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recordid: cdi_gale_infotracacademiconefile_A355560818
title: Applied Pharmacogenomics in Cardiovascular Medicine
format: Article
creator:
  • Weeke, Peter
  • Roden, Dan M
subjects:
  • Adrenergic beta-Antagonists - therapeutic use
  • Anticoagulants
  • Antihypertensive Agents
  • Antithrombins - metabolism
  • Antithrombins - therapeutic use
  • Article
  • Aryl Hydrocarbon Hydroxylases - genetics
  • Cardiovascular diseases
  • Cardiovascular Diseases - chemically induced
  • Cardiovascular Diseases - drug therapy
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - metabolism
  • Cardiovascular system
  • clopidogrel
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2C9
  • Drug therapy
  • Genes
  • Genetic aspects
  • genetics
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
  • Organic Anion Transporters - genetics
  • personalized medicine
  • Pharmacogenetics
  • Pharmacogenetics - trends
  • Polymorphism, Single Nucleotide
  • polymorphisms
  • Precision Medicine
  • Risk assessment
  • Solute Carrier Organic Anion Transporter Family Member 1b1
  • statin
  • Stents
  • Thrombosis
  • Ticlopidine - analogs & derivatives
  • Ticlopidine - metabolism
  • Ticlopidine - therapeutic use
  • Vitamin K Epoxide Reductases - genetics
  • warfarin
  • Warfarin - metabolism
  • Warfarin - therapeutic use
ispartof: Annual review of medicine, 2014-01-14, Vol.65 (1), p.81-94
description: Interindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substantially to variable efficacy and toxicity. Important associations of pharmacogenomics in cardiovascular medicine include clopidogrel and risk for in-stent thrombosis, steady-state warfarin dose, myotoxicity with simvastatin, and certain drug-induced arrhythmias. This review describes methods used to accumulate and validate these findings and points to approaches-now being put in place at some centers-to implementing them in clinical care.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4219
fulltext: fulltext
issn:
  • 0066-4219
  • 1545-326X
url: Link


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descriptionInterindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substantially to variable efficacy and toxicity. Important associations of pharmacogenomics in cardiovascular medicine include clopidogrel and risk for in-stent thrombosis, steady-state warfarin dose, myotoxicity with simvastatin, and certain drug-induced arrhythmias. This review describes methods used to accumulate and validate these findings and points to approaches-now being put in place at some centers-to implementing them in clinical care.
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subjectAdrenergic beta-Antagonists - therapeutic use ; Anticoagulants ; Antihypertensive Agents ; Antithrombins - metabolism ; Antithrombins - therapeutic use ; Article ; Aryl Hydrocarbon Hydroxylases - genetics ; Cardiovascular diseases ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cardiovascular system ; clopidogrel ; Cytochrome P-450 CYP2C19 ; Cytochrome P-450 CYP2C9 ; Drug therapy ; Genes ; Genetic aspects ; genetics ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Organic Anion Transporters - genetics ; personalized medicine ; Pharmacogenetics ; Pharmacogenetics - trends ; Polymorphism, Single Nucleotide ; polymorphisms ; Precision Medicine ; Risk assessment ; Solute Carrier Organic Anion Transporter Family Member 1b1 ; statin ; Stents ; Thrombosis ; Ticlopidine - analogs & derivatives ; Ticlopidine - metabolism ; Ticlopidine - therapeutic use ; Vitamin K Epoxide Reductases - genetics ; warfarin ; Warfarin - metabolism ; Warfarin - therapeutic use
ispartofAnnual review of medicine, 2014-01-14, Vol.65 (1), p.81-94
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descriptionInterindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substantially to variable efficacy and toxicity. Important associations of pharmacogenomics in cardiovascular medicine include clopidogrel and risk for in-stent thrombosis, steady-state warfarin dose, myotoxicity with simvastatin, and certain drug-induced arrhythmias. This review describes methods used to accumulate and validate these findings and points to approaches-now being put in place at some centers-to implementing them in clinical care.
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28Precision Medicine
29Risk assessment
30Solute Carrier Organic Anion Transporter Family Member 1b1
31statin
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33Thrombosis
34Ticlopidine - analogs & derivatives
35Ticlopidine - metabolism
36Ticlopidine - therapeutic use
37Vitamin K Epoxide Reductases - genetics
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abstractInterindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substantially to variable efficacy and toxicity. Important associations of pharmacogenomics in cardiovascular medicine include clopidogrel and risk for in-stent thrombosis, steady-state warfarin dose, myotoxicity with simvastatin, and certain drug-induced arrhythmias. This review describes methods used to accumulate and validate these findings and points to approaches-now being put in place at some centers-to implementing them in clinical care.
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doi10.1146/annurev-med-101712-122545
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