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Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats

Diabetes-induced damages in brain are known as diabetic encephalopathy, which is well characterized by cellular, molecular and functional changes in the brain of diabetic subjects and rodents. However, little is known about the mechanism of damages and the therapeutic strategies in ameliorating thos... Full description

Journal Title: Neurological sciences 2014-01-11, Vol.35 (7), p.1003-1008
Main Author: Ola, Mohammad S
Other Authors: Aleisa, Abdulaziz M , Al-Rejaie, Salim S , Abuohashish, Hatem M , Parmar, Mihir Y , Alhomida, Abdullah S , Ahmed, Mohammed M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Milan: Springer Milan
ID: ISSN: 1590-1874
Link: https://www.ncbi.nlm.nih.gov/pubmed/24413816
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title: Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats
format: Article
creator:
  • Ola, Mohammad S
  • Aleisa, Abdulaziz M
  • Al-Rejaie, Salim S
  • Abuohashish, Hatem M
  • Parmar, Mihir Y
  • Alhomida, Abdullah S
  • Ahmed, Mohammed M
subjects:
  • Animals
  • Antioxidants - pharmacology
  • Antioxidants - therapeutic use
  • Bioflavonoids
  • Blood Glucose - drug effects
  • Body Weight - drug effects
  • Brain - drug effects
  • Brain - physiopathology
  • Brain damage
  • Catalase - metabolism
  • Cytokines - metabolism
  • Dextrose
  • Diabetes Mellitus, Experimental - complications
  • Diabetes Mellitus, Experimental - drug therapy
  • Diabetes Mellitus, Experimental - pathology
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Flavones
  • Flavonoids
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • Glucose
  • Glucose metabolism
  • Glutathione - metabolism
  • Inflammation
  • Inflammation - drug therapy
  • Inflammation - etiology
  • Inflammation - metabolism
  • Male
  • Medicine
  • Medicine & Public Health
  • Nerve growth factor
  • Nerve Growth Factors - metabolism
  • Nervous system diseases
  • Neurology
  • Neuroradiology
  • Neurosurgery
  • Original Article
  • Oxidative stress
  • Oxidative Stress - drug effects
  • Psychiatry
  • Rats
  • Rats, Wistar
  • Streptozocin
  • Superoxide
  • Superoxide Dismutase - metabolism
  • Thiobarbituric Acid Reactive Substances - metabolism
ispartof: Neurological sciences, 2014-01-11, Vol.35 (7), p.1003-1008
description: Diabetes-induced damages in brain are known as diabetic encephalopathy, which is well characterized by cellular, molecular and functional changes in the brain of diabetic subjects and rodents. However, little is known about the mechanism of damages and the therapeutic strategies in ameliorating those damages in the diabetic brain. In this study, we utilized a flavonoid, morin which is emerging as a potent drug against a wide range of free radical-mediated as well as neurodegenerative diseases. Morin (15 and 30 mg/kg body weight/day) was orally administered to two different groups of rats after 1 week of diabetes induction, and continued for five consecutive weeks. Two other untreated groups of diabetic and non-diabetic rats were used to compare with drug-treated groups. After drug treatments, cerebral cortex of the brain harvested and analyzed for different factors. Morin supplementation especially at high dose increased the levels of insulin, reduced glutathione, superoxide dismutase and catalase activities, and decreased fasting glucose and thiobarbituric acid reactive substances in the diabetic brain compared to untreated diabetic rats ( P  
language: eng
source:
identifier: ISSN: 1590-1874
fulltext: no_fulltext
issn:
  • 1590-1874
  • 1590-3478
url: Link


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titleFlavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats
creatorOla, Mohammad S ; Aleisa, Abdulaziz M ; Al-Rejaie, Salim S ; Abuohashish, Hatem M ; Parmar, Mihir Y ; Alhomida, Abdullah S ; Ahmed, Mohammed M
creatorcontribOla, Mohammad S ; Aleisa, Abdulaziz M ; Al-Rejaie, Salim S ; Abuohashish, Hatem M ; Parmar, Mihir Y ; Alhomida, Abdullah S ; Ahmed, Mohammed M
descriptionDiabetes-induced damages in brain are known as diabetic encephalopathy, which is well characterized by cellular, molecular and functional changes in the brain of diabetic subjects and rodents. However, little is known about the mechanism of damages and the therapeutic strategies in ameliorating those damages in the diabetic brain. In this study, we utilized a flavonoid, morin which is emerging as a potent drug against a wide range of free radical-mediated as well as neurodegenerative diseases. Morin (15 and 30 mg/kg body weight/day) was orally administered to two different groups of rats after 1 week of diabetes induction, and continued for five consecutive weeks. Two other untreated groups of diabetic and non-diabetic rats were used to compare with drug-treated groups. After drug treatments, cerebral cortex of the brain harvested and analyzed for different factors. Morin supplementation especially at high dose increased the levels of insulin, reduced glutathione, superoxide dismutase and catalase activities, and decreased fasting glucose and thiobarbituric acid reactive substances in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Morin also significantly decreased the level of inflammatory markers (TNFα, IL1β, IL-6) in the diabetic brain compared to untreated diabetic rats. Furthermore, the drug influenced an increase in the level of neurotrophic factors (BDNF, NGF and IGF-1) in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Thus, our results indicate a beneficial effect of morin by decreasing oxidative stress, inflammation and increasing the neurotrophic support in the diabetic brain, which may ameliorate diabetic encephalopathy.
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languageeng
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subjectAnimals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Bioflavonoids ; Blood Glucose - drug effects ; Body Weight - drug effects ; Brain - drug effects ; Brain - physiopathology ; Brain damage ; Catalase - metabolism ; Cytokines - metabolism ; Dextrose ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Flavones ; Flavonoids ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Glucose ; Glucose metabolism ; Glutathione - metabolism ; Inflammation ; Inflammation - drug therapy ; Inflammation - etiology ; Inflammation - metabolism ; Male ; Medicine ; Medicine & Public Health ; Nerve growth factor ; Nerve Growth Factors - metabolism ; Nervous system diseases ; Neurology ; Neuroradiology ; Neurosurgery ; Original Article ; Oxidative stress ; Oxidative Stress - drug effects ; Psychiatry ; Rats ; Rats, Wistar ; Streptozocin ; Superoxide ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism
ispartofNeurological sciences, 2014-01-11, Vol.35 (7), p.1003-1008
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3Abuohashish, Hatem M
4Parmar, Mihir Y
5Alhomida, Abdullah S
6Ahmed, Mohammed M
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descriptionDiabetes-induced damages in brain are known as diabetic encephalopathy, which is well characterized by cellular, molecular and functional changes in the brain of diabetic subjects and rodents. However, little is known about the mechanism of damages and the therapeutic strategies in ameliorating those damages in the diabetic brain. In this study, we utilized a flavonoid, morin which is emerging as a potent drug against a wide range of free radical-mediated as well as neurodegenerative diseases. Morin (15 and 30 mg/kg body weight/day) was orally administered to two different groups of rats after 1 week of diabetes induction, and continued for five consecutive weeks. Two other untreated groups of diabetic and non-diabetic rats were used to compare with drug-treated groups. After drug treatments, cerebral cortex of the brain harvested and analyzed for different factors. Morin supplementation especially at high dose increased the levels of insulin, reduced glutathione, superoxide dismutase and catalase activities, and decreased fasting glucose and thiobarbituric acid reactive substances in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Morin also significantly decreased the level of inflammatory markers (TNFα, IL1β, IL-6) in the diabetic brain compared to untreated diabetic rats. Furthermore, the drug influenced an increase in the level of neurotrophic factors (BDNF, NGF and IGF-1) in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Thus, our results indicate a beneficial effect of morin by decreasing oxidative stress, inflammation and increasing the neurotrophic support in the diabetic brain, which may ameliorate diabetic encephalopathy.
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2Antioxidants - therapeutic use
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6Brain - drug effects
7Brain - physiopathology
8Brain damage
9Catalase - metabolism
10Cytokines - metabolism
11Dextrose
12Diabetes Mellitus, Experimental - complications
13Diabetes Mellitus, Experimental - drug therapy
14Diabetes Mellitus, Experimental - pathology
15Disease Models, Animal
16Dose-Response Relationship, Drug
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21Glucose
22Glucose metabolism
23Glutathione - metabolism
24Inflammation
25Inflammation - drug therapy
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titleFlavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats
authorOla, Mohammad S ; Aleisa, Abdulaziz M ; Al-Rejaie, Salim S ; Abuohashish, Hatem M ; Parmar, Mihir Y ; Alhomida, Abdullah S ; Ahmed, Mohammed M
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atitleFlavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats
jtitleNeurological sciences
stitleNeurol Sci
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date2014-01-11
risdate2014
volume35
issue7
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pages1003-1008
issn1590-1874
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abstractDiabetes-induced damages in brain are known as diabetic encephalopathy, which is well characterized by cellular, molecular and functional changes in the brain of diabetic subjects and rodents. However, little is known about the mechanism of damages and the therapeutic strategies in ameliorating those damages in the diabetic brain. In this study, we utilized a flavonoid, morin which is emerging as a potent drug against a wide range of free radical-mediated as well as neurodegenerative diseases. Morin (15 and 30 mg/kg body weight/day) was orally administered to two different groups of rats after 1 week of diabetes induction, and continued for five consecutive weeks. Two other untreated groups of diabetic and non-diabetic rats were used to compare with drug-treated groups. After drug treatments, cerebral cortex of the brain harvested and analyzed for different factors. Morin supplementation especially at high dose increased the levels of insulin, reduced glutathione, superoxide dismutase and catalase activities, and decreased fasting glucose and thiobarbituric acid reactive substances in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Morin also significantly decreased the level of inflammatory markers (TNFα, IL1β, IL-6) in the diabetic brain compared to untreated diabetic rats. Furthermore, the drug influenced an increase in the level of neurotrophic factors (BDNF, NGF and IGF-1) in the diabetic brain compared to untreated diabetic rats ( P  < 0.05). Thus, our results indicate a beneficial effect of morin by decreasing oxidative stress, inflammation and increasing the neurotrophic support in the diabetic brain, which may ameliorate diabetic encephalopathy.
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pubSpringer Milan
pmid24413816
doi10.1007/s10072-014-1628-5