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Antileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice

Chenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases. To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide). Anti-leishmanial effect was... Full description

Journal Title: Phytomedicine (Stuttgart) 2014-07, Vol.21 (8-9), p.1048-1052
Main Author: Monzote, L
Other Authors: Pastor, J , Scull, R , Gille, L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/24768411
Zum Text:
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title: Antileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice
format: Article
creator:
  • Monzote, L
  • Pastor, J
  • Scull, R
  • Gille, L
subjects:
  • Amaranthaceae
  • Animals
  • Antiprotozoal Agents - chemistry
  • Antiprotozoal Agents - isolation & purification
  • Antiprotozoal Agents - pharmacology
  • Ascaridole
  • Care and treatment
  • Carvacrol
  • Caryophyllene oxide
  • Chenopodium ambrosioides
  • Chenopodium ambrosioides - chemistry
  • Cutaneous leishmanasis
  • Cyclohexane Monoterpenes
  • Cymenes
  • Essences and essential oils
  • Female
  • Health aspects
  • Injections, Intralesional
  • Leishmania - drug effects
  • Leishmaniasis, Cutaneous
  • Leishmaniasis, Cutaneous - drug therapy
  • Meglumine - pharmacology
  • Meglumine Antimoniate
  • Mice
  • Mice, Inbred BALB C
  • Monoterpenes - chemistry
  • Monoterpenes - isolation & purification
  • Monoterpenes - pharmacology
  • Oils, Volatile - chemistry
  • Oils, Volatile - isolation & purification
  • Oils, Volatile - pharmacology
  • Organometallic Compounds - pharmacology
  • Peroxides - chemistry
  • Peroxides - isolation & purification
  • Peroxides - pharmacology
  • Plant Oils - chemistry
  • Plant Oils - isolation & purification
  • Plant Oils - pharmacology
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes - chemistry
  • Sesquiterpenes - isolation & purification
  • Sesquiterpenes - pharmacology
  • Usage
ispartof: Phytomedicine (Stuttgart), 2014-07, Vol.21 (8-9), p.1048-1052
description: Chenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases. To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide). Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined. EO prevented lesion development compared (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleAntileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice
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creatorMonzote, L ; Pastor, J ; Scull, R ; Gille, L
creatorcontribMonzote, L ; Pastor, J ; Scull, R ; Gille, L
descriptionChenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases. To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide). Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined. EO prevented lesion development compared (p<0.05) with untreated animals and treated with vehicle. In addition, the efficacy of EO was also statistically superior (p<0.05) compared with the glucantime-treated animals. No potential effects were observed with pure components treatment. Mix of pure compounds cause death of animals after 3 days of treatment. Our results demonstrate the superiority of EO against experimental cutaneous leishmaniasis caused by L. amazonensis.
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2DOI: 10.1016/j.phymed.2014.03.002
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languageeng
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descriptionChenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases. To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide). Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined. EO prevented lesion development compared (p<0.05) with untreated animals and treated with vehicle. In addition, the efficacy of EO was also statistically superior (p<0.05) compared with the glucantime-treated animals. No potential effects were observed with pure components treatment. Mix of pure compounds cause death of animals after 3 days of treatment. Our results demonstrate the superiority of EO against experimental cutaneous leishmaniasis caused by L. amazonensis.
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1Animals
2Antiprotozoal Agents - chemistry
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5Ascaridole
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12Cyclohexane Monoterpenes
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14Essences and essential oils
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17Injections, Intralesional
18Leishmania - drug effects
19Leishmaniasis, Cutaneous
20Leishmaniasis, Cutaneous - drug therapy
21Meglumine - pharmacology
22Meglumine Antimoniate
23Mice
24Mice, Inbred BALB C
25Monoterpenes - chemistry
26Monoterpenes - isolation & purification
27Monoterpenes - pharmacology
28Oils, Volatile - chemistry
29Oils, Volatile - isolation & purification
30Oils, Volatile - pharmacology
31Organometallic Compounds - pharmacology
32Peroxides - chemistry
33Peroxides - isolation & purification
34Peroxides - pharmacology
35Plant Oils - chemistry
36Plant Oils - isolation & purification
37Plant Oils - pharmacology
38Polycyclic Sesquiterpenes
39Sesquiterpenes - chemistry
40Sesquiterpenes - isolation & purification
41Sesquiterpenes - pharmacology
42Usage
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authorMonzote, L ; Pastor, J ; Scull, R ; Gille, L
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atitleAntileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice
jtitlePhytomedicine (Stuttgart)
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date2014-07
risdate2014
volume21
issue8-9
spage1048
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pages1048-1052
issn0944-7113
eissn1618-095X
abstractChenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases. To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide). Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined. EO prevented lesion development compared (p<0.05) with untreated animals and treated with vehicle. In addition, the efficacy of EO was also statistically superior (p<0.05) compared with the glucantime-treated animals. No potential effects were observed with pure components treatment. Mix of pure compounds cause death of animals after 3 days of treatment. Our results demonstrate the superiority of EO against experimental cutaneous leishmaniasis caused by L. amazonensis.
copGermany
pubElsevier GmbH
pmid24768411
doi10.1016/j.phymed.2014.03.002
tpages5