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Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)

Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major in... Full description

Journal Title: Parasitology research (1987) 2015-02-12, Vol.114 (4), p.1551-1562
Main Author: Suresh, Udaiyan
Other Authors: Murugan, Kadarkarai , Benelli, Giovanni , Nicoletti, Marcello , Barnard, Donald R , Panneerselvam, Chellasamy , Kumar, Palanisamy Mahesh , Subramaniam, Jayapal , Dinesh, Devakumar , Chandramohan, Balamurugan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0932-0113
Link: https://www.ncbi.nlm.nih.gov/pubmed/25669140
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recordid: cdi_gale_infotracacademiconefile_A424632731
title: Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)
format: Article
creator:
  • Suresh, Udaiyan
  • Murugan, Kadarkarai
  • Benelli, Giovanni
  • Nicoletti, Marcello
  • Barnard, Donald R
  • Panneerselvam, Chellasamy
  • Kumar, Palanisamy Mahesh
  • Subramaniam, Jayapal
  • Dinesh, Devakumar
  • Chandramohan, Balamurugan
subjects:
  • Aedes - drug effects
  • Aedes - growth & development
  • Animals
  • Biomedical and Life Sciences
  • Biomedicine
  • Control
  • Dengue
  • Dengue - transmission
  • Dicotyledons
  • Health aspects
  • Humans
  • Immunology
  • Insect Vectors - drug effects
  • Insecticides - chemical synthesis
  • Insecticides - toxicity
  • Larva - drug effects
  • Larva - growth & development
  • Medical Microbiology
  • Metal Nanoparticles - chemistry
  • Metal Nanoparticles - toxicity
  • Methods
  • Microbiology
  • Mosquito Control
  • Nanoparticles
  • Original Paper
  • Phyllanthus - chemistry
  • Plant Extracts - chemistry
  • Plant Extracts - toxicity
  • Plant Leaves - chemistry
  • Production processes
  • Silver
  • Silver - chemistry
  • Silver - toxicity
  • Surface Plasmon Resonance
  • Vector control
ispartof: Parasitology research (1987), 2015-02-12, Vol.114 (4), p.1551-1562
description: Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. Aedes aegypti (Diptera: Culicidae) is the primary vector of dengue. The use of synthetic insecticides to control Aedes mosquitoes lead to high operational costs and adverse nontarget effects. In this scenario, eco-friendly control tools are a priority. We proposed a novel method to synthesize silver nanoparticles using the aqueous leaf extract of Phyllanthus niruri , a cheap and nontoxic material. The UV–vis spectrum of the aqueous medium containing silver nanostructures showed a peak at 420 nm corresponding to the surface plasmon resonance band of nanoparticles. SEM analyses of the synthesized nanoparticles showed a mean size of 30–60 nm. EDX spectrum showed the chemical composition of the synthesized nanoparticles. XRD highlighted that the nanoparticles are crystalline in nature with face-centered cubic geometry. Fourier transform infrared spectroscopy (FTIR) of nanoparticles exhibited prominent peaks 3,327.63, 2,125.87, 1,637.89, 644.35, 597.41, and 554.63 cm −1 . In laboratory assays, the aqueous extract of P. niruri was toxic against larval instars (I–IV) and pupae of A. aegypti . LC 50 was 158.24 ppm (I), 183.20 ppm (II), 210.53 ppm (III), 210.53 ppm (IV), and 358.08 ppm (pupae). P. niruri -synthesized nanoparticles were highly effective against A. aegypti , with LC 50 of 3.90 ppm (I), 5.01 ppm (II), 6.2 ppm (III), 8.9 ppm (IV), and 13.04 ppm (pupae). In the field, the application of silver nanoparticles (10 × LC 50 ) lead to A. aegypti larval reduction of 47.6 %, 76.7 % and 100 %, after 24, 48, and 72 h, while the P. niruri extract lead to 39.9 %, 69.2 % and 100 % of reduction, respectively. In adulticidal experiments, P. niruri extract and nanoparticles showed LC 50 and LC 90 of 174.14 and 6.68 ppm and 422.29 and 23.58 ppm, respectively. Overall, this study highlights that the possibility to employ P. niruri leaf extract and green-synthesized silver nanoparticles in mosquito control programs is concrete, since both are effective at lower doses if compared to synthetic products currently marketed, thus they could be an advantageous alternative to build newer and safer tools against dengue vectors.
language: eng
source:
identifier: ISSN: 0932-0113
fulltext: no_fulltext
issn:
  • 0932-0113
  • 1432-1955
url: Link


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titleTackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)
creatorSuresh, Udaiyan ; Murugan, Kadarkarai ; Benelli, Giovanni ; Nicoletti, Marcello ; Barnard, Donald R ; Panneerselvam, Chellasamy ; Kumar, Palanisamy Mahesh ; Subramaniam, Jayapal ; Dinesh, Devakumar ; Chandramohan, Balamurugan
creatorcontribSuresh, Udaiyan ; Murugan, Kadarkarai ; Benelli, Giovanni ; Nicoletti, Marcello ; Barnard, Donald R ; Panneerselvam, Chellasamy ; Kumar, Palanisamy Mahesh ; Subramaniam, Jayapal ; Dinesh, Devakumar ; Chandramohan, Balamurugan
descriptionMosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. Aedes aegypti (Diptera: Culicidae) is the primary vector of dengue. The use of synthetic insecticides to control Aedes mosquitoes lead to high operational costs and adverse nontarget effects. In this scenario, eco-friendly control tools are a priority. We proposed a novel method to synthesize silver nanoparticles using the aqueous leaf extract of Phyllanthus niruri , a cheap and nontoxic material. The UV–vis spectrum of the aqueous medium containing silver nanostructures showed a peak at 420 nm corresponding to the surface plasmon resonance band of nanoparticles. SEM analyses of the synthesized nanoparticles showed a mean size of 30–60 nm. EDX spectrum showed the chemical composition of the synthesized nanoparticles. XRD highlighted that the nanoparticles are crystalline in nature with face-centered cubic geometry. Fourier transform infrared spectroscopy (FTIR) of nanoparticles exhibited prominent peaks 3,327.63, 2,125.87, 1,637.89, 644.35, 597.41, and 554.63 cm −1 . In laboratory assays, the aqueous extract of P. niruri was toxic against larval instars (I–IV) and pupae of A. aegypti . LC 50 was 158.24 ppm (I), 183.20 ppm (II), 210.53 ppm (III), 210.53 ppm (IV), and 358.08 ppm (pupae). P. niruri -synthesized nanoparticles were highly effective against A. aegypti , with LC 50 of 3.90 ppm (I), 5.01 ppm (II), 6.2 ppm (III), 8.9 ppm (IV), and 13.04 ppm (pupae). In the field, the application of silver nanoparticles (10 × LC 50 ) lead to A. aegypti larval reduction of 47.6 %, 76.7 % and 100 %, after 24, 48, and 72 h, while the P. niruri extract lead to 39.9 %, 69.2 % and 100 % of reduction, respectively. In adulticidal experiments, P. niruri extract and nanoparticles showed LC 50 and LC 90 of 174.14 and 6.68 ppm and 422.29 and 23.58 ppm, respectively. Overall, this study highlights that the possibility to employ P. niruri leaf extract and green-synthesized silver nanoparticles in mosquito control programs is concrete, since both are effective at lower doses if compared to synthetic products currently marketed, thus they could be an advantageous alternative to build newer and safer tools against dengue vectors.
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0ISSN: 0932-0113
1EISSN: 1432-1955
2DOI: 10.1007/s00436-015-4339-9
3PMID: 25669140
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAedes - drug effects ; Aedes - growth & development ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Control ; Dengue ; Dengue - transmission ; Dicotyledons ; Health aspects ; Humans ; Immunology ; Insect Vectors - drug effects ; Insecticides - chemical synthesis ; Insecticides - toxicity ; Larva - drug effects ; Larva - growth & development ; Medical Microbiology ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - toxicity ; Methods ; Microbiology ; Mosquito Control ; Nanoparticles ; Original Paper ; Phyllanthus - chemistry ; Plant Extracts - chemistry ; Plant Extracts - toxicity ; Plant Leaves - chemistry ; Production processes ; Silver ; Silver - chemistry ; Silver - toxicity ; Surface Plasmon Resonance ; Vector control
ispartofParasitology research (1987), 2015-02-12, Vol.114 (4), p.1551-1562
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citedbyFETCH-LOGICAL-c407t-e51441ec79ab10167b3f73302f2646c04e3378d98291465cf3f5533c233367a40
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0Suresh, Udaiyan
1Murugan, Kadarkarai
2Benelli, Giovanni
3Nicoletti, Marcello
4Barnard, Donald R
5Panneerselvam, Chellasamy
6Kumar, Palanisamy Mahesh
7Subramaniam, Jayapal
8Dinesh, Devakumar
9Chandramohan, Balamurugan
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0Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)
1Parasitology research (1987)
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descriptionMosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. Aedes aegypti (Diptera: Culicidae) is the primary vector of dengue. The use of synthetic insecticides to control Aedes mosquitoes lead to high operational costs and adverse nontarget effects. In this scenario, eco-friendly control tools are a priority. We proposed a novel method to synthesize silver nanoparticles using the aqueous leaf extract of Phyllanthus niruri , a cheap and nontoxic material. The UV–vis spectrum of the aqueous medium containing silver nanostructures showed a peak at 420 nm corresponding to the surface plasmon resonance band of nanoparticles. SEM analyses of the synthesized nanoparticles showed a mean size of 30–60 nm. EDX spectrum showed the chemical composition of the synthesized nanoparticles. XRD highlighted that the nanoparticles are crystalline in nature with face-centered cubic geometry. Fourier transform infrared spectroscopy (FTIR) of nanoparticles exhibited prominent peaks 3,327.63, 2,125.87, 1,637.89, 644.35, 597.41, and 554.63 cm −1 . In laboratory assays, the aqueous extract of P. niruri was toxic against larval instars (I–IV) and pupae of A. aegypti . LC 50 was 158.24 ppm (I), 183.20 ppm (II), 210.53 ppm (III), 210.53 ppm (IV), and 358.08 ppm (pupae). P. niruri -synthesized nanoparticles were highly effective against A. aegypti , with LC 50 of 3.90 ppm (I), 5.01 ppm (II), 6.2 ppm (III), 8.9 ppm (IV), and 13.04 ppm (pupae). In the field, the application of silver nanoparticles (10 × LC 50 ) lead to A. aegypti larval reduction of 47.6 %, 76.7 % and 100 %, after 24, 48, and 72 h, while the P. niruri extract lead to 39.9 %, 69.2 % and 100 % of reduction, respectively. In adulticidal experiments, P. niruri extract and nanoparticles showed LC 50 and LC 90 of 174.14 and 6.68 ppm and 422.29 and 23.58 ppm, respectively. Overall, this study highlights that the possibility to employ P. niruri leaf extract and green-synthesized silver nanoparticles in mosquito control programs is concrete, since both are effective at lower doses if compared to synthetic products currently marketed, thus they could be an advantageous alternative to build newer and safer tools against dengue vectors.
subject
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1Aedes - growth & development
2Animals
3Biomedical and Life Sciences
4Biomedicine
5Control
6Dengue
7Dengue - transmission
8Dicotyledons
9Health aspects
10Humans
11Immunology
12Insect Vectors - drug effects
13Insecticides - chemical synthesis
14Insecticides - toxicity
15Larva - drug effects
16Larva - growth & development
17Medical Microbiology
18Metal Nanoparticles - chemistry
19Metal Nanoparticles - toxicity
20Methods
21Microbiology
22Mosquito Control
23Nanoparticles
24Original Paper
25Phyllanthus - chemistry
26Plant Extracts - chemistry
27Plant Extracts - toxicity
28Plant Leaves - chemistry
29Production processes
30Silver
31Silver - chemistry
32Silver - toxicity
33Surface Plasmon Resonance
34Vector control
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titleTackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)
authorSuresh, Udaiyan ; Murugan, Kadarkarai ; Benelli, Giovanni ; Nicoletti, Marcello ; Barnard, Donald R ; Panneerselvam, Chellasamy ; Kumar, Palanisamy Mahesh ; Subramaniam, Jayapal ; Dinesh, Devakumar ; Chandramohan, Balamurugan
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3Biomedical and Life Sciences
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5Control
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7Dengue - transmission
8Dicotyledons
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10Humans
11Immunology
12Insect Vectors - drug effects
13Insecticides - chemical synthesis
14Insecticides - toxicity
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16Larva - growth & development
17Medical Microbiology
18Metal Nanoparticles - chemistry
19Metal Nanoparticles - toxicity
20Methods
21Microbiology
22Mosquito Control
23Nanoparticles
24Original Paper
25Phyllanthus - chemistry
26Plant Extracts - chemistry
27Plant Extracts - toxicity
28Plant Leaves - chemistry
29Production processes
30Silver
31Silver - chemistry
32Silver - toxicity
33Surface Plasmon Resonance
34Vector control
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atitleTackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae)
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abstractMosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. Aedes aegypti (Diptera: Culicidae) is the primary vector of dengue. The use of synthetic insecticides to control Aedes mosquitoes lead to high operational costs and adverse nontarget effects. In this scenario, eco-friendly control tools are a priority. We proposed a novel method to synthesize silver nanoparticles using the aqueous leaf extract of Phyllanthus niruri , a cheap and nontoxic material. The UV–vis spectrum of the aqueous medium containing silver nanostructures showed a peak at 420 nm corresponding to the surface plasmon resonance band of nanoparticles. SEM analyses of the synthesized nanoparticles showed a mean size of 30–60 nm. EDX spectrum showed the chemical composition of the synthesized nanoparticles. XRD highlighted that the nanoparticles are crystalline in nature with face-centered cubic geometry. Fourier transform infrared spectroscopy (FTIR) of nanoparticles exhibited prominent peaks 3,327.63, 2,125.87, 1,637.89, 644.35, 597.41, and 554.63 cm −1 . In laboratory assays, the aqueous extract of P. niruri was toxic against larval instars (I–IV) and pupae of A. aegypti . LC 50 was 158.24 ppm (I), 183.20 ppm (II), 210.53 ppm (III), 210.53 ppm (IV), and 358.08 ppm (pupae). P. niruri -synthesized nanoparticles were highly effective against A. aegypti , with LC 50 of 3.90 ppm (I), 5.01 ppm (II), 6.2 ppm (III), 8.9 ppm (IV), and 13.04 ppm (pupae). In the field, the application of silver nanoparticles (10 × LC 50 ) lead to A. aegypti larval reduction of 47.6 %, 76.7 % and 100 %, after 24, 48, and 72 h, while the P. niruri extract lead to 39.9 %, 69.2 % and 100 % of reduction, respectively. In adulticidal experiments, P. niruri extract and nanoparticles showed LC 50 and LC 90 of 174.14 and 6.68 ppm and 422.29 and 23.58 ppm, respectively. Overall, this study highlights that the possibility to employ P. niruri leaf extract and green-synthesized silver nanoparticles in mosquito control programs is concrete, since both are effective at lower doses if compared to synthetic products currently marketed, thus they could be an advantageous alternative to build newer and safer tools against dengue vectors.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid25669140
doi10.1007/s00436-015-4339-9