Arginine intake is associated with oxidative stress in a general population

Abstract Objective The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population-based study in Brazil (N = 549 adults)... Full description

Abstract Objective The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population-based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders. Results MDA levels were associated with meat intake ( P for linear trend = 0.031), protein from meat ( P for linear trend = 0.006), and arginine from meat ( P for linear trend = 0.044) after adjustments for confounders: age, sex, body mass index, smoking, physical activity, intake of fruit and vegetables, energy and heterocyclic amines, C-reactive protein levels, and polymorphisms in GSTM1 (glutathione S-transferase Mu 1) and GSTT1 (glutathione S-transferase theta 1) genes. Results were not significant for total protein and protein from vegetable intake ( P  > 0.05). Conclusions High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age-related diseases.